EPS15 Antikörper (AA 161-260)

Produktnummer ABIN1386477

Produktdetails anti-EPS15 Antikörper

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Bindungsspezifität: AA 161-260

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EPS15 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Homologie: Human,Mouse,Rat,Pig

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human EPS15

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu EPS15

Target: EPS15 (Epidermal Growth Factor Receptor Pathway Substrate 15 (EPS15))

Andere Bezeichnung: EPS15 (EPS15 Produkte)

Synonyme: AF-1P antikoerper, AF1P antikoerper, MLLT5 antikoerper, CG16932 antikoerper, Dmel\\CG16932 antikoerper, EH1 antikoerper, EPS-15 antikoerper, Eps15 antikoerper, anon-WO0118547.85 antikoerper, eps-15 antikoerper, eps15 antikoerper, i31 antikoerper, 2410112D09Rik antikoerper, RGD1307641 antikoerper, epidermal growth factor receptor pathway substrate 15 antikoerper, Epidermal growth factor receptor pathway substrate clone 15 antikoerper, hypothetical protein antikoerper, EPS15 antikoerper, Eps-15 antikoerper, eps15 antikoerper, Eps15 antikoerper, PGTG_06574 antikoerper

Hintergrund:

Synonyms: AF 1P, AF 1p protein, AF1P, ALL1 fused gene from chromosome 1, Epidermal growth factor receptor pathway substrate 15, Epidermal growth factor receptor substrate 15, EPS 15, MLLT 5, MLLT5, Protein Eps 15, Protein Eps15, EPS15_HUMAN.

Background: Elucidation of the mechanism by which receptor tyrosine kinases (RTKs) modulate cellular physiology in response to stimuli is critical to the understanding of growth regulation. Miscues in RTK signaling pathways can result in cellular transformation and ultimately in cancer. Two novel EGF receptor substrates designated EGF-receptor pathway substrates 8 and 15, or Eps8 and Eps15, have been described. Eps8 and Eps15 are proteins, respectively that become tyrosine phosphorylated subsequent to EGF stimulation. Overexpression of Eps15 in NIH/3T3 cells causes cellular transformation, implying involvement in the regulation of cell proliferation. Eps15 is capable of binding the amino terminal portion of Crk via a conserved proline-rich domain, characteristic of all Crk binding proteins (5). Overexpression of Eps8 in both fibroblasts and hematopoietic cells results in an increased mitogenic response to EGF. Eps8 has been shown to associate with the EGF receptor despite its lack of a functional SH2 domain. Further characterization suggests the protein has both a PH domain and a SH3 domain, the functional significance of which are not yet known.

Pathways: EGFR Signaling Pathway, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, EGFR Downregulation