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CDKN2A Antikörper (C-Term)

CDKN2A Reaktivität: Human WB, IF, FACS, IHC (p) Wirt: Kaninchen Polyclonal RB19093 unconjugated
Produktnummer ABIN1981278
  • Target Alle CDKN2A Antikörper anzeigen
    CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
    Bindungsspezifität
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 104-131, C-Term
    Reaktivität
    • 29
    • 4
    • 2
    Human
    Wirt
    • 30
    • 3
    Kaninchen
    Klonalität
    • 28
    • 5
    Polyklonal
    Konjugat
    • 30
    • 1
    • 1
    • 1
    Dieser CDKN2A Antikörper ist unkonjugiert
    Applikation
    • 23
    • 14
    • 9
    • 6
    • 5
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is purified through a protein A column, followed by peptide affinity purification.
    Immunogen
    This p16INK4a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-131 amino acids from the C-terminal region of human p16INK4a.
    Klon
    RB19093
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product CDKN2A Primärantikörper
  • Applikationshinweise
    IF: 1:10~50. WB: 1:2000. WB: 1:2000. IHC-P-Leica: 1:500. FC: 1:25
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
    Haltbarkeit
    6 months
  • Han, Li, Zhang, Qin, Yang, Wang, Yuan, Xia: "Brain lipid-binding protein promotes proliferation and modulates cell cycle in C6 rat glioma cells." in: International journal of oncology, Vol. 51, Issue 5, pp. 1439-1448, (2018) (PubMed).

  • Target
    CDKN2A (Cyclin-Dependent Kinase Inhibitor 2A (Melanoma, P16, Inhibits CDK4) (CDKN2A))
    Andere Bezeichnung
    p16INK4a (CDKN2A Produkte)
    Synonyme
    Arf antikoerper, p16 antikoerper, MTS1 antikoerper, INK4A antikoerper, p19ARF antikoerper, p16Cdkn2a antikoerper, ARF antikoerper, CDK4I antikoerper, CDKN2 antikoerper, CMM2 antikoerper, INK4 antikoerper, MLM antikoerper, MTS-1 antikoerper, P14 antikoerper, P14ARF antikoerper, P16 antikoerper, P16-INK4A antikoerper, P16INK4 antikoerper, P16INK4A antikoerper, P19 antikoerper, P19ARF antikoerper, TP16 antikoerper, ARF-INK4a antikoerper, INK4a-ARF antikoerper, Ink4a/Arf antikoerper, Pctr1 antikoerper, p16(INK4a) antikoerper, p16INK4a antikoerper, p19 antikoerper, cyclin-dependent kinase inhibitor 2A antikoerper, cyclin dependent kinase inhibitor 2A antikoerper, Cdkn2a antikoerper, LOC100731972 antikoerper, LOC100340625 antikoerper, CDKN2A antikoerper
    Hintergrund
    This gene generates several transcript variants which differ in their first exons. At least three alternatively spliced variants encoding distinct proteins have been reported, two of which encode structurally related isoforms known to function as inhibitors of CDK4 kinase. The remaining transcript includes an alternate first exon located 20 Kb upstream of the remainder of the gene, this transcript contains an alternate open reading frame (ARF) that specifies a protein which is structurally unrelated to the products of the other variants. This ARF product functions as a stabilizer of the tumor suppressor protein p53 as it can interact with, and sequester, MDM1, a protein responsible for the degradation of p53. In spite of the structural and functional differences, the CDK inhibitor isoforms and the ARF product encoded by this gene, through the regulatory roles of CDK4 and p53 in cell cycle G1 progression, share a common functionality in cell cycle G1 control. This gene is frequently mutated or deleted in a wide variety of tumors, and is known to be an important tumor suppressor gene.
    Molekulargewicht
    16533
    Gen-ID
    1029
    NCBI Accession
    NP_000068, NP_001182061, NP_478104
    UniProt
    P42771
    Pathways
    Mitotic G1-G1/S Phases, Stem Cell Maintenance, Positive Regulation of Endopeptidase Activity, Autophagie, Positive Regulation of Response to DNA Damage Stimulus
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