ELAVL1 Antikörper (Internal Region)

Produktnummer ABIN6261510

Produktdetails anti-ELAVL1 Antikörper

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Bindungsspezifität: Internal Region

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ELAVL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)

Spezifität: ELAVL1 Antibody detects endogenous levels of total ELAVL1.

Homologie: Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken,Xenopus

Aufreinigung: The antiserum was purified by peptide affinity chromatography using SulfoLink^TM Coupling Resin (Thermo Fisher Scientific).

Immunogen: A synthesized peptide derived from human ELAVL1, corresponding to a region within the internal amino acids.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-1:2000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C. Stable for 12 months from date of receipt.

Haltbarkeit: 12 months

Details zu ELAVL1

Target: ELAVL1 (ELAV (Embryonic Lethal, Abnormal Vision, Drosophila)-Like 1 (Hu Antigen R) (ELAVL1))

Andere Bezeichnung: ELAVL1 (ELAVL1 Produkte)

Synonyme: ELAV1 antikoerper, HUR antikoerper, Hua antikoerper, MelG antikoerper, HuR antikoerper, 2410055N02Rik antikoerper, W91709 antikoerper, elra antikoerper, fa25f08 antikoerper, fb59a02 antikoerper, fc60g02 antikoerper, hua antikoerper, wu:fa25f08 antikoerper, wu:fb59a02 antikoerper, wu:fc60g02 antikoerper, zHuA antikoerper, Elavl1 antikoerper, Xel-1 antikoerper, elav1 antikoerper, elrA antikoerper, hur antikoerper, melg antikoerper, p36 antikoerper, ElrA antikoerper, elavl1 antikoerper, elavl1-a antikoerper, elavl1-b antikoerper, ELAV like RNA binding protein 1 antikoerper, ELAV-like protein 1 antikoerper, ELAV (embryonic lethal, abnormal vision)-like 1 (Hu antigen R) antikoerper, ELAV like RNA binding protein 1a antikoerper, ELAV like RNA binding protein 1 L homeolog antikoerper, ELAV like RNA binding protein 1 S homeolog antikoerper, ELAVL1 antikoerper, Elavl1 antikoerper, elav1 antikoerper, elavl1a antikoerper, elavl1.L antikoerper, elavl1.S antikoerper

Hintergrund:

Description: RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462). Involved in embryonic stem cells (ESCs) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESCs differentiation (By similarity). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:8626503, PubMed:17632515, PubMed:18285462, PubMed:23519412). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity).

Gene: ELAVL1

Molekulargewicht: 36kDa

Gen-ID: 1994

UniProt: Q15717

Pathways: AMPK Signaling