RIC8A Antikörper (AA 301-400)

Produktnummer ABIN1386529

Produktdetails anti-RIC8A Antikörper

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Bindungsspezifität: AA 301-400

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RIC8A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)

Homologie: Human,Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human RIC8A

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu RIC8A

Target: RIC8A (Resistance To Inhibitors of Cholinesterase 8 Homolog A (C. Elegans) (RIC8A))

Andere Bezeichnung: RIC8A (RIC8A Produkte)

Synonyme: RIC8 antikoerper, AI114950 antikoerper, RIC-8 antikoerper, Ric8a antikoerper, Ric-8A antikoerper, Ric8 antikoerper, ric-8 antikoerper, ric8 antikoerper, synembryn antikoerper, xtric-8 antikoerper, zgc:92294 antikoerper, Syn antikoerper, ric8a antikoerper, ric8ab antikoerper, CG15797 antikoerper, DmRic8 antikoerper, Dmel\\CG15797 antikoerper, Ric-8 antikoerper, l(1)G0397 antikoerper, ric-8a antikoerper, ricc8aa antikoerper, fj97c10 antikoerper, synbl antikoerper, wu:fj97c10 antikoerper, RIC8 guanine nucleotide exchange factor A antikoerper, microRNA 6743 antikoerper, synembryn-A antikoerper, RIC8 guanine nucleotide exchange factor A L homeolog antikoerper, CG15797 gene product from transcript CG15797-RB antikoerper, synembryn antikoerper, RIC8 guanine nucleotide exchange factor A S homeolog antikoerper, Synembryn antikoerper, RIC8 guanine nucleotide exchange factor B antikoerper, RIC8A antikoerper, Ric8a antikoerper, ric8a antikoerper, MIR6743 antikoerper, Tsp_08768 antikoerper, ric8a.L antikoerper, LOC411841 antikoerper, ric8a.S antikoerper, ric-8 antikoerper, ric8b antikoerper

Hintergrund:

Synonyms: Protein Ric-8A, resistance to inhibitors of cholinesterase 8 homolog A C. elegans, RIC8, RIC8A, RIC8A_HUMAN, synembryn, Synembryn-A, MGC104517, MGC131931, MGC148073, MGC148074.

Background: The Ras superfamily of GTPases can be subdivided into the Ras, Rho/Rac, Sar, Rab, Arf, Rap and Ran subfamilies, all of which control multiple aspects of cell function, including cytoskeletal rearrangement, nuclear signaling and cell growth. The Ras superfamily of GTPases function as regulated switches that toggle between a biologically active GTP-bound and an inactive GDP-bound form. This activation is catalyzed by guanine nucleotide exchange factors (GEFs). RIC-8A (resistance to inhibitors of cholinesterase 8 homolog A), also known as RIC8 or Synembryn-A, is a 530 amino acid cytoplasmic protein that can activate several G-alpha proteins, including G?i-1, G?q and G?o. Functioning as a guanine nucleotide exchange factor, RIC-8A binds to GDP-associated substrates and exchanges bound GDP for free GTP. Via its ability to stimulate protein function, RIC-8A plays a role in regulating mitotic movement and may be involved in receptor-mediated ERK activation. RIC-8A is expressed as three isoforms due to alternative splicing events.

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling, Feeding Behaviour, Asymmetric Protein Localization