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HLA-C Produkte

(Major Histocompatibility Complex Class I C (HLA-C))

Kategorien

HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles have been described [provided by RefSeq, Jul 2008].

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Ausgewählte HLA-C Kategorien

HLA-C Antikörper

High quality antibodies with extensive validation data.

HLA-C ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-C Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene HLA-C Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC, WB
Validierungen
  • (5)
Kat. Nr. ABIN7155625
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation ICC, IHC (p), WB
Validierungen
  • (5)
Kat. Nr. ABIN3043843
Menge 100 μg
Datenblatt Datenblatt
Reaktivität Human
Applikation ELISA, IF, IHC, WB
Validierungen
  • (4)
Kat. Nr. ABIN7155571
Menge 100 μg
Datenblatt Datenblatt

Empfohlene HLA-C ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6968422
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6962562
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN1571212
Menge 96 tests
Datenblatt Datenblatt

Empfohlene HLA-C Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3087850
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3087860
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3087849
Menge 0.5 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren HLA-C Produkten

Huang, Malu, McKenzie, Andrews, Talukder, Tieu, Karpinets, Haymaker, Forget, Williams, Wang, Mbofung, Wang, Davis, Lo, Wargo, Davies, Bernatchez, Heffernan, Amaria, Korkut, Peng, Roszik, Lizée et al.: "The RNA-binding Protein MEX3B Mediates Resistance to Cancer Immunotherapy by Downregulating HLA-A Expression. ..." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 24, Issue 14, pp. 3366-3376, (2018) (PubMed).

Apps, Qi, Carlson, Chen, Gao, Thomas, Yuki, Del Prete, Goulder, Brumme, Brumme, John, Mallal, Nelson, Bosch, Heckerman, Stein, Soderberg, Moody, Denny, Zeng, Fang, Moffett, Lifson, Goedert et al.: "Influence of HLA-C expression level on HIV control. ..." in: Science (New York, N.Y.), Vol. 340, Issue 6128, pp. 87-91, (2013) (PubMed).

Corrah, Goonetilleke, Kopycinski, Deeks, Cohen, Borrow, McMichael, Brackenridge: "Reappraisal of the relationship between the HIV-1-protective single-nucleotide polymorphism 35 kilobases upstream of the HLA-C gene and surface HLA-C expression." in: Journal of virology, Vol. 85, Issue 7, pp. 3367-74, (2011) (PubMed).

Braud, Allan, Wilson, McMichael: "TAP- and tapasin-dependent HLA-E surface expression correlates with the binding of an MHC class I leader peptide." in: Current biology : CB, Vol. 8, Issue 1, pp. 1-10, (1998) (PubMed).

Synonyme und alternative Namen zu HLA-C

major histocompatibility complex, class I, C (HLA-C), D6S204, HLA-JY3, HLC-C, PSORS1

Bezeichner auf Proteinebene für HLA-C

  • HLA class I histocompatibility antigen, C alpha chain
  • HLA class I histocompatibility antigen, Cw-1 alpha chain
  • MHC class I antigen heavy chain HLA-C
  • human leukocyte antigen-C alpha chain
  • major histocompatibility antigen HLA-C
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