PRICKLE1 Antikörper (C-Term)

Produktnummer ABIN1077370

Produktdetails anti-PRICKLE1 Antikörper

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Bindungsspezifität: C-Term

Reaktivität: Human, Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRICKLE1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Spezifität: Multiple isoforms of PRICKLE1 are known to exist. PRICKLE1 antibody is predicted to not cross-react with other PRICKLE protein family members.

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: PRICKLE1 antibody was raised against a AA 19 synthetic peptide near the carboxy terminus of human PRICKLE1.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: PRICKLE1 antibody can be used for detection of PRICKLE1 by Western blot at 1 μg/mL. Antibody can also be used for immunofluorescence starting at 20 μg/mL. For immunofluorescence start at 20 μg/mL. Optimal dilutions for each application to be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: PRICKLE1 antibody can be stored at 4 °C for three months and -20 °C, stable for up to one year.

Haltbarkeit: 12 months

Details zu PRICKLE1

Target: PRICKLE1 (Prickle-Like Protein 1 (PRICKLE1))

Andere Bezeichnung: PRICKLE1 (PRICKLE1 Produkte)

Synonyme: EPM1B antikoerper, RILP antikoerper, Rilp antikoerper, 1110058P22Rik antikoerper, AW215793 antikoerper, Prickle antikoerper, mpk1 antikoerper, XPk antikoerper, pk-B antikoerper, prickle antikoerper, prickle-B antikoerper, Prickle-b antikoerper, prickle planar cell polarity protein 1 antikoerper, prickle planar cell polarity protein 1 L homeolog antikoerper, prickle planar cell polarity protein 1 S homeolog antikoerper, PRICKLE1 antikoerper, Prickle1 antikoerper, prickle1.L antikoerper, prickle1.S antikoerper

Hintergrund: Synonyms:
REST, NRSF-interacting LIM domain protein 1, RILP, EPM1B

PRICKLE1 is a Disheveled-associated protein that serves as a nuclear translocation receptor for REST/NRSF and REST4. It contains three N-terminal LIM domains and three C-terminal nuclear localization signals. It localizes to the cytoplasm, as well as to the nuclear membrane and expressed at higher levels in placenta. PRICKLE1 is a negative regulator of the Wnt / beta-catenin signaling pathway and is a putative tumor suppressor in human HCCs. Defects in the gene encoding PRICKLE1 are associated with autosomal recessive progressive myoclonic epilepsy.

Gen-ID: 144165

NCBI Accession: NP_694571

Pathways: WNT Signalweg, Regulation of Muscle Cell Differentiation, Tube Formation, Skeletal Muscle Fiber Development, Protein targeting to Nucleus