anti-Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Antikörper

ZAK is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). Zusätzlich bieten wir Ihnen ZAK Proteine (9) und ZAK Kits (3) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
ZAK 311743  
ZAK 51776 Q9NYL2
ZAK 65964 Q9ESL4
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Top anti-ZAK Antikörper auf antikoerper-online.de

Showing 10 out of 70 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-MLKLAK-C284 Pab (ABIN392643) in HepG2 cell line lysate (35 µg/lane). MLKLAK-C284(arrow) was detected using the purified polyclonal antibody (1:60 dilution). This western blot detected isoform 2 of MLKLAK, the accession number for MLKLAK isoform 1 is Q9NYL2, NP_057737. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
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Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Kaninchen Unkonjugiert IF, ELISA, WB Western blot analysis of extracts from HeLa cells, using MLTK Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HepG2 cells, using MLTK Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from Jurkat cells, using ZAK (Ab-165) Antibody. The lane on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Maus Unkonjugiert IF Immunofluorescence of to ZAK on HeLa cell . Detection limit for recombinant GST tagged ZAK is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: ZAK Antibody  - Analysis in human cell line U-138 MG. Immunocytochemistry/Immunofluorescence: ZAK Antibody  - Immunofluorescent staining of human cell line A-431 shows localization to cytosol. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$439.69
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Human Kaninchen Unkonjugiert ELISA, IF, WB 100 μL Anmelden zum Anzeigen 16 Days
$175.80
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Human Kaninchen Unkonjugiert WB WB Image Sample (30 ug of whole cell lysate) A: A549 7.5% SDS PAGE antibody diluted at 1:1000 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details
Human Maus Unkonjugiert IF, IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to ZAK on formalin-fixed paraffin-embedded human prostate. [antibody concentration 3 ug/ml] ZAK monoclonal antibody (M03), clone 3G5. Western Blot analysis of ZAK expression in human stomach. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$430.00
Details
Human Kaninchen Unkonjugiert IC, IF, WB Immunofluorescent analysis of ZAK staining in HeLa cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody in 3% BSA-PBS and incubated overnight at 4 °C in a humidified chamber. Cells were washed with PBST and incubated with a DyLight 594-conjugated secondary antibody (red) in PBS at room temperature in the dark. DAPI was used to stain the cell nuclei (blue). Western blot analysis of ZAK expression in HeLa (A), HepG2 (B), NIH3T3 (C) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
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ZAK Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-ZAK Antikörper

  1. Human Monoclonal ZAK Primary Antibody für IF, IHC (p) - ABIN565679 : Cariolato, Cavin, Diviani: A-kinase anchoring protein (AKAP)-Lbc anchors a PKN-based signaling complex involved in ?1-adrenergic receptor-induced p38 activation. in The Journal of biological chemistry 2011 (PubMed)
    Show all 3 Pubmed References

  2. Human Polyclonal ZAK Primary Antibody für ICC, IF - ABIN4366552 : Liu, McCleland, Stawiski, Gnad, Mayba, Haverty, Durinck, Chen, Klijn, Jhunjhunwala, Lawrence, Liu, Wan, Chopra, Yaylaoglu, Yuan, Ha, Gilbert, Reeder, Pau, Stinson, Stern, Manning, Wu, Neve et al.: Integrated exome and transcriptome sequencing reveals ZAK isoform usage in gastric cancer. ... in Nature communications 2014 (PubMed)

Weitere Antikörper gegen ZAK Interaktionspartner

Human Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Interaktionspartner

  1. Gene set enrichment analysis disclosed a significant correlation between ZAK+ colorectal premalignant lesions and gene sets belonging to the MAPK/ERK (zeige MAPK1 Antikörper) and motility-related signaling pathways of the reactome database, strongly suggesting that ZAK induces such pro-tumoral reaction cascades in human cancers.

  2. Recessive mutations in the kinase ZAK - novel cause of congenital myopathy.

  3. ZAK is a key player in mammalian limb patterning in humans and mice.

  4. ZAK kinase isoform TV1 is preferentially upregulated in gastric tumours and cell lines relative to normal samples. This pattern is also observed in colorectal, bladder and breast cancers.

  5. The long non-coding RNA URHC promotes cell proliferation and inhibits apoptosis by repressing ZAK expression through inactivation of the ERK/MAPK (zeige MAPK1 Antikörper) pathway.

  6. we report that sorafenib suppresses UV-induced apoptosis specifically by inhibiting c-jun (zeige JUN Antikörper)-NH(2)-kinase (JNK (zeige MAPK8 Antikörper)) activation through the off-target inhibition of leucine zipper and sterile alpha motif-containing kinase (ZAK)

  7. MRK (zeige ICK Antikörper) is a novel RhoC (zeige RHOC Antikörper) effector that controls LPA (zeige APOA Antikörper)-stimulated cell invasion at least in part by regulating myosin dynamics, ERK (zeige EPHB2 Antikörper) and p38 (zeige CRK Antikörper)

  8. The genes identified KTN1 (zeige KTN1 Antikörper), ROCK1 (zeige ROCK1 Antikörper), and ZAK may be responsible for loss of cellular homeostasis in giant cells tumors of bone

  9. decrease of lung cancer cell proliferation by ZAK may involve the ERK (zeige EPHB2 Antikörper) and JNK (zeige MAPK8 Antikörper) pathways via an AP-1 (zeige FOSB Antikörper) transcription factor.

  10. In this study, by applying a novel method, we have identified the phosphorylation sites in human MSK1 mitogen- and stress-activated protein kinase 1 (zeige RPS6KA5 Antikörper), and show that MRK (zeige ICK Antikörper)-beta could also activate MSK1 (zeige RPS6KA5 Antikörper) through direct interaction.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase MLT (ZAK) Interaktionspartner

  1. Zak-/- mice demonstrate a distinct ribotoxic stress-associated phenotype in response to ricin.

  2. ZAK is a key player in mammalian limb patterning in humans and mice.

  3. Exome sequencing analysis between SM/J and A/J mice identified 4 genes (Itga6 (zeige ITGA6 Antikörper), Zak, Gpr155, and Mtx2 (zeige MTX2 Antikörper)) with nonsynonymous coding SNPs. These four genes might be candidate genes for type 2 diabetes caused by gene-gene interactions.

  4. PKNalpha (zeige PKN1 Antikörper) functions as not only an upstream activator of MLTKalpha but also a putative scaffold protein (zeige HOMER1 Antikörper) for the p38gamma (zeige MAPK12 Antikörper) MAPK (zeige MAPK1 Antikörper) signaling pathway

  5. Results show that mixed lineage kinase-like mitogen-activated protein triple kinase (MLTK_-alpha plays a key role in the UVB- and EGF (zeige EGF Antikörper)-induced phosphorylation of histone H3 (zeige HIST3H3 Antikörper) at Ser28.

  6. Mixed lineage kinase (zeige MAP3K12 Antikörper) 7 (MLK7), a splice variant of the human ZAK gene (ortholog of mouse B230120H23Rik), encodes an isoform which is the MAPKKK required for modulation of the stress-activated MAPKs downstream of anisomycin and UV stimulation.

ZAK Antigen-Profil

Protein Überblick

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Genbezeichner und Symbole assoziert mit ZAK

  • mitogen-activated protein kinase kinase kinase 20 (Map3k20) Antikörper
  • mitogen-activated protein kinase kinase kinase 20 (MAP3K20) Antikörper
  • AV006891 Antikörper
  • AZK Antikörper
  • B230120H23Rik Antikörper
  • MLK7 Antikörper
  • mlklak Antikörper
  • MLT Antikörper
  • MLTK Antikörper
  • MLTKalpha Antikörper
  • MLTKbeta Antikörper
  • MRK Antikörper
  • pk Antikörper
  • RGD1561394 Antikörper

Bezeichner auf Proteinebene für ZAK

mitogen-activated protein kinase kinase kinase MLT , HCCS-4 , MLK-like mitogen-activated protein triple kinase , human cervical cancer suppressor gene 4 protein , mixed lineage kinase 7 , mixed lineage kinase with a leucine zipper and a sterile alpha motif , mixed lineage kinase-related kinase MRK-beta , MLK-related kinase , MRK , leucine zipper- and sterile alpha motif kinase ZAK , mixed lineage kinase-related kinase , sterile alpha motif- and leucine zipper-containing kinase AZK , sterile-alpha motif and leucine zipper containing kinase AZK

GENE ID SPEZIES
311743 Rattus norvegicus
51776 Homo sapiens
65964 Mus musculus
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