SOCS4 Antikörper (C-Term)

Produktnummer ABIN1109094

Produktdetails anti-SOCS4 Antikörper

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Bindungsspezifität: C-Term

Reaktivität: Human, Rind (Kuh), Schwein

Wirt: Ziege

Klonalität: Polyklonal

Konjugat: Dieser SOCS4 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Sequenz: C-SKVRVLRIDA PEQQ

Spezifität: This antibody detects SOCS-4 at C-term.

Kreuzreaktivität (Details): Species reactivity (expected):Pig, Bovine.
Species reactivity (tested):Human.

Aufreinigung: Immunoaffinity Chromatography

Immunogen: Synthetic peptide with sequence from the C Terminus of Human SOCS4 (NP_543143.1, NP_955453.1). Genename: SOCS4

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.5 mg/mL

Buffer: Tris saline, pH ~7.3

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu SOCS4

Target: SOCS4 (Suppressor of Cytokine Signaling 4 (SOCS4))

Andere Bezeichnung: SOCS4 (SOCS4 Produkte)

Synonyme: SOCS7 antikoerper, socs4 antikoerper, SOCS4 antikoerper, 3110032M18Rik antikoerper, A730004F22Rik antikoerper, AI427843 antikoerper, AU015727 antikoerper, AU015859 antikoerper, Socs7 antikoerper, SOCS6 antikoerper, socs7 antikoerper, socs4a antikoerper, suppressor of cytokine signaling 4 antikoerper, SOCS4 antikoerper, socs4 antikoerper, Socs4 antikoerper

Hintergrund: Accumulating evidence has demonstrated that cytokine receptor signaling is negatively regulated by a family of Src homology 2 domain-containing adaptor molecules termed SOCS (Suppressor of Cytokine Signaling) (1-3). Currently, there are eight members of the SOCS family that have been recognized, SOCS-1, -2, -3, -4, - 5, -6, -7 and CIS. Structurally, the SOCS proteins are composed of an N-terminus region of variable length and amino acid composition, a central SH2 domain, and a previously unrecognized C-terminus motif that has been called the SOCS box (4). The SOCS proteins appear to form part of a classical negative feed back loop that regulates cytokine signal transduction via a STATinduced transcriptional mechanism (5). Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. Within the SOCS subfamily, SOCS-4, SOCS-5, SOCS-6, SOCS-7 remain poorly understood (6). On the basis of structural considerations, it would be expected that SOCS-4, -5, -6, and -7, like SOCS-1, SOCS-2, SOCS-3 and CIS, act to negatively regulate signal transduction (4), but it is uncertain which specific cytokine is involved (7-9).Synonyms: SOCS-4, SOCS-7, SOCS7, Suppressor of cytokine signaling 4, Suppressor of cytokine signaling 7

Gen-ID: 122809

NCBI Accession: NP_543143

UniProt: Q8WXH5

Pathways: JAK-STAT Signalweg, EGFR Signaling Pathway