anti-Human TLR9 Antikörper für Enzyme Immunoassay

Recommended TLR9 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 9 (TLR9) Antikörper
  • CD289
  • toll like receptor 9
  • toll-like receptor 9
  • TLR9
  • Tlr9
Epitop
AA 1-815, Extracellular Domain, N-Term
39
31
14
13
12
11
8
7
7
6
6
6
5
4
4
4
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Hund, Human, Maus
262
147
56
35
23
20
7
5
3
2
2
2
2
2
1
1
1
Wirt
Maus
144
123
35
14
4
3
Klonalität
Monoklonal
Konjugat
Dieser TLR9 Antikörper ist konjugiert mit FITC
27
24
17
8
6
6
5
4
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
228
163
132
109
88
39
36
36
14
7
6
6
5
5
5
3
3
3
2
Hersteller
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Bilder

Produktnummer ABIN1106226
$ 489.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
4 ABIN1106225 EIA IHC (fro) IF IHC (p) WB Biotin Mouse IgG2a AA 1-815, Extracellular Domain, N-Term Anmelden zum Anzeigen 5G5 7
4 ABIN784145 EIA IF IHC (p) WB Goat IgG AA 204-224, N-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN5555342 EIA IF IHC (p) WB Rabbit IgG C-Term Anmelden zum Anzeigen Polyclonal 0
1 ABIN5555343 EIA IF WB Rabbit IgG Center Anmelden zum Anzeigen Polyclonal 0
1 ABIN187334 EIA FACS IHC (fro) IHC (p) WB Mouse IgG2a Anmelden zum Anzeigen 5G5 0

General

Antigen Toll-Like Receptor 9 (TLR9) Antikörper
Epitop AA 1-815, Extracellular Domain, N-Term
(39), (31), (14), (13), (12), (11), (8), (7), (7), (6), (6), (6), (5), (4), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Hund, Human, Maus
(262), (147), (56), (35), (23), (20), (7), (5), (3), (2), (2), (2), (2), (2), (1), (1), (1)
Wirt Maus
(144), (123), (35), (14), (4), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR9 Antikörper ist konjugiert mit FITC
(27), (24), (17), (8), (6), (6), (5), (4), (4), (4), (3), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(228), (163), (132), (109), (88), (39), (36), (36), (14), (7), (6), (6), (5), (5), (5), (3), (3), (3), (2)
Pubmed 7 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR9 Antikörper

Target Details TLR9 Anwendungsinformationen Handhabung Referenzen für anti-TLR9 Antikörper (ABIN1106226) Bilder
Spezifität The monoclonal antibody 5G5 recognizes human Toll-like receptor 9.
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse, canine
Reinigung Protein G
Immunogen Purified fusion protein of extracellular domain of human TLR9 (AA 1-815) and human IgGFc
Klon 5G5
Isotyp IgG2a
Plasmids, Primers & others

Target Details TLR9

Produktdetails anti-TLR9 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR9 Antikörper (ABIN1106226) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD289 / TLR9 (TLR9 Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens. Whereas most TLRs are expressed on the cell surface, TLR9 is expressed intracellularly within one or more endosomal compartments and recognizes nucleic acids. TLR9 detects a rather subtle difference in the DNA of vertebrates compared with that of pathogens. Vertebrate genomic DNAs have mostly methylated CpG dinucleotides where bacterial and viral DNAs have unmethylated CpG dinucleotides. TLR9 undergoes relocation from endoplasmic reticulum to CpG-ODN-containing endosomes. In these endosomes TLR9 becomes a functional receptor after proteolytic cleavage. TLR9 exists as a preformed homodimer and CpG-ODN binding promotes its conformational change, bringing the cytoplasmic TIR-like domains close to each other. This allows a recruitment of the key adapter protein MyD88 which initiates a signalling cascade. The only human immune cell types known to constitutively express TLR9 and to be activated by CpG ODN are pDCs and B cells. TLR9 triggering induces an activation phenotype in the B cells and pDCs, characterized by the expression of costimulatory molecules, resistance to apoptosis, and induces Th1-type immune response profiles.Synonyms: Toll-like receptor 9, UNQ5798/PRO19605
Gen-ID 81897
NCBI Accession NP_112455
UniProt Q9EQU3
Pathways TLR Signalweg, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR9 Antikörper Target Details TLR9 Handhabung Referenzen für anti-TLR9 Antikörper (ABIN1106226) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR9 Antikörper Target Details TLR9 Anwendungsinformationen Referenzen für anti-TLR9 Antikörper (ABIN1106226) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 1 % bovine serum albumin, 0.02 % sodium azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-TLR9 Antikörper (ABIN1106226)

Produktdetails anti-TLR9 Antikörper Target Details TLR9 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Jeong, Choi, Cho, Lee, Oh, Park, Cho, Lee, Kim, Han, Choi, Chung: "Chronic gastrointestinal symptoms and quality of life in the Korean population." in: World journal of gastroenterology : WJG, Vol. 14, Issue 41, pp. 6388-94, 2008

Burgener, Jungi: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, 2008

Tokumasa, Suto, Kagami, Furuta, Hirose, Watanabe, Saito, Shimoda, Iwamoto, Nakajima: "Expression of Tyk2 in dendritic cells is required for IL-12, IL-23, and IFN-gamma production and the induction of Th1 cell differentiation." in: Blood, Vol. 110, Issue 2, pp. 553-60, 2007

Pratesi, Petrangolini, Tortoreto, Addis, Belluco, Rossini, Selleri, Rumio, Menard, Balsari: "Therapeutic synergism of gemcitabine and CpG-oligodeoxynucleotides in an orthotopic human pancreatic carcinoma xenograft." in: Cancer research, Vol. 65, Issue 14, pp. 6388-93, 2005

Rutz, Metzger, Gellert, Luppa, Lipford, Wagner, Bauer: "Toll-like receptor 9 binds single-stranded CpG-DNA in a sequence- and pH-dependent manner." in: European journal of immunology, Vol. 34, Issue 9, pp. 2541-50, 2004

Rumio, Besusso, Palazzo, Selleri, Sfondrini, Dubini, Ménard, Balsari: "Degranulation of paneth cells via toll-like receptor 9." in: The American journal of pathology, Vol. 165, Issue 2, pp. 373-81, 2004

Ahmad-Nejad, Häcker, Rutz, Bauer, Vabulas, Wagner: "Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments." in: European journal of immunology, Vol. 32, Issue 7, pp. 1958-68, 2002

Bilder

Produktdetails anti-TLR9 Antikörper Target Details TLR9 Anwendungsinformationen Handhabung Referenzen für anti-TLR9 Antikörper (ABIN1106226) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Toll-Like Receptor 9 (TLR9) (AA 1-815), (Extracellular Domain), (N-Term) antibody (FITC) (ABIN1106226) anti-Toll-Like Receptor 9 (TLR9) (AA 1-815), (Extracellular Domain), (N-Term) antibody (FITC)