LIG4 Antikörper

Produktnummer ABIN7246691

Produktdetails anti-LIG4 Antikörper

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LIG4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Produktmerkmale: Polyclonal Antibody

Aufreinigung: Antigen affinity purification

Immunogen: Fusion protein of human LIG4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:30-1:150, ELISA 1:5000-1:10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.72 mg/mL

Buffer: PBS with 0.05 % Sodium azide and 40 % Glycerol, pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Avoid freeze / thaw cycles.

Details zu LIG4

Target: LIG4 (Ligase IV, DNA, ATP-Dependent (LIG4))

Andere Bezeichnung: LIG4 (LIG4 Produkte)

Synonyme: zgc:165595 antikoerper, lig4 antikoerper, DNA LIGASE IV antikoerper, LIG4 antikoerper, lig4-A antikoerper, 5830471N16Rik antikoerper, tiny antikoerper, DNL4 antikoerper, ligase IV, DNA, ATP-dependent antikoerper, DNA ligase 4 antikoerper, ATP-dependent DNA ligase implicated in dsDNA break repair via nonhomologous end-joining antikoerper, DNA ligase IV antikoerper, ligase IV, DNA, ATP-dependent L homeolog antikoerper, lig4 antikoerper, LIG4 antikoerper, LOC100212302 antikoerper, CpipJ_CPIJ005161 antikoerper, PTRG_09982 antikoerper, MCYG_05151 antikoerper, LOC657210 antikoerper, ATLIG4 antikoerper, lig4.L antikoerper, Lig4 antikoerper

Hintergrund: The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal structure of the complex formed by this protein and XRCC4 has been resolved. Defects in this gene are the cause of LIG4 syndrome. Alternatively spliced transcript variants encoding the same protein have been observed.

UniProt: P49917

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response