NR2F6 Antikörper (N-Term)

Produktnummer ABIN7184487

Produktdetails anti-NR2F6 Antikörper

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Bindungsspezifität: N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2F6 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from N-terminal of Human NR2F6.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB:1:500-1:3000, IHC:1:50-1:100, IF:1:100-1:500,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu NR2F6

Target: NR2F6 (Nuclear Receptor Subfamily 2, Group F, Member 6 (NR2F6))

Andere Bezeichnung: NR2F6 (NR2F6 Produkte)

Synonyme: EAR-2 antikoerper, EAR2 antikoerper, ERBAL2 antikoerper, AV090102 antikoerper, COUP-TF3 antikoerper, Erbal2 antikoerper, COUP(II) antikoerper, NR2F6 antikoerper, couptf2 antikoerper, fc94g11 antikoerper, wu:fc94g11 antikoerper, zgc:77259 antikoerper, ear-2 antikoerper, ear2 antikoerper, erbal2 antikoerper, nr2f6l antikoerper, wu:fc72d04 antikoerper, zgc:77260 antikoerper, nuclear receptor subfamily 2 group F member 6 antikoerper, nuclear receptor subfamily 2, group F, member 6 antikoerper, nuclear receptor subfamily 2, group F, member 6a antikoerper, nuclear receptor subfamily 2 group F member 6 L homeolog antikoerper, nuclear receptor subfamily 2, group F, member 6b antikoerper, NR2F6 antikoerper, Nr2f6 antikoerper, nr2f6a antikoerper, nr2f6.L antikoerper, nr2f6 antikoerper, nr2f6b antikoerper

Hintergrund:

Background: Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock, is required early in the development of the locus coeruleus (LC).

Miyajima N., Nucleic Acids Res. 16:11057-11074(1988).
The MGC Project Team, Genome Res. 14:2121-2127(2004).
Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

Aliases: EAR 2 antibody, EAR-2 antibody, EAR2 antibody, ERBA RELATED 2 antibody, ERBA related gene 2 antibody, ERBAL2 antibody, Nr2f6 antibody, NR2F6_HUMAN antibody, Nuclear receptor subfamily 2 group F member 6 antibody, Orphan nuclear receptor EAR2 (V erbA related protein EAR 2) antibody, v erb a avian erythroblastic leukemia viral oncogene homolog like antibody, V erbA related protein EAR 2 antibody, V-erbA-related protein 2 antibody

UniProt: P10588

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Photoperiodism