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HLA-B Produkte

(Major Histocompatibility Complex, Class I, B (HLA-B))

Kategorien

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte HLA-B Kategorien

HLA-B Antikörper

High quality antibodies with extensive validation data.

HLA-B ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-B Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene HLA-B Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, FACS, ICC, IHC, WB
Validierungen
  • (7)
Kat. Nr. ABIN5542339
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC, WB
Validierungen
  • (4)
Kat. Nr. ABIN7256404
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC, WB
Validierungen
  • (3)
Kat. Nr. ABIN7155621
Menge 100 μg
Datenblatt Datenblatt

Empfohlene HLA-B ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6957622
Menge 96 tests
Datenblatt Datenblatt

Empfohlene HLA-B Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Wheat germ
Validierungen
  • (1)
Kat. Nr. ABIN6386493
Menge 2 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN5712958
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
Kat. Nr. ABIN7123829
Menge 50 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren HLA-B Produkten

Lorente, Infantes, Abia, Barnea, Beer, García, Lasala, Jiménez, Mir, Morreale, Admon, López et al.: "A viral, transporter associated with antigen processing (TAP)-independent, high affinity ligand with alternative interactions endogenously presented by the nonclassical human leukocyte antigen E ..." in: The Journal of biological chemistry, Vol. 287, Issue 42, pp. 34895-903, (2012) (PubMed).

Lorente, García, López: "Allele-dependent processing pathways generate the endogenous human leukocyte antigen (HLA) class I peptide repertoire in transporters associated with antigen processing (TAP)-deficient cells." in: The Journal of biological chemistry, Vol. 286, Issue 44, pp. 38054-9, (2011) (PubMed).

Lorente, Infantes, Barnea, Beer, García, Lasala, Jiménez, Vilches, Lemonnier, Admon, López: "Multiple viral ligands naturally presented by different class I molecules in transporter antigen processing-deficient vaccinia virus-infected cells." in: Journal of virology, Vol. 86, Issue 1, pp. 527-41, (2011) (PubMed).

Lin, Tokunaga, Tanaka, Nakajima, Imanishi, Kashiwase, Bannai, Mizuno, Akaza, Tadokoro, Shibata, Juji: "Further molecular diversity in the HLA-B15 group." in: Tissue antigens, Vol. 47, Issue 4, pp. 265-74, (1996) (PubMed).

Hildebrand, Domena, Shen, Lau, Terasaki, Bunce, Marsh, Guttridge, Bias, Parham: "HLA-B15: a widespread and diverse family of HLA-B alleles." in: Tissue antigens, Vol. 43, Issue 4, pp. 209-18, (1994) (PubMed).

Little, Parham: "The HLA-Bw75 subtype of B15: molecular characterization and comparison with crossreacting antigens." in: Tissue antigens, Vol. 38, Issue 4, pp. 186-90, (1992) (PubMed).

Madrigal, Belich, Hildebrand, Benjamin, Little, Zemmour, Ennis, Ward, Petzl-Erler, du Toit: "Distinctive HLA-A,B antigens of black populations formed by interallelic conversion." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 149, Issue 10, pp. 3411-5, (1992) (PubMed).

Watkins, McAdam, Liu, Strang, Milford, Levine, Garber, Dogon, Lord, Ghim: "New recombinant HLA-B alleles in a tribe of South American Amerindians indicate rapid evolution of MHC class I loci." in: Nature, Vol. 357, Issue 6376, pp. 329-33, (1992) (PubMed).

Synonyme und alternative Namen zu HLA-B

major histocompatibility complex, class I, B (HLA-B), major histocompatibility complex, class I, B (BOLA-B), major histocompatibility complex, class I, B (MAMU-B18), major histocompatibility complex, class I, B (DKFZP469N1225), major histocompatibility complex nonclassical class Ib L homeolog (mhc1b.L), AS, HLAB, mhc1b, SPDA1

Bezeichner auf Proteinebene für HLA-B

  • HLA class I histocompatibility antigen, B alpha chain
  • MHC Class I HLA heavy chain
  • MHC HLA-B cell surface glycoprotein
  • MHC HLA-B transmembrane glycoprotein
  • MHC class I antigen GN00104
  • MHC class I antigen HLA-B heavy chain
  • MHC class I antigen SHCHA
  • leukocyte antigen class I-B
  • lymphocyte antigen
  • major histocompatibility complex, class I, B
  • major histocompatibility complex nonclassical class Ib L homeolog
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