LIG4 Antikörper (AA 51-150) (Alexa Fluor 647)

Produktnummer ABIN1396061

Produktdetails anti-LIG4 Antikörper (Alexa Fluor 647)

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Bindungsspezifität: AA 51-150

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIG4 Antikörper ist konjugiert mit Alexa Fluor 647

Applikation: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Kreuzreaktivität: Human

Homologie: Mouse,Rat,Dog,Cow,Sheep,Horse,Chicken,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human DNA Ligase IV

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu LIG4

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Andere Bezeichnung: DNA Ligase IV/LIG4 (LIG4 Produkte)

Synonyme: zgc:165595 antikoerper, lig4 antikoerper, DNA LIGASE IV antikoerper, LIG4 antikoerper, lig4-A antikoerper, 5830471N16Rik antikoerper, tiny antikoerper, DNL4 antikoerper, ligase IV, DNA, ATP-dependent antikoerper, DNA ligase 4 antikoerper, ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining antikoerper, DNA ligase IV antikoerper, ligase IV, DNA, ATP-dependent L homeolog antikoerper, lig4 antikoerper, LIG4 antikoerper, LOC100212302 antikoerper, CpipJ_CPIJ005161 antikoerper, PTRG_09982 antikoerper, MCYG_05151 antikoerper, LOC657210 antikoerper, ATLIG4 antikoerper, lig4.L antikoerper, Lig4 antikoerper

Hintergrund:

Synonyms: LIG4S, DNA ligase 4, DNA ligase IV, Polydeoxyribonucleotide synthase [ATP] 4, LIG4

Background: Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends.

Gen-ID: 3981

UniProt: P49917

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response