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CDKN1B Antikörper
CDKN1B
Reaktivität: Human, Maus, Ratte
WB, IF
Wirt: Maus
Monoclonal
IMD-27
unconjugated
Produktnummer ABIN1106657
Produktdetails anti-CDKN1B Antikörper
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Target
Alle CDKN1B Antikörper anzeigen
CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Reaktivität
Alle Reaktivitäten für CDKN1B Antikörper
Human, Maus, Ratte
Wirt
Alle Wirte für CDKN1B Antikörper
Maus
Klonalität
Alle Klonalitäten für CDKN1B Antikörper
Monoklonal
Konjugat
Alle Konjugate für CDKN1B Antikörper
Dieser CDKN1B Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CDKN1B Antikörper
Western Blotting (WB), Immunofluorescence (IF)
Spezifität
This antibody reacts to CDKN1B.
Aufreinigung
Affinity chromatography
Immunogen
recombinant rodent p27Kip1 protein
Klon
IMD-27
Isotyp
IgG1
Top Product
Discover our top product CDKN1B Primärantikörper
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Rekonstitution
Restore with 1.2 % sodium acetate or neutral PBS
Konzentration
0,1 mg/mL
Buffer
1.2 % sodium acetate, with 2 mg BSA and 0.01 mg sodium azide as preservative.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Informationen zur Lagerung
Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Details zu CDKN1B
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Target
CDKN1B
(Cyclin-Dependent Kinase Inhibitor 1B (p27, Kip1) (CDKN1B))
Andere Bezeichnung
CDKN1B / KIP1 (CDKN1B Produkte )
Synonyme
CDKN4 antikoerper, KIP1 antikoerper, MEN1B antikoerper, MEN4 antikoerper, P27KIP1 antikoerper, cdkn1b antikoerper, sb:cb611 antikoerper, wu:fb63g10 antikoerper, wu:fb64g10 antikoerper, wu:fe18e03 antikoerper, CDKN1B antikoerper, Kip1 antikoerper, p27 antikoerper, FAM14D antikoerper, ISG12 antikoerper, ISG12A antikoerper, P27 antikoerper, Cdki1b antikoerper, AA408329 antikoerper, AI843786 antikoerper, p27Kip1 antikoerper, cdkn1bl antikoerper, cyclin dependent kinase inhibitor 1B antikoerper, cyclin-dependent kinase inhibitor 1Bb antikoerper, interferon alpha inducible protein 27 antikoerper, cyclin-dependent kinase inhibitor 1B antikoerper, cyclin-dependent kinase inhibitor 1Ba antikoerper, CDKN1B antikoerper, cdkn1bb antikoerper, IFI27 antikoerper, Cdkn1b antikoerper, cdkn1ba antikoerper
Hintergrund
P27(kip1), also known as cyclin dependent kinase inhibitor 1B(CDKN1B), is a major target of AFX-like forkhead proteins. CDKN1B (p27) belongs to the Cip/Kip family and functions as an important cell cycle gatekeeper.Phosphorylation leads to the ubiquitination and degradation of CDKN1B. P27(kip1) mapped to 12p13. An increase in p27 causes proliferating cells to exit from the cell cycle, and a decrease in p27 is necessary for quiescent cells to resume division. Abnormally low amounts of p27 are associated with pathological states of excessive cell proliferation, especially cancers. Overexpression of p27Kip1 lengthens the G1 phase in a mouse model that targets inducible gene expression to central nervous system progenitor cells.Synonyms: Cyclin-dependent kinase inhibitor 1B, Cyclin-dependent kinase inhibitor p27, p27Kip1
Gen-ID
1027
NCBI Accession
NP_004055
UniProt
P46527
Pathways
Zellzyklus , Fc-epsilon Rezeptor Signalübertragung , EGFR Signaling Pathway , Neurotrophin Signalübertragung , Positive Regulation of Peptide Hormone Secretion , Negative Regulation of Hormone Secretion , Sensory Perception of Sound , Mitotic G1-G1/S Phases , DNA Replication , Positive Regulation of Endopeptidase Activity , Synthesis of DNA , Autophagie
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