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anti-Human ELAVL1 Antikörper:
anti-Rat (Rattus) ELAVL1 Antikörper:
anti-Mouse (Murine) ELAVL1 Antikörper:
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Human Monoclonal ELAVL1 Primary Antibody für ChIP, IP - ABIN577055
Li, Lu, Dai, Torregroza, Hla, Evans: Elavl1a regulates zebrafish erythropoiesis via posttranscriptional control of gata1. in Blood 2014
Show all 3 Pubmed References
Human Monoclonal ELAVL1 Primary Antibody für IF, IHC (p) - ABIN560725
Kani, Faca, Hughes, Zhang, Fang, Shahbaba, Luethy, Erde, Schmidt, Pitteri, Zhang, Katz, Gross, Plevritis, McIntosh, Jain, Hanash, Agus, Mallick: Quantitative proteomic profiling identifies protein correlates to EGFR kinase inhibition. in Molecular cancer therapeutics 2012
HuR is required for pancreatic ductal adenocarcinoma tumor growth.
Transgenic expression of HuR in astrocytes accentuated neuronal injury and other secondary features of spinal cord injury including increased vascular permeability and astrocyte activation.
HuR may be involved in the pathogenesis of glaucoma.
Findings reveal a new mechanism whereby HUR protects NONO (zeige NONO Antikörper) from mir320-mediated degradation upon UVC exposure and identify a new component within the complex network of players underlying the DNA damage response adding mir320a to the list of p53 (zeige TP53 Antikörper)-regulated targets upon genotoxic stress.
ectopic expression of HuR promotes breast cancer cell proliferation and survival by directly binding to and stabilizing CDK3 (zeige CDK3 Antikörper) mRNA.
New ELAVL1-TYK2 (zeige TYK2 Antikörper) fusion gene is oncogenic in acute myeloid leukemia (zeige BCL11A Antikörper).
High expression of HuR is correlated with thyroid cancer.
Folate deficiency impaired spermatogenesis and reduced sperm concentration may partly due to inhibiting the expression of the three key molecules (Esr1 (zeige ESR1 Antikörper), Cav1 (zeige CAV1 Antikörper) and Elavl1) essential for sperm production.
these studies demonstrate that HuR knockdown in triple-negative breast cancer cells elicits oxidative stress and DNA damage resulting in radiosensitization
LncRNA-AK058003 can reduce the expression of mRNA stabilizing protein HuR and act as a precursor of miR-15a to suppress gamma-synuclein-mediated cell proliferation and the metastasis of hepatocellular carcinoma.
STAU1 (zeige STAU1 Antikörper) & STAU2 & ELAVL1 mRNAs & proteins were detected throughout cow preimplantation development (zeige MTA2 Antikörper) from the germinal vesicle (GV) oocyte to the blastocyst stage; ELAVL2 (zeige ELAVL2 Antikörper) mRNAs were detectable from the GV to the morula stage; ELAVL2 (zeige ELAVL2 Antikörper) protein was in all stages
this study reveals a posttranscriptional regulatory mechanism by which RNA-binding protein (zeige RBM24 Antikörper) Elavl1a regulates embryonic erythropoiesis by maintaining appropriate levels of gata1 (zeige GATA1 Antikörper) expression.
Data report that HuR negatively regulates CUGBP1 (zeige CELF1 Antikörper) expression by relocalization to the cytoplasm from the nucleus, which is controlled by different post-transcriptional phosphorylation signaling pathways. These results suggest that HuR acts upstream of CUGBP1 (zeige CELF1 Antikörper) in regulating the expression of genes related to acute myocardial infarction.
Depletion of CLPABP disturbed the normal subcellular localization of HuR to stress granules, and overexpression of CLPABP induced instability of leptin (zeige LEP Antikörper) mRNA by inhibiting HuR function.
Data (including data from studies using knockout mice or cells from knockout mice) suggest HuR post-transcriptionally regulates Ccr6 (zeige CCR6 Antikörper) expression by binding to and stabilizing Ccr6 (zeige CCR6 Antikörper) mRNA and by promoting Ccr6 (zeige CCR6 Antikörper) translation in helper T-cells; knock-out of HuR reduces Ccr6 (zeige CCR6 Antikörper) expression on helper T-cells, impairs their migration to CNS, and prevents experimental autoimmune encephalomyelitis. (Ccr6 (zeige CCR6 Antikörper) = C-C chemokine receptor type 6 (zeige CCR6 Antikörper))
Taken together, our results indicate that HuR activation is an early event in familial adenomatosis polyposis (FAP (zeige FAP Antikörper))--adenoma but is not present in inflammatory bowel disease (IBD)-dysplasia. Furthermore, our results offer a preclinical proof of concept for HuR inhibition as an effective means of FAP (zeige FAP Antikörper) chemoprevention, with caution advised in the setting of IBD
findings indicate a previously unknown interaction between GSK3beta and ELAV-1 during acute respiratory distress syndrome , and suggest the inhibition of the ELAV-1- GSK3beta pathways as a novel acute respiratory distress syndrome treatment approach.
HuR plays a central role in regulating nuclear import of proteins.
These results indicate that HuR promotes early intestinal mucosal repair after injury by increasing Cdc42 (zeige CDC42 Antikörper) translation.
This study uncovers an anti-sense lncRNA (APOA4 (zeige APOA4 Antikörper)-AS), which is co-expressed with APOA4 (zeige APOA4 Antikörper), and concordantly and specifically regulates APOA4 (zeige APOA4 Antikörper) expression both in vitro and in vivo with the involvement of HuR.
These results suggest that the post-transcriptional regulation of ATX (zeige ENPP2 Antikörper) expression by HuR and AUF1 (zeige HNRNPD Antikörper) modulates cancer cell migration.
Results show that HuR is a key regulator of many genes that make up the molecular signature of activated microglia, including increased production of proinflammatory cytokines, chemokines, and migration-associated factors
The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy.
ELAV-like protein 1
, Hu antigen R
, embryonic lethal, abnormal vision, drosophila, homolog-like 1
, hu-antigen R
, ELAV like 1
, ELAV-like 1 (Hu antigen R)
, elav-related A
, embryonic lethal, abnormal vision-related A
, ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R)
, HU-antigen A
, elav-like generic protein