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HLA B7 Produkte

(HLA Class I B7 Alpha (HLA B7))

Kategorien

HLA-B belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exon 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-B alleles have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte HLA B7 Kategorien

HLA B7 Antikörper

High quality antibodies with extensive validation data.

Empfohlene HLA B7 Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Non-Human Primate
Applikation FACS
Validierungen
  • (6)
  • (1)
Kat. Nr. ABIN1111104
Menge 100 tests
Datenblatt Datenblatt
Reaktivität Human, Non-Human Primate
Applikation FACS
Validierungen
  • (5)
Kat. Nr. ABIN1027673
Menge 0.1 mg
Datenblatt Datenblatt
Reaktivität Cynomolgus, Human
Applikation FACS
Validierungen
  • (1)
Kat. Nr. ABIN305300
Menge 0.1 mg
Datenblatt Datenblatt

Empfohlene HLA B7 Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source HEK-293 Cells
Validierungen
  • (1)
Kat. Nr. ABIN2722838
Menge 20 μg
Datenblatt Datenblatt

Neueste Publikationen zu unseren HLA B7 Produkten

Anania, Coscoy: "Palmitoylation of MIR2 is required for its function." in: Journal of virology, Vol. 85, Issue 5, pp. 2288-95, (2011) (PubMed).

Cortez-Gonzalez, Sidney, Adotevi, Sette, Millard, Lemonnier, Langlade-Demoyen, Zanetti: "Immunogenic HLA-B7-restricted peptides of hTRT." in: International immunology, Vol. 18, Issue 12, pp. 1707-18, (2006) (PubMed).

Hofmann, Glückmann, Kausche, Schmidt, Corvey, Lichtenfels, Huber, Albrecht, Karas, Herr: "Rapid and sensitive identification of major histocompatibility complex class I-associated tumor peptides by Nano-LC MALDI MS/MS." in: Molecular & cellular proteomics : MCP, Vol. 4, Issue 12, pp. 1888-97, (2005) (PubMed).

de la Salle, Saulquin, Mansour, Klayme, Fricker, Zimmer, Cazenave, Hanau, Bonneville, Houssaint, Lefranc, Naman: "Asymptomatic deficiency in the peptide transporter associated to antigen processing (TAP)." in: Clinical and experimental immunology, Vol. 128, Issue 3, pp. 525-31, (2002) (PubMed).

Yoshino, Ami, Terao, Tashiro, Honda: "Upgrading of flow cytometric analysis for absolute counts, cytokines and other antigenic molecules of cynomolgus monkeys (Macaca fascicularis) by using anti-human cross-reactive antibodies." in: Experimental animals / Japanese Association for Laboratory Animal Science, Vol. 49, Issue 2, pp. 97-110, (2000) (PubMed).

Rini, Selk, Vogelzang: "Phase I study of direct intralesional gene transfer of HLA-B7 into metastatic renal carcinoma lesions." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 10, pp. 2766-72, (1999) (PubMed).

Trapani, Vaughan, Tait, McKenzie: "Immunoradiometric assay for the rapid detection of HLA-B27." in: Immunology and cell biology, Vol. 66 ( Pt 3), pp. 215-9, (1991) (PubMed).

Storkus, Alexander, Payne, Dawson, Cresswell: "Reversal of natural killing susceptibility in target cells expressing transfected class I HLA genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 7, pp. 2361-4, (1989) (PubMed).

Synonyme und alternative Namen zu HLA B7

major histocompatibility complex, class I, B (HLA-B), AS, HLAB, SPDA1

Bezeichner auf Proteinebene für HLA B7

  • HLA class I histocompatibility antigen, B alpha chain
  • MHC Class I HLA heavy chain
  • MHC HLA-B cell surface glycoprotein
  • MHC HLA-B transmembrane glycoprotein
  • MHC class I antigen GN00104
  • MHC class I antigen HLA-B heavy chain
  • MHC class I antigen SHCHA
  • leukocyte antigen class I-B
  • lymphocyte antigen
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