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Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Zusätzlich bieten wir Ihnen Sclerostin Kits (63) und Sclerostin Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal Sclerostin Primary Antibody für EIA, IHC (p) - ABIN358751
Semenov, He: LRP5 mutations linked to high bone mass diseases cause reduced LRP5 binding and inhibition by SOST. in The Journal of biological chemistry 2006
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Human Polyclonal Sclerostin Primary Antibody für IHC (p), WB - ABIN390193
Lin, Lin, Chang, Wang, Lai: Single-pulsed electromagnetic field therapy increases osteogenic differentiation through Wnt signaling pathway and sclerostin downregulation. in Bioelectromagnetics 2015
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Sclerostin increased after exercise in comparison to baseline (mean +/- SEM: 410 +/- 27 vs. 290 +/- 19 pg/mL; p < 0.001) corresponding to an increase of +44.3 +/-5.5%
serum sclerostin levels correlated positively with carotid intima-media thickness and inversely with the augmentation index, a marker of arterial stiffness
The difference of serum sclerostin levels in Ankylosing Spondylitis and Rheumatoid Arthritis patients was not significantly different from HC, indicating that the sclerostin may not associate with the development of Ankylosing Spondylitis and Rheumatoid Arthritis.
SOST gene silencing promotes the proliferation, invasion, and migration, and inhibits apoptosis of osteosarcoma cells by activating Wnt (zeige WNT2 Antikörper)/beta-catenin (zeige CTNNB1 Antikörper) signaling pathway
No difference was found in the serum sclerostin levels between the hyperthyroidism patients and healthy control.
Positivity of RANKL (zeige TNFSF11 Antikörper) and anti-CCP2 (zeige AGBL2 Antikörper) yielded significant risk for progression with negativity for both as reference. No single nucleotide polymorphism encoding TNFSF11 (zeige TNFSF11 Antikörper) or SOST was associated with increased concentrations of the factors.
Osterix (zeige SP7 Antikörper) and RUNX2 (zeige RUNX2 Antikörper) are transcriptional regulators of sclerostin in human bone
Sclerostin But Not Dickkopf-1 (zeige DKK1 Antikörper) has roles in increasing prevalence of osteoporotic fracture and lower bone mineral density in postmenopausal Korean women
An association was found between rs851054 of the SOST promoter and the fracture rate during childhood osteogenesis imperfecta (zeige COL1A2 Antikörper).
High serum levels of sclerostin and Dkk-1 (zeige DKK1 Antikörper) are associated with acute ischaemic stroke
These results show that osteocytes and/or osteoblasts secrete factors regulating beige (zeige LYST Antikörper) adipogenesis, at least in part, through the Wnt (zeige WNT2 Antikörper)-signaling inhibitor sclerostin.
In vivo muCT analysis of cortical bone at age 1 and 3 months confirmed increased thickness in Sost-/-mice, but revealed no cortical abnormalities in single Gja1 (zeige GJA1 Antikörper)+/-or Sost+/-mice
loss of BMP signaling specifically in osteocytes dramatically increases bone mass presumably through simultaneous inhibition of RANKL (zeige TNFSF11 Antikörper) and SOST, leading to osteoclast inhibition and Wnt (zeige WNT2 Antikörper) activation together.
humanized Multiple Myeloma xenograft mouse model bearing human MM cells (NOD-SCID.CB17 male mice injected intravenously with 2.5 million of MM1 (zeige PFDN5 Antikörper).S-Luc-GFP cells) demonstrated significantly higher concentrations of mouse-derived sclerostin, suggesting a microenvironmental source of sclerostin.
Protection From Glucocorticoid-Induced Osteoporosis by Anti-Catabolic Signaling in the Absence of Sost/Sclerostin
Osteocyte-derived molecule sclerostin drives bone marrow adipogenesis.
complete absence of sclerostin has only minor effects on chronic kidney disease-induced bone loss in mice.
In mice, sclerostin deficiency hastened reparative dentinogenesis after pulp injury, suggesting that the inhibition of sclerostin may constitute a promising therapeutic strategy for improving the healing of damaged pulps.
These data suggest that sclerostin plays an important role in the bone remodeling of tooth movement.
Sclerostin inhibits angiotensin II-induced aortic aneurysm and atherosclerosis via wnt (zeige WNT2 Antikörper) signaling pathway inhibition.
Sclerostin is a secreted glycoprotein with a C-terminal cysteine knot-like (CTCK) domain and sequence similarity to the DAN (differential screening-selected gene aberrative in neuroblastoma) family of bone morphogenetic protein (BMP) antagonists. Loss-of-function mutations in this gene are associated with an autosomal-recessive disorder, sclerosteosis, which causes progressive bone overgrowth. A deletion downstream of this gene, which causes reduced sclerostin expression, is associated with a milder form of the disorder called van Buchem disease.