Ubiquitin Specific Peptidase 14 Proteine (USP14)

USP14 encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. Zusätzlich bieten wir Ihnen USP14 Antikörper (88) und USP14 Kits (6) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
USP14 9097 P54578
USP14 59025 Q9JMA1
Ratte USP14 USP14 291796  
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Top USP14 Proteine auf antikoerper-online.de

Showing 10 out of 15 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 60 Days
$9,797.11
Details
Escherichia coli (E. coli) Human His tag Validation with Western Blot 10 μg Anmelden zum Anzeigen 8 bis 11 Tage
$504.90
Details
Escherichia coli (E. coli) Human His tag   50 μg Anmelden zum Anzeigen 4 Days
$330.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Escherichia coli (E. coli) Human His tag 100 μg Anmelden zum Anzeigen 15 bis 19 Tage
$400.00
Details
Hefe Caenorhabditis elegans His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,384.33
Details
Hefe Kaninchen His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,397.17
Details
Hefe Schimpanse His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,397.17
Details

USP14 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Human , , ,
, ,
Mouse (Murine)

Weitere Proteine zu Ubiquitin Specific Peptidase 14 (USP14) Interaktionspartnern

Human Ubiquitin Specific Peptidase 14 (USP14) Interaktionspartner

  1. Usp14 and Ube3c (zeige UBE3C Proteine) cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  2. our results demonstrated that vimentin (zeige VIM Proteine) in human GC tissues and cell lines was upregulated due to its de-ubiquitination after interactions with USP14 and miR (zeige MLXIP Proteine)-320a, which could promote the aggressiveness of GC cells.

  3. Study detected elevated USP14 expression at both mRNA and protein levels, and was significantly associated with distant metastasis.

  4. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  5. Ubiquitin-specific protease 14 regulates cell proliferation and apoptosis in oral squamous cell carcinoma

  6. our report demonstrates significant value in targeting USP14/UCHL5 (zeige UCHL5 Proteine) with VLX1570 in drug-resistant Waldenstrom macroglobulinemia (WM) and carries a high potential for clinical translation

  7. USP14 promotes prostate cancer progression.

  8. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  9. USP14 regulates autophagy by negatively controlling K63 ubiquitination of Beclin 1 (zeige BECN1 Proteine)

  10. USP14 plays an important role in the progression and metastasis of esophageal squamous cell carcinoma.

Mouse (Murine) Ubiquitin Specific Peptidase 14 (USP14) Interaktionspartner

  1. the data indicate that functional Usp14 enhances direct Antigen presentation, preferentially of defective ribosomal product-derived peptides, suggesting that the processing of defective ribosomal product-derived peptides is in some ways different from other forms of Antigen.

  2. The homeostasis of Ubiquitin in USP14-/-mouse embryonic fibroblasts was markedly perturbed because of facilitated clearance of Ubiquitin.

  3. Usp14 and Ube3c (zeige UBE3C Proteine) cycle together on and off proteasomes, and the presence of ubiquitinated substrates promotes their association. This mechanism enables proteasome activity to adapt to the supply of substrates.

  4. analysis of the molecular mechanisms through which CBP stability is regulated by FBXL19 and USP14, which results in the modulation of chromatin remodeling and the expression of cytokine-encoding genes

  5. These findings suggested that USP14 induces NF-kappaB activity and ERK1/2 phosphorylation triggered by microbial infection.

  6. without a ubiquitinated substrate present, Usp14 suppresses multiple proteasomal activities, especially basal ATP consumption and degradation of non-ubiquitinated proteins. These allosteric effects thus reduce ATP hydrolysis by inactive proteasomes and nonspecific proteolysis and enhance proteasomal specificity for ubiquitinated proteins.

  7. USP14's catalytic activity is required for nervous system structure and function and has an ongoing role in NMJ synaptic transmission. USP14 regulation of the ubiquitination status of protein kinases, coordinates NMJ intracellular signaling pathways.

  8. Overexpression of the Usp14 reduces cellular aggregates in mutant Htt-expressing cells mainly via the ubiquitin proteasome system.

  9. USP14 modulates hippocampal short-term plasticity and vesicle number independent of its deubiquitinating activity.

  10. Differences in genetic background were shown to affect ubiquitin expression and dramatically alter the phenotypes caused by USP14 deficiency.

USP14 Protein Überblick

Protein Überblick

This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. Mice with a mutation that results in reduced expression of the ortholog of this protein are retarded for growth, develop severe tremors by 2 to 3 weeks of age followed by hindlimb paralysis and death by 6 to 10 weeks of age. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Genbezeichner und Symbole assoziert mit USP14

  • ubiquitin specific peptidase 14 (USP14)
  • peptidase C19 family protein (usp14)
  • ubiquitin specific peptidase 14 (Usp14)
  • ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) (usp14)
  • ubiquitin specific protease 14 (Bm1_28765)
  • ubiquitin specific peptidase 14 S homeolog (usp14.S)
  • ubiquitin specific peptidase 14 (usp14)
  • universal stress protein (RR_RS06480)
  • Ubiquitin carboxyl-terminal hydrolase 14 (usp-14)
  • 2610005K12Rik Protein
  • 2610037B11Rik Protein
  • AW107924 Protein
  • ax Protein
  • C78769 Protein
  • DDBDRAFT_0202821 Protein
  • DDBDRAFT_0237695 Protein
  • DDB_0202821 Protein
  • DDB_0237695 Protein
  • MGC69343 Protein
  • MGC81945 Protein
  • tgt Protein
  • USP14 Protein
  • wu:fk63d09 Protein
  • zgc:55949 Protein

Bezeichner auf Proteinebene für USP14

deubiquitinating enzyme 14 , tRNA-guanine transglycosylase, 60-kD subunit , ubiquitin carboxyl-terminal hydrolase 14 , ubiquitin specific protease 14 (tRNA-guanine transglycosylase) , ubiquitin thioesterase 14 , ubiquitin thiolesterase 14 , ubiquitin-specific processing protease 14 , ubiquitin-specific-processing protease 14 , ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) , ubiquitin domain-containing protein , ataxia , dUB-type TGT for deubiquitinating enzyme , ubiquitin specific protease 14 , universal stress protein , queuine tRNA-ribosyltransferase , ubiquitin carboxyl-terminal hydrolase 14-like

GENE ID SPEZIES
9097 Homo sapiens
100090009 Ornithorhynchus anatinus
8617881 Dictyostelium discoideum AX4
59025 Mus musculus
291796 Rattus norvegicus
335736 Danio rerio
455325 Pan troglodytes
505106 Bos taurus
6100653 Brugia malayi
421063 Gallus gallus
447733 Xenopus laevis
448110 Xenopus (Silurana) tropicalis
480182 Canis lupus familiaris
698087 Macaca mulatta
3130489 Haloarcula marismortui ATCC 43049
100009078 Oryctolagus cuniculus
100013535 Monodelphis domestica
100394297 Callithrix jacchus
100473541 Ailuropoda melanoleuca
100586916 Nomascus leucogenys
175105 Caenorhabditis elegans
Ausgewählte Anbieter für USP14 Proteine (USP14)
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