IA-2 antikoerper, IA-2/PTP antikoerper, IA2 antikoerper, ICA512 antikoerper, R-PTP-N antikoerper, mIA-A antikoerper, mKIAA4064 antikoerper, Ia-2 antikoerper, fc43c04 antikoerper, ptprn antikoerper, wu:fc43c04 antikoerper, ia-2 antikoerper, ia2 antikoerper, ica512 antikoerper, r-ptp-n antikoerper, protein tyrosine phosphatase, receptor type N antikoerper, protein tyrosine phosphatase, receptor type, N antikoerper, protein tyrosine phosphatase, receptor type, Na antikoerper, protein tyrosine phosphatase, receptor type N L homeolog antikoerper, PTPRN antikoerper, Ptprn antikoerper, ptprna antikoerper, ptprn.L antikoerper
Hintergrund
IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family,which contains a transmembrane region,an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.