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HLA-A Produkte

(Major Histocompatibility Complex, Class I, A (HLA-A))

Kategorien

HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles have been described. [provided by RefSeq, Jul 2008].

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Ausgewählte HLA-A Kategorien

HLA-A Antikörper

High quality antibodies with extensive validation data.

HLA-A ELISA Kits

Reliable ELISA kits for a wide range of species.

HLA-A Proteine

Proteins for various applications incl. WB, ELISA, IF etc.

Empfohlene HLA-A Antikörper

Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IF, IHC, WB
Validierungen
  • (7)
Kat. Nr. ABIN1873024
Menge 100 μL
Datenblatt Datenblatt
Reaktivität Human, Mouse, Rat
Applikation IHC, WB
Validierungen
  • (4)
Kat. Nr. ABIN7260257
Menge 200 μL
Datenblatt Datenblatt
Reaktivität Human
Applikation IF, IP, WB
Validierungen
  • (4)
Kat. Nr. ABIN516463
Menge 100 μL
Datenblatt Datenblatt

Empfohlene HLA-A ELISA Kits

Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6968423
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6962365
Menge 96 tests
Datenblatt Datenblatt
Reaktivität Human
Analytical Method Quantitative Sandwich ELISA
Validierungen
  • (1)
Kat. Nr. ABIN6957621
Menge 96 tests
Datenblatt Datenblatt

Empfohlene HLA-A Proteine

Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3073379
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Escherichia coli (E. coli)
Validierungen
  • (1)
Kat. Nr. ABIN3073375
Menge 1 mg
Datenblatt Datenblatt
Reaktivität Human
Source Insect Cells
Validierungen
  • (1)
Kat. Nr. ABIN3073374
Menge 0.5 mg
Datenblatt Datenblatt

Neueste Publikationen zu unseren HLA-A Produkten

Li, Xu, Zhao, Yu, Ge, Xu: "Comparison of the biological characteristics of human mesenchymal stem cells derived from exfoliated deciduous teeth, bone marrow, gingival tissue, and umbilical cord." in: Molecular medicine reports, Vol. 18, Issue 6, pp. 4969-4977, (2019) (PubMed).

Lawson, Ebetino, Mazur, Chantry, Paton-Hough, Evans, Lath, Tsoumpra, Lundy, Dobson, Quijano, Kwaasi, Dunford, Duan, Triffitt, Jeans, Russell: "The Pharmacological Profile of a Novel Highly Potent Bisphosphonate, OX14 (1-Fluoro-2-(Imidazo-[1,2-α]Pyridin-3-yl)-Ethyl-Bisphosphonate)." in: Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research, Vol. 32, Issue 9, pp. 1860-1869, (2018) (PubMed).

Charpak-Amikam, Kubsch, Seidel, Oiknine-Djian, Cavaletto, Yamin, Schmiedel, Wolf, Gribaudo, Messerle, Cicin-Sain, Mandelboim: "Human cytomegalovirus escapes immune recognition by NK cells through the downregulation of B7-H6 by the viral genes US18 and US20." in: Scientific reports, Vol. 7, Issue 1, pp. 8661, (2017) (PubMed).

Loubaki, Chabot, Bazin: "Involvement of the TNF-α/TGF-β/IDO axis in IVIg-induced immune tolerance." in: Cytokine, Vol. 71, Issue 2, pp. 181-7, (2015) (PubMed).

Klöß, Chambron, Gardlowski, Arseniev, Koch, Esser, Glienke, Seitz, Köhl: "Increased sMICA and TGFβ1 levels in HNSCC patients impair NKG2D-dependent functionality of activated NK cells." in: Oncoimmunology, Vol. 4, Issue 11, pp. e1055993, (2015) (PubMed).

Dupuy, Lambert, Zucman, Choukem, Tognarelli, Pages, Lebbé, Caillat-Zucman: "Human Herpesvirus 8 (HHV8) sequentially shapes the NK cell repertoire during the course of asymptomatic infection and Kaposi sarcoma." in: PLoS pathogens, Vol. 8, Issue 1, pp. e1002486, (2012) (PubMed).

Parham, Barnstable, Bodmer: "Use of a monoclonal antibody (W6/32) in structural studies of HLA-A,B,C, antigens." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 123, Issue 1, pp. 342-9, (1979) (PubMed).

Synonyme und alternative Namen zu HLA-A

major histocompatibility complex, class I, A (HLA-A), HLAA

Bezeichner auf Proteinebene für HLA-A

  • HLA class I histocompatibility antigen, A-1 alpha chain
  • MHC class I antigen HLA-A heavy chain
  • antigen presenting molecule
  • leukocyte antigen class I-A
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