NR2F6 Antikörper (N-Term)

Produktnummer ABIN1539216

Produktdetails anti-NR2F6 Antikörper

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Bindungsspezifität: AA 25-53, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2F6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NR2F6 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 25-53 amino acids from the N-terminal region of human NR2F6.

Klon: RB36666

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: NR2F6 Antibody (N-term) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu NR2F6

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Andere Bezeichnung: NR2F6 (NR2F6 Produkte)

Synonyme: EAR-2 antikoerper, EAR2 antikoerper, ERBAL2 antikoerper, AV090102 antikoerper, COUP-TF3 antikoerper, Erbal2 antikoerper, COUP(II) antikoerper, NR2F6 antikoerper, couptf2 antikoerper, fc94g11 antikoerper, wu:fc94g11 antikoerper, zgc:77259 antikoerper, ear-2 antikoerper, ear2 antikoerper, erbal2 antikoerper, nr2f6l antikoerper, wu:fc72d04 antikoerper, zgc:77260 antikoerper, nuclear receptor subfamily 2 group F member 6 antikoerper, nuclear receptor subfamily 2, group F, member 6 antikoerper, nuclear receptor subfamily 2, group F, member 6a antikoerper, nuclear receptor subfamily 2 group F member 6 L homeolog antikoerper, nuclear receptor subfamily 2, group F, member 6b antikoerper, NR2F6 antikoerper, Nr2f6 antikoerper, nr2f6a antikoerper, nr2f6.L antikoerper, nr2f6 antikoerper, nr2f6b antikoerper

Hintergrund: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4(+) T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock, is required early in the development of the locus coeruleus (LC).

Molekulargewicht: 42979

Gen-ID: 2063

NCBI Accession: NP_005225

UniProt: P10588

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism