IRF3 Antikörper (AA 394-398)
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- Target Alle IRF3 Antikörper anzeigen
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
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Bindungsspezifität
- AA 394-398
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser IRF3 Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB)
- Spezifität
- The antibody detects endogenous level of total IRF-3 protein.
- Immunogen
- Peptide sequence around AA 394-398 (H-I-S-N-S) derived from Human IRF-3.
- Top Product
- Discover our top product IRF3 Primärantikörper
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anti-Interferon Regulatory Factor 3 (IRF3) (pSer396) antibody
IRF3 Reaktivität: Human, Maus, Ratte, Affe WB, ELISA, IHC (p), IF (cc), IF (p), ICC, IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) antibodyIRF3 Reaktivität: Human, Maus, Ratte WB, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibodyIRF3 Reaktivität: Human WB, IHC, IF, ChIP Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibodyIRF3 Reaktivität: Human WB, ELISA, IF, IP Wirt: Maus Monoclonal 3C8 unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibodyIRF3 Reaktivität: Human WB, IHC, IP, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibodyIRF3 Reaktivität: Human, Maus, Ratte, Affe, Rind (Kuh) WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibodyIRF3 Reaktivität: Human, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1268-1341) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibodyIRF3 Reaktivität: Human WB, ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Western blotting: 1: 500-1: 1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Lagerung
- 4 °C/-20 °C
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- Target
- IRF3 (Interferon Regulatory Factor 3 (IRF3))
- Andere Bezeichnung
- IRF-3 (IRF3 Produkte)
- Synonyme
- irf3 antikoerper, IRF3 antikoerper, C920001K05Rik antikoerper, IRF-3 antikoerper, interferon regulatory factor 3 antikoerper, interferon regulatory factor 7 antikoerper, irf3 antikoerper, IRF3 antikoerper, irf-3 antikoerper, Irf3 antikoerper, IRF7 antikoerper
- Hintergrund
- Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters. Acts as a more potent activator of the IFN-beta (IFNB) gene than the IFN-alpha (IFNA) gene and plays a critical role in both the early and late phases of the IFNA/B gene induction. Found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein (CREBBP) to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes. Can activate distinct gene expression programs in macrophages and can induce significant apoptosis in primary macrophages.
- Molekulargewicht
- 45-55 kDa
- Pathways
- TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
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