POMC Antikörper

Produktnummer ABIN1105257

Produktdetails anti-POMC Antikörper

Target: POMC (Proopiomelanocortin (POMC))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser POMC Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: Specific for Synacthen (1-24 ACTH). Reacts with ACTH (a.a. 1-17) and does not cross-react with CLIP (ACTH 17-39). It cross-reacts with Rat N-terminal ACTH.

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Purified

Immunogen: Keyhole Limpet Haemocyanin conjugated Human ACTH (1-17)

Klon: 57

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) -20 °C for longer.

Details zu POMC

Target: POMC (Proopiomelanocortin (POMC))

Andere Bezeichnung: POMC (POMC Produkte)

Synonyme: MSH antikoerper, ACTH antikoerper, pomc antikoerper, SI:bZ36D5.1 antikoerper, SI:bZ36D5.4 antikoerper, si:bz36d5.2 antikoerper, BE antikoerper, Beta-LPH antikoerper, Clip antikoerper, Gamma-LPH antikoerper, Npp antikoerper, Pomc-1 antikoerper, Pomc1 antikoerper, alpha-MSH antikoerper, alphaMSH antikoerper, beta-MSH antikoerper, gamma-MSH antikoerper, CLIP antikoerper, LPH antikoerper, NPP antikoerper, POC antikoerper, Pomc2 antikoerper, proopiomelanocortin a antikoerper, pro-opiomelanocortin-alpha antikoerper, proopiomelanocortin antikoerper, pomca antikoerper, Pomc antikoerper, POMC antikoerper

Hintergrund: ACTH (Synacthen) which, as a synthetic analogue of naturally-occurring Adrenocorticotropic Hormone, can be used to measure adrenal reserve and for the diagnosis of adrenal insufficiency by acute adrenocortical stimulation. ACTH, released from the anterior pituitary gland in response to corticotropin-releasing hormone from the hypothalamus, acts on the adrenal cortex to stimulate the production of corticosteroids such as cortisol, involved in the response to stress. Studies have shown that the administration of 1-24 ACTH increases blood pressure, believed to be attributed to an increase in ACTH-stimulated cortisol secretion, in association with increased cardiac output.Synonyms: Adrenocorticotropic hormone, Corticotropin, POMC

Gen-ID: 5443

NCBI Accession: NP_000930

UniProt: P01189

Pathways: Metabolism of Steroid Hormones and Vitamin D, Peptide Hormone Metabolism, Hormone Activity, Feeding Behaviour