CDKN2A Antikörper (AA 39-65)

Produktnummer ABIN1538376

Produktdetails anti-CDKN2A Antikörper

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Bindungsspezifität: AA 39-65

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CDKN2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Cdkn2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 39-65 amino acids from the Central region of mouse Cdkn2a.

Klon: RB40175

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Mouse Cdkn2a Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, keep at -20 °C.

Haltbarkeit: 6 months

Details zu CDKN2A

Target: CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))

Andere Bezeichnung: Cdkn2a (CDKN2A Produkte)

Synonyme: Arf antikoerper, p16 antikoerper, MTS1 antikoerper, INK4A antikoerper, p19ARF antikoerper, p16Cdkn2a antikoerper, ARF antikoerper, CDK4I antikoerper, CDKN2 antikoerper, CMM2 antikoerper, INK4 antikoerper, MLM antikoerper, MTS-1 antikoerper, P14 antikoerper, P14ARF antikoerper, P16 antikoerper, P16-INK4A antikoerper, P16INK4 antikoerper, P16INK4A antikoerper, P19 antikoerper, P19ARF antikoerper, TP16 antikoerper, ARF-INK4a antikoerper, INK4a-ARF antikoerper, Ink4a/Arf antikoerper, Pctr1 antikoerper, p16(INK4a) antikoerper, p16INK4a antikoerper, p19 antikoerper, cyclin-dependent kinase inhibitor 2A antikoerper, cyclin dependent kinase inhibitor 2A antikoerper, Cdkn2a antikoerper, LOC100731972 antikoerper, LOC100340625 antikoerper, CDKN2A antikoerper

Hintergrund: Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development.

Molekulargewicht: 19238

Gen-ID: 12578

NCBI Accession: NP_034007

UniProt: Q64364

Pathways: Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagie, Positive Regulation of Response to DNA Damage Stimulus