anti-Sclerostin (SOST) Antikörper

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Kits (63) und Sclerostin Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SOST 50964 Q9BQB4
SOST 74499 Q99P68
SOST 80722 Q99P67
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Top anti-Sclerostin Antikörper auf antikoerper-online.de

Showing 10 out of 128 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-SOST Antibody (N-term) Pab (ABIN390193) in mouse liver tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody (1:60 dilution). Formalin-fixed and paraffin-embedded human breast carcinoma tissue reacted with SOST antibody (N-term)(ABIN390193), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of SOST Antibody (Center) (ABIN390194) in mouse lung tissue lysates (35 µg/lane). SOST (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human hepatocarcinoma tissue reacted with SOST antibody (Center)(ABIN390194), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Maus Ziege Unkonjugiert IHC, WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage
$815.83
Details
Human Kaninchen Unkonjugiert WB SOST Antibody (N-term)  western blot analysis in mouse liver tissue lysates (35ug/lane).This demonstrates the SOST antibody detected the SOST protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human kidney labeled with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated (ABIN1714867) at 1:200 followed by conjugation to the secondary antibody and DAB staining Lane 1: mouse lung probed with Rabbit Anti-Sclerostin Polyclonal Antibody, Unconjugated  at 1:5000 for 90 min at 37˚C. 100 μL Anmelden zum Anzeigen 14 bis 21 Tage
$306.90
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$350.00
Details
Maus Kaninchen Unkonjugiert ICC, IHC, WB Figure. Western Blot; Sample: Recombinant protein. Figure.DAB staining on IHC-P. Samples: Mouse Tissue 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$360.00
Details

SOST Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

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Am meisten referenzierte anti-Sclerostin Antikörper

  1. Human Polyclonal Sclerostin Primary Antibody für EIA, IHC (p) - ABIN358751 : Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. in The Journal of biological chemistry 2006 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal Sclerostin Primary Antibody für IHC (p), WB - ABIN390193 : Lin, Lin, Chang, Wang, Lai: Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation. in Bioelectromagnetics 2015 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen Sclerostin Interaktionspartner

Human Sclerostin (SOST) Interaktionspartner

  1. Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%

  2. serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness

  3. The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.

  4. SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway

  5. No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.

  6. Positivity of RANKL (zeige TNFSF11 Antikörper) and anti-CCP2 (zeige AGBL2 Antikörper) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (zeige TNFSF11 Antikörper) or SOST was associated with increased concentrations of the factors.

  7. Osterix (zeige SP7 Antikörper) and RUNX2 (zeige RUNX2 Antikörper) are transcriptional regulators of sclerostin in human bone

  8. Sclerostin But Not Dickkopf-1 (zeige DKK1 Antikörper) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women

  9. An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (zeige COL1A2 Antikörper).

  10. High serum levels of sclerostin and Dkk-1 (zeige DKK1 Antikörper) are associated with acute ischaemic stroke

Mouse (Murine) Sclerostin (SOST) Interaktionspartner

  1. These results show that osteocytes and/or osteoblasts secrete factors regulating beige (zeige LYST Antikörper) adipogenesis, at least in part, through the Wnt (zeige WNT2 Antikörper)-signaling inhibitor sclerostin.

  2. In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 Antikörper)+/-or Sost+/-mice

  3. loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Antikörper) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 Antikörper) activation together.

  4. humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 Antikörper).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.

  5. Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin

  6. Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.

  7. complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.

  8. In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.

  9. These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.

  10. Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (zeige WNT2 Antikörper) signaling pathway inhibition.

Sclerostin (SOST) Antigen-Profil

Protein Überblick

Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.

Genbezeichner und Symbole assoziert mit anti-Sclerostin (SOST) Antikörper

  • sclerostin (LOC100313724) Antikörper
  • sclerostin (SOST) Antikörper
  • sclerostin (Sost) Antikörper
  • 5430411E23Rik Antikörper
  • CDD Antikörper
  • LOC100313724 Antikörper
  • VBCH Antikörper

Bezeichner auf Proteinebene für anti-Sclerostin (SOST) Antikörper

sclerostin , sclerosteosis

GENE ID SPEZIES
100313724 Saccoglossus kowalevskii
50964 Homo sapiens
74499 Mus musculus
80722 Rattus norvegicus
490948 Canis lupus familiaris
100730713 Cavia porcellus
282880 Bos taurus
429784 Gallus gallus
101114123 Ovis aries
100513306 Sus scrofa
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