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USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP14 Antikörper (88) und USP14 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.
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Usp14 and Ube3c (zeige UBE3C Proteine) cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.
our results demonstrated that vimentin (zeige VIM Proteine) in human GC tissues and cell lines was upregulated due to its de-ubiquitination after interactions with USP14 and miR (zeige MLXIP Proteine)-320a, which could promote the aggressiveness of GC cells.
Study detected elevated USP14 expression at both mRNA and protein levels, and was significantly associated with distant metastasis.
These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.
Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma
our report demonstrates significant value in targeting USP14/UCHL5 (zeige UCHL5 Proteine) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation
USP14 promotes prostate cancer progression.
without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.
USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (zeige BECN1 Proteine)
USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.
The homeostasis of Ubiquitin in USP14-/-mouse embryonic fibroblasts was markedly perturbed because of facilitated clearance of Ubiquitin.
analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes
USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.
Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.
USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.
Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.
Data indicate that increased levels of phosphorylated tau correlated with the onset of axonal varicosities in the ubiquitin-specific protease 14 (Usp14)-deficient mice.
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
deubiquitinating enzyme 14
, tRNA-guanine transglycosylase, 60-kD subunit
, ubiquitin carboxyl-terminal hydrolase 14
, ubiquitin specific protease 14 (tRNA-guanine transglycosylase)
, ubiquitin thioesterase 14
, ubiquitin thiolesterase 14
, ubiquitin-specific processing protease 14
, ubiquitin-specific-processing protease 14
, ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase)
, ubiquitin domain-containing protein
, dUB-type TGT for deubiquitinating enzyme
, ubiquitin specific protease 14
, universal stress protein
, queuine tRNA-ribosyltransferase
, ubiquitin carboxyl-terminal hydrolase 14-like