NR2E1 Antikörper (AA 351-385) (Cy5.5)

Produktnummer ABIN1407773

Produktdetails anti-NR2E1 Antikörper (Cy5.5)

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Bindungsspezifität: AA 351-385

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR2E1 Antikörper ist konjugiert mit Cy5.5

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Homologie: Human,Mouse,Rat,Dog,Cow,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NR2E1/Tailless

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu NR2E1

Target: NR2E1 (Nuclear Receptor Subfamily 2, Group E, Member 1 (NR2E1))

Andere Bezeichnung: NR2E1/Tailless (NR2E1 Produkte)

Synonyme: NR2E1 antikoerper, TLL antikoerper, TLX antikoerper, XTLL antikoerper, Mtl1 antikoerper, Mtll antikoerper, Tlx antikoerper, fierce antikoerper, frc antikoerper, tailless antikoerper, fc30e03 antikoerper, fc39f12 antikoerper, wu:fc30e03 antikoerper, wu:fc39f12 antikoerper, zgc:100991 antikoerper, Xtll antikoerper, nr2e1-A antikoerper, tlx antikoerper, nuclear receptor subfamily 2 group E member 1 antikoerper, nuclear receptor subfamily 2, group E, member 1 antikoerper, nuclear receptor subfamily 2 group E member 1 S homeolog antikoerper, NR2E1 antikoerper, Nr2e1 antikoerper, nr2e1 antikoerper, nr2e1.S antikoerper

Hintergrund:

Synonyms: hTll, nr2e1, NR2E1_HUMAN, Nuclear receptor subfamily 2 group E member 1, Nuclear receptor TLX, Orphan nuclear receptor NR2E1, Protein tailless homolog, Tailless homolog, Tll, TLX, XTLL.

Background: NR2 proteins are a large family of nuclear hormone receptor transcription factors. The proteins belonging to this family are characterized by discrete domains functioning in DNA and ligand binding. NR2E1 (nuclear receptor subfamily 2, group E, member 1), also known as TLX, is an essential component in the formation of synaptic plasticity and dendritic structure in retinal astrocytes. In addition, NR2E1 is a orphan receptor that binds DNA as part of the hormone response element (HRE), a transcription regulator for hormones. DNA-binding orphan receptors have the conserved sequence 5'-AAGGTCA-3', a motif that determines substrate binding specificity. NR2E1 is expressed in brain tissue, with highest levels in astrocytes, and is localized to the nucleus. Mutations in the gene that encodes NR2E1 may lead to retinal dystrophy, a disorder characterized by a reduction in the thickness of the retina.

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance