TLR2 Antikörper

Produktnummer ABIN7101942

Produktdetails anti-TLR2 Antikörper

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR2 Antikörper ist unkonjugiert

Applikation: Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Spezifität: Monoclonal antibody mT2.7 reacts with mouse Toll-like receptor 2 (TLR2). The monoclonal antibody mT2.7 stained overexpressed, as well as endogenous cell surface- and intercellular TLR2. The antibody does not affect cell activation through TLR2.

Kreuzreaktivität (Details): Species reactivity (tested):Mouse.

Aufreinigung: Purified

Klon: MTL2-7

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0,1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0,1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu TLR2

Target: TLR2 (Toll-Like Receptor 2 (TLR2))

Andere Bezeichnung: CD282 / TLR2 (TLR2 Produkte)

Synonyme: CD282 antikoerper, TIL4 antikoerper, Ly105 antikoerper, toll like receptor 2 antikoerper, toll-like receptor 2 antikoerper, TLR2 antikoerper, Tlr2 antikoerper, tlr2 antikoerper

Hintergrund: Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2.Synonyms: Toll-like receptor 2

Gen-ID: 9606

UniProt: O60603

Pathways: TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades