EDNRB Antikörper (Middle Region)

Produktnummer ABIN1107094

Produktdetails anti-EDNRB Antikörper

Target: EDNRB (Endothelin Receptor Type B (EDNRB))

Bindungsspezifität: AA 244-258, Middle Region

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EDNRB Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Spezifität: This antibody detects Endothelin B Receptor. No cross reactivity with other proteins.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Immunogen Affinity Chromatography

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of Human EDNR-B (244-258aa).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Buffer: 5 mg BSA, 0.9 mg Nacl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal and 0.05 mg Sodium Azide

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains Sodium azide and Thimerosal (Merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu EDNRB

Target: EDNRB (Endothelin Receptor Type B (EDNRB))

Andere Bezeichnung: Endothelin B Receptor (EDNRB Produkte)

Synonyme: ABCDS antikoerper, ET-B antikoerper, ET-BR antikoerper, ETB antikoerper, ETBR antikoerper, ETRB antikoerper, HSCR antikoerper, HSCR2 antikoerper, WS4A antikoerper, Ednra antikoerper, Etb antikoerper, ETR-b antikoerper, ETb antikoerper, Sox10m1 antikoerper, EDNRB antikoerper, abcds antikoerper, etb antikoerper, etrb antikoerper, hscr antikoerper, hscr2 antikoerper, endothelin receptor type B antikoerper, EDNRB antikoerper, Ednrb antikoerper, ednrb antikoerper

Hintergrund: Endothelin Receptor B (EDNR-B), also called endothelin receptor, nonselective type (ETB, ETRB). It is a G-protein-coupled receptor with seven transmembrane domains which is required for the development of melanocytes and enteric neurons and migration of melanoblasts and enteric neuroblasts. The EDNRB gene spans 24 kilobases and consists of seven exons and six introns.This gene was expressed in human glaucomatous optic nerves and mapped to 13q22. The cDNA fragment for horse EDNRB contained a 1329 bp open reading frame which encoded 443 amino acid residues. The predicted amino acid sequence was 89, 91 and 85 % identical to human, bovine and mouse as well as rat EDNRB respectively, but only 55 % identical to the human, bovine and rat endothelin A receptor (EDNRA). EDNRB plays an essential role in the normal development of two neural crest-derived cell lineages, epidermal melanocytes and enteric neurons in three mammalian species--humans, mice, and rats. The EDNRB-deficient rat may also prove valuable in defining the postnatal physiologic role of this receptor.Synonyms: ABCDS, EDNRB, ET-B, ET-BR, ETB, ETBR, ETRB, Endothelin receptor non-selective type, HSCR, HSCR2, WS4A, endothelin receptor type B

Gen-ID: 1910

NCBI Accession: NP_000106

UniProt: P24530

Pathways: Cellular Response to Molecule of Bacterial Origin, cAMP Metabolic Process