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E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. Zusätzlich bieten wir Ihnen RFWD3 Antikörper (29) und viele weitere Produktgruppen zu diesem Protein an.
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a polymorphism in the 3'-UTR of RFWD3 had a strong association with PATN1, which affects spotting patterns in horse coat color
The results suggest that RPA phosphorylation enhances the recruitment of PRP19 to RPA-ssDNA and stimulates RPA ubiquitylation through a process requiring both PRP19 and RFWD3, thereby triggering a phosphorylation-ubiquitylation circuitry that promotes ATR activation and homologous recombination.
Single point mutations in the RPA32 subunit of RPA that abolish interaction with RFWD3 also inhibit interstrand crossling repair, demonstrating that RPA-mediated RFWD3 recruitment to stalled replication forks is important for ICL repair.
E3 ligase RFWD3 functions in timely removal and degradation of RPA (zeige RPA1 Proteine) and RAD51 (zeige RAD51 Proteine) to allow homologous recombination progression to subsequent steps following mitomycin C damage.
RFWD3-dependent ubiquitination of RPA regulates repair at stalled replication forks.
RFWD3 and RPA2 (zeige RPA2 Proteine) functionally interact and participate in replication checkpoint control
RFWD3 is recruited to sites of DNA damage and facilitates RPA-mediated DNA damage signaling and repair
Study identifies RFWD3 as a positive regulator of p53 (zeige TP53 Proteine) stability when the G(1) cell cycle checkpoint is activated and provides an explanation for how p53 (zeige TP53 Proteine) is protected from degradation in the presence of high levels of Mdm2 (zeige MDM2 Proteine).
E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.
ring finger and WD repeat domain 3
, RING finger and WD repeat domain-containing protein 3-like
, E3 ubiquitin-protein ligase RFWD3
, RING finger and WD repeat domain-containing protein 3
, RING finger protein 201