GCLM Antikörper (N-Term)

Produktnummer ABIN1449395

Produktdetails anti-GCLM Antikörper

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Bindungsspezifität: AA 1-274, N-Term

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GCLM Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein-G affinity chromatography

Immunogen: Recombinant human GCLM (1-274aa) purified from E. coli

Klon: AT2D12

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Phosphate -Buffered Saline ( pH 7.4) with 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GCLM

Target: GCLM (Glutamate-Cysteine Ligase, Modifier Subunit (GCLM))

Andere Bezeichnung: GCLM / GLCLR (GCLM Produkte)

Synonyme: Glclr antikoerper, GLCLR antikoerper, id:ibd3182 antikoerper, wu:fi24c07 antikoerper, zgc:55903 antikoerper, AI649393 antikoerper, Gcmc antikoerper, glutamate-cysteine ligase regulatory subunit antikoerper, glutamate cysteine ligase, modifier subunit antikoerper, glutamate-cysteine ligase modifier subunit antikoerper, glutamate-cysteine ligase, modifier subunit antikoerper, glutamate-cysteine ligase, modifier subunit L homeolog antikoerper, PTRG_09814 antikoerper, Gclm antikoerper, GCLM antikoerper, gclm antikoerper, gclm.L antikoerper

Hintergrund: GCLM (Glutamate-cysteine ligase, modifier subunit), also known as gamma-glutamylcysteine synthetase, is first rate limiting enzyme of glutathione synthesis. GCLM is heterodimer of a heavy catalytic subunit and a light regulatory subunit that is responsive to inflammation, phenolic antioxidants, heat shock, oxidants and cytokines. GCLM deficiency has been implicated in some forms of hemolytic anemia. Also, GCLM is a molecular target for amelioration of cisplatin restance in lung cancer.Synonyms: GCS light chain, Gamma-ECS regulatory subunit, Gamma-glutamylcysteine synthetase regulatory subunit, Glutamate-cysteine ligase modifier subunit, Glutamate-cysteine ligase regulatory subunit

Gen-ID: 2730

NCBI Accession: NP_002052

UniProt: P48507