CEP290 Antikörper (Internal Region)

Produktnummer ABIN1449753

Produktdetails anti-CEP290 Antikörper

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser CEP290 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (IF)

Sequenz: C-RNSKHLKQQQ YRAEN

Aufreinigung: Ammonium Sulphate Precipitation followed by Antigen Affinity Chromatography using the immunizing peptide

Immunogen: Peptide with sequence from the internal region of the protein sequence according to NP_079390.3. Genename: CEP290

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3, 0.02 % Sodium Azide, 0.5 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Andere Bezeichnung: CEP290 (CEP290 Produkte)

Synonyme: ct87 antikoerper, mks4 antikoerper, rd16 antikoerper, bbs14 antikoerper, jbts5 antikoerper, jbts6 antikoerper, lca10 antikoerper, nphp6 antikoerper, slsn6 antikoerper, sh11ag antikoerper, MGC81471 antikoerper, 3h11ag antikoerper, RGD1311640 antikoerper, BC004690 antikoerper, Nphp6 antikoerper, b2b1454Clo antikoerper, b2b1752Clo antikoerper, im:7145703 antikoerper, im:7147820 antikoerper, 3H11Ag antikoerper, BBS14 antikoerper, CT87 antikoerper, JBTS5 antikoerper, LCA10 antikoerper, MKS4 antikoerper, NPHP6 antikoerper, POC3 antikoerper, SLSN6 antikoerper, centrosomal protein 290 antikoerper, centrosomal protein 290 L homeolog antikoerper, centrosomal protein 290kDa antikoerper, CEP290 antikoerper, cep290.L antikoerper, cep290 antikoerper, Cep290 antikoerper

Hintergrund: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2

Gen-ID: 80184

NCBI Accession: NP_079390

Pathways: cAMP Metabolic Process, M Phase