anti-Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) Antikörper

The protein encoded by PTPRN is a member of the protein tyrosine phosphatase (PTP) family. Zusätzlich bieten wir Ihnen PTPRN Kits (25) und PTPRN Proteine (18) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
PTPRN 5798 Q16849
PTPRN 19275  
PTPRN 116660 Q63259
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Top anti-PTPRN Antikörper auf antikoerper-online.de

Showing 10 out of 73 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-PTPRN Antibody Titration: </b>0.0625ug/ml<br><b>Positive Control: </b>HepG2 cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Maus Ziege Unkonjugiert ELISA, WB ABIN334423 (0.5µg/ml) staining of NIH 3T3 lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$358.02
Details
Human Kaninchen Unkonjugiert WB PTPRN Antibody (Center) (ABIN658444) western blot analysis in Jurkat cell line lysates (35 µg/lane). This demonstrates the PTPRN antibody detected the PTPRN protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Maus Ziege Unkonjugiert ELISA, WB Western Blot: IA-2/PTPRN Antibody [NBP1-00134] - Analysis of PTPRN in NIH 3T3 lysate (35ug protein in RIPA buffer) using this antibody at 0.5 ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$485.88
Details
Rind (Kuh) Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry: IA-2/PTPRN Antibody [NBP1-83128] - Immunohistochemical staining of human pancreas shows strong cytoplasmic positivity in islet cells. Immunohistochemistry-Paraffin: IA-2/PTPRN Antibody  - Staining of adrenal gland shows strong cytoplasmic positivity in medullary cells. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 50 μg Anmelden zum Anzeigen 6 bis 8 Tage
$412.50
Details
Maus Ziege Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 10 bis 12 Tage
$455.40
Details
Maus Ziege Unkonjugiert ELISA, WB 0.1 mg Anmelden zum Anzeigen 2 bis 3 Tage
$481.25
Details
Human Kaninchen Unkonjugiert WB Western Blot: IA-2/PTPRN Antibody [NBP1-59411] - HepG2 cell lysate, concentration 0.0625ug/ml. Western Blot: IA-2/PTPRN Antibody [NBP1-59411] - Human Kidney, Antibody Dilution: 0.5 ug/ml. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details

PTPRN Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-PTPRN Antikörper

  1. Human Polyclonal PTPRN Primary Antibody für IHC, IHC (p) - ABIN4320764 : Lindskog, Korsgren, Pontén, Eriksson, Johansson, Danielsson: Novel pancreatic beta cell-specific proteins: antibody-based proteomics for identification of new biomarker candidates. in Journal of proteomics 2012 (PubMed)

  2. Mouse (Murine) Polyclonal PTPRN Primary Antibody für ELISA, WB - ABIN314237 : Buzzetti, Di Pietro, Giaccari, Petrone, Locatelli, Suraci, Capizzi, Arpi, Bazzigaluppi, Dotta, Bosi: High titer of autoantibodies to GAD identifies a specific phenotype of adult-onset autoimmune diabetes. in Diabetes Care 2007 (PubMed)

Weitere Antikörper gegen PTPRN Interaktionspartner

Human Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) Interaktionspartner

  1. E. coli GI724 strain emerged as a handy source of recombinant IA-2ic, achieving high levels of expression as a thioredoxin (zeige TXN Antikörper) fusion protein, adequately validated and applicable to the development of innovative and cost-effective immunoassays for IA-2A detection in most laboratories.

  2. Identification of amino acids contributing to distinct epitopes on IA-2, with both HLA-DR and HLA-DQ alleles influencing epitope specificity.

  3. RESP18HD is required for efficient sorting of ICA512 to secretory granules: RESP18HD is a key determinant for ICA512 granule targeting.

  4. The binding of CREB (zeige CREB1 Antikörper) to the promoter region, -216 to +115, enhanced IA-2 transcription by more than fivefold.

  5. Kaplan-Meier survival curves estimated a worst pancreas graft survival for patients with positive IA-2 antibodies versus those patients with negative auto-antibodies and GAD65 (zeige GAD2 Antikörper)+ auto-antibodies after simultaneous pancreas kidney transplantation.

  6. Humoral responses to islet antigen-2 and zinc transporter 8 are attenuated in patients carrying HLA-A*24 alleles at the onset of type 1 diabetes.

  7. Letter: report lack of anti-IA2 autoantibodies in primary antiphospholipid syndrome.

  8. analysis of protein-protein interactions in crystals of the human receptor-type protein tyrosine phosphatase (zeige ACP1 Antikörper) ICA512 ectodomain

  9. In families with type 1 diabetes, there was a female predominance and more family history of associated autoimmune diseases (AAIDs) in the group with AAIDs, and less frequent anti-IA-2 antibodies

  10. Longer survival was associated with hypomethylation at specific CpG sites (e.g. GREB1 (zeige GREB1 Antikörper), TGIF (zeige IL10 Antikörper) and TOB1) and hypermethylation in other genes (e.g. TMCO5, PTPRN and GUCY2C (zeige GUCY2C Antikörper)).

Mouse (Murine) Protein Tyrosine Phosphatase, Receptor Type, N (PTPRN) Interaktionspartner

  1. The deletion of IA-2 and IA-2beta (zeige PTPRN2 Antikörper) results in multiple pathophysiologic changes and represents a unique in vivo model for studying the effect of hormone and neurotransmitter reduction on known and still unrecognized targets.

  2. Ptprn is an activity dependent gene in mouse olfactory sensory neurons. [Ptprn]

  3. Data show that miRNAs are involved in regulating the expression of the major type 1 diabetes (T1D) autoantigens IA-2, IA-2beta (zeige PTPRN2 Antikörper), and GAD65 (zeige GAD2 Antikörper) enzyme.

  4. Experiments showed that the knock-out of IA-2, but not IA-2beta (zeige PTPRN2 Antikörper), resulted in marked impairment of active avoidance learning; one copy of the gene was sufficient to maintain active avoidance learning

  5. Data show that the insulinoma associated protein-2 (zeige INSM2 Antikörper) distribution in peripheral neurons appeared more intensely in neurites rather than in the cell bodies.

  6. IA-2-/- mice had higher sensitivity to STZ, suggesting a role of IA-2 not only in the secretion but also in the production of insulin (zeige INS Antikörper).

  7. IA-2 is involved in glucose-stimulated insulin (zeige INS Antikörper) secretion

  8. experiments show that the dense core vesicle proteins IA-2 and IA-2beta (zeige PTPRN2 Antikörper), alone or in combination, are involved in insulin (zeige INS Antikörper) secretion, but neither alone nor in combination are they required for the development of diabetes in NOD mice

  9. IA-2beta (zeige PTPRN2 Antikörper), but not IA-2, is induced by ghrelin (zeige GHRL Antikörper) and inhibits glucose-stimulated insulin (zeige INS Antikörper) secretion

  10. The cleaved cytosolic fragment of ICA512 enhances the transcription of secretory granule genes (including its own gene) by binding to tyrosine phosphorylated signal transducers and activators of transcription (STAT) 5 (zeige STAT5A Antikörper) and preventing its dephosphorylation.

PTPRN Antigen-Profil

Protein Überblick

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit PTPRN

  • protein tyrosine phosphatase, receptor type N (PTPRN) Antikörper
  • protein tyrosine phosphatase, receptor type, N (Ptprn) Antikörper
  • protein tyrosine phosphatase, receptor type N (Ptprn) Antikörper
  • Ia-2 Antikörper
  • IA-2/PTP Antikörper
  • IA2 Antikörper
  • ICA512 Antikörper
  • mIA-A Antikörper
  • mKIAA4064 Antikörper
  • R-PTP-N Antikörper

Bezeichner auf Proteinebene für PTPRN

ICA 512 , PTP IA-2 , islet cell antigen 2 , islet cell antigen 512 , islet cell autoantigen 3 , protein tyrosine phosphatase-like N , receptor-type tyrosine-protein phosphatase-like N , ICA512 , R-PTP-N , islet cell autoantigen 512 , protein tyrosine phosphatase, receptor-type, N , 105 kDa islet cell antigen , BEM-3 , ICA105 , PTPLP , brain-enriched membrane-associated protein tyrosine phosphatase , insulinoma antigen-2 , receptor type N protein tyrosine phosphatase

GENE ID SPEZIES
5798 Homo sapiens
286810 Bos taurus
19275 Mus musculus
116660 Rattus norvegicus
100355368 Oryctolagus cuniculus
100733759 Cavia porcellus
100155609 Sus scrofa
478921 Canis lupus familiaris
101113312 Ovis aries
Ausgewählte Anbieter für anti-PTPRN (PTPRN) Antikörper
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