NR5A1 Antikörper (Internal Region)

Produktnummer ABIN122633

Produktdetails anti-NR5A1 Antikörper

Target: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Bindungsspezifität: Internal Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NR5A1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: This antibody detects Steroidogenic factor 1. BLAST analysis of the peptide immunogen showed no homology with other human proteins, except TRIM23 (47 %).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Produktmerkmale: Synonyms: STF-1, SF-1, NR5A1, AD4BP, FTZF1, SF1, Nuclear receptor subfamily 5 group A member 1,Adrenal 4-binding protein, Steroid hormone receptor Ad4BP, Fushi tarazu factor homolog 1

Aufreinigung: Immunoaffinity chromatography

Immunogen: Synthetic peptide - KLH conjugatedEpitope: internal domain of humanGenename: NR5A1Remarks: The immunizing peptide shows 88 % identity (100 % similarity) with mouse and88 % identity (100 % similarity) with rat.

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry with formalin fixed paraffin embedded tissues: 2-18 μg/mLAntigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100C for 20 min. Remove fromheat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween(TBST) for 1 min. at room temperature.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 0.09 % Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu NR5A1

Target: NR5A1 (Nuclear Receptor Subfamily 5, Group A, Member 1 (NR5A1))

Andere Bezeichnung: Steroidogenic Factor 1 (NR5A1 Produkte)

Synonyme: AD4BP antikoerper, ELP antikoerper, FTZ1 antikoerper, FTZF1 antikoerper, POF7 antikoerper, SF-1 antikoerper, SF1 antikoerper, SPGF8 antikoerper, SRXY3 antikoerper, Ad4BP antikoerper, ELP-3 antikoerper, Ftz-F1 antikoerper, Ftzf1 antikoerper, Ad4BP/SF-1 antikoerper, Ad4bp antikoerper, Sf-1 antikoerper, NR5A1 antikoerper, sf-1 antikoerper, elp antikoerper, sf1 antikoerper, ftz1 antikoerper, ad4bp antikoerper, ftzf1 antikoerper, SF-1/Ad4BP antikoerper, SI:zC167P9.2 antikoerper, ff1d antikoerper, nr5a2l antikoerper, nuclear receptor subfamily 5 group A member 1 antikoerper, nuclear receptor subfamily 5, group A, member 1 antikoerper, nuclear receptor subfamily 5 group A member 1 L homeolog antikoerper, nuclear receptor subfamily 6 group A member 1 antikoerper, nuclear receptor subfamily 5, group A, member 1b antikoerper, NR5A1 antikoerper, Nr5a1 antikoerper, nr5a1.L antikoerper, nr5a1 antikoerper, NR6A1 antikoerper, nr5a1b antikoerper

Hintergrund: Steroidogenic factor 1 (SF-1), a NR5 Fushi Tarazu-Like Receptor, has been shown to affect sexual differentiation, steroid metabolism, and neural development. SF-1 binds as a monomer and regulates all steroidogenic p450 genes, Mullerian inhibiting substance, the gonadotrophins, the ACTH receptor, oxytocin, nuclear receptor DAX-1, and several other genes. Four alternatively spliced isoforms of SF-1 have been isolated in mice, and they differ at the N and C termini but are identical in the DNA-binding domain. SF-1 expression has been documented in human brain, adrenal, spleen, liver, heart, ovary, testis, and placenta. ESTs have been isolated from human tissue libraries, including cancerous adrenal and normal lung and testis.Synonyms: AD4BP, Adrenal 4-binding protein, FTZF1, Fushi tarazu factor homolog 1, NR5A1, Nuclear receptor subfamily 5 group A member 1, SF-1, SF1, STF-1, Steroid hormone receptor Ad4BP

Gen-ID: 2516

UniProt: Q13285

Pathways: Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Maintenance of Protein Location