anti-Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Antikörper

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. Zusätzlich bieten wir Ihnen IDH2 Proteine (20) und IDH2 Kits (14) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
IDH2 3418 P48735
IDH2 269951 P54071
IDH2 361596 P56574
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Top anti-IDH2 Antikörper auf antikoerper-online.de

Showing 10 out of 113 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB <b>WB Suggested Anti-IDH2 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:12500<br><b>Positive Control: </b>Human Muscle 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Rat Intestine Tissue Anti- IDH2 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$280.00
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon (antibody concentration 3 µg/mL).  Detection limit for recombinant GST tagged IDH2 is approximately 0.03 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert WB Western Blot: IDH2 Antibody [NBP1-54779] - Titration: 0.2-1 ug/ml, Positive Control: Human Muscle. Western Blot: IDH2 Antibody [NBP1-54779] - Middle region validated by WB using Proximal kidney tubules purfied from cortex at 1:1000. 100 μL Anmelden zum Anzeigen 8 bis 11 Tage
$485.88
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP1-85784] - Staining of human cell line U-2 OS shows positivity in mitochondria. Western Blot: IDH2 Antibody [NBP1-85784] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11.Lane 2: Human cell line RT-4.Lane 3: Human cell line U-251MG sp 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunocytochemistry/Immunofluorescence: IDH2 Antibody [NBP2-22166] - IDH2 antibody was tested in U2OS cells with DyLight (green). Nuclei and alpha-tubulin were counterstained with DAPI (blue) and Dylight 550 (red). Western Blot: IDH2 Antibody [NBP2-22166] - Western blot analysis of Caki-1 cell lysate (A), human skeletal muscle tissue (B), mouse skeletal muscle tissue (C), and rat skeletal muscle tissue (D) using IDH2 antibody at a concentration of 2 ug/ml. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$415.44
Details
Fledermaus Kaninchen Unkonjugiert WB 50 μg Anmelden zum Anzeigen 7 bis 9 Tage
$551.83
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB Immunoperoxidase of monoclonal antibody to IDH2 on formalin-fixed paraffin-embedded human colon. [antibody concentration 3 ug/ml] Detection limit for recombinant GST tagged IDH2 is approximately 0.03ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert IF (p), IHC (p), WB Formalin-fixed and paraffin embedded human lung carcinoma labeled with Rabbit Anti IDH2 Polyclonal Antibody, Unconjugated (ABIN751558) at 1:200 followed by conjugation to the secondary antibody and DAB staining Formalin-fixed and paraffin-embedded lung carcinoma labeled with Anti-IDH2 Polyclonal Antibody, Unconjugated (ABIN751558) 1:200, overnight at 4°C, The secondary antibody was Goat Anti-Rabbit IgG, Cy3 conjugated used at 1:200 dilution for 40 minutes at 37°C. 100 μL Anmelden zum Anzeigen 3 bis 7 Tage
$306.90
Details
Human Kaninchen Unkonjugiert EIA, WB   0.1 mg Anmelden zum Anzeigen 12 bis 15 Tage
$469.32
Details

IDH2 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-IDH2 Antikörper

  1. Human Polyclonal IDH2 Primary Antibody für ICC, IF - ABIN4321024 : Saha, Gordan, Kleinstiver, Vu, Najem, Yeo, Shi, Kato, Levin, Webber, Damon, Egan, Greninger, McDermott, Garnett, Jenkins, Rieger-Christ, Sullivan, Hezel, Liss, Mizukami, Goyal, Ferrone, Zhu, Joung et al.: Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ... in Cancer discovery 2016 (PubMed)
    Show all 2 Pubmed References

  2. Human Monoclonal IDH2 Primary Antibody für IHC (p), ELISA - ABIN561418 : Gambichler, Terras, Kreuter, Skrygan: Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms. in The British journal of dermatology 2014 (PubMed)

  3. Human Polyclonal IDH2 Primary Antibody für ICC, IF - ABIN4321022 : Murgia, Nagaraj, Deshmukh, Zeiler, Cancellara, Moretti, Reggiani, Schiaffino, Mann: Single muscle fiber proteomics reveals unexpected mitochondrial specialization. in EMBO reports 2015 (PubMed)

  4. Human Polyclonal IDH2 Primary Antibody für ELISA, WB - ABIN4321020 : Abbas, Lugthart, Kavelaars, Schelen, Koenders, Zeilemaker, van Putten, Rijneveld, Löwenberg, Valk: Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value. in Blood 2010 (PubMed)

  5. Cow (Bovine) Polyclonal IDH2 Primary Antibody für WB - ABIN2783282 : Shin, Kil, Park: Silencing of mitochondrial NADP+-dependent isocitrate dehydrogenase by small interfering RNA enhances heat shock-induced apoptosis. in Biochemical and biophysical research communications 2008 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen IDH2 Interaktionspartner

Arabidopsis thaliana Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Leaf IDH activity reduced by 43% in mutant

Human Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. IDH1/2 mutations induce a homologous recombination defect that renders tumor cells exquisitely sensitive to poly(adenosine 5'-diphosphate-ribose) polymerase inhibitors

  2. To confirm this result, we analyzed survival data from 142 LGGs from TCGA with IDH1 (zeige IDH1 Antikörper)/IDH2 mutations and no 1p19q codeletion. Despite the high rate of censured data, we found that CNLOH 17p, including the TP53 (zeige TP53 Antikörper) locus, was associated with better outcome (OR = 0.27; p = .026)

  3. 6 cases of diffuse glioma that presented a diagnostic challenge due to conflicting IDH1 (zeige IDH1 Antikörper)/IDH2, ATRX (zeige ATRX Antikörper), and 1p/19q results.

  4. In this review, we focus on three key areas in acute myeloid leukemia (zeige BCL11A Antikörper) (AML (zeige RUNX1 Antikörper)) developmental therapeutics: FLT3 (zeige FLT3 Antikörper) inhibitors, IDH(IDH1 (zeige IDH1 Antikörper) and IDH2 ) inhibitors, and drugs that may be particularly beneficial in secondary AML (zeige RUNX1 Antikörper)

  5. The role of mutant IDH1 (zeige IDH1 Antikörper) and IDH2 inhibitors in the treatment of acute myeloid leukemia (zeige BCL11A Antikörper).

  6. olaparib and other PARP (zeige COL11A2 Antikörper) inhibitors killed cells in multiple cancer cell lines that harbor IDH1 (zeige IDH1 Antikörper) and IDH2 mutations. In addition, glioma cell lines generated from patient tumors with IDH1 (zeige IDH1 Antikörper) mutations were vulnerable to the investigational PARP (zeige COL11A2 Antikörper) inhibitor talazoparib . In mice, olaparib slowed the growth of implanted IDH1 (zeige IDH1 Antikörper)-mutant tumors.

  7. demonstrate the presence of the IDH2 p.R172K/S mutation in patients with cutaneous localizations of angioimmunoblastic T-cell lymphomas.

  8. an IDH mutant-enriched subtype of cholangiocarcinoma with distinct molecular features including low expression of chromatin modifiers, elevated expression of mitochondrial genes, and increased mitochondrial DNA copy number, is reported.

  9. IDH (zeige IDH1 Antikörper) mutations define a distinct subtype of ICC, a malignancy that is largely refractory to current therapies. Our work demonstrates that IDHm ICC cells are hypersensitive to dasatinib and critically dependent on SRC (zeige SRC Antikörper) activity for survival and proliferation, pointing to new therapeutic strategies against these cancers.

  10. Mutations in the IDH1 (zeige IDH1 Antikörper) and IDH2 genes perturb the epigenome through cytosine methylation, histone post-translational modifications and transcription factors. [review]

Mouse (Murine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Increased obesity resistance and insulin (zeige INS Antikörper) sensitivity in mice lacking the IDH2 gene has been documented.

  2. treatment with Mito-TEMPO, a mitochondrial-specific superoxide scavenger, recovered mitochondrial fission-fusion imbalance and blunted mitochondrial superoxide production, and reduced the IDH2 knockdown-induced decrease in MnSOD (zeige SOD2 Antikörper) expression, eNOS (zeige NOS3 Antikörper) phosphorylation and NO production in endothelial cells

  3. Findings demonstrate that IDH2 contributes to degeneration of the DA neuron in the neurotoxin model of Parkinson's Disease.

  4. IDH2 deficiency promotes mitochondrial dysfunction and cardiac hypertrophy in mice.

  5. IDH2 and NPM1 (zeige GJA1 Antikörper) mutations synergize in the development and maintenance of acute myeloid leukemia (zeige BCL11A Antikörper) stem-like cells.

  6. 7-Ketocholesterol inhibits isocitrate dehydrogenase 2 expression and impairs endothelial function via microRNA-144 leading to atherosclerosis.

  7. These data demonstrate the proto-oncogenic role of mutant IDH2.

  8. The tumor tissue of B16F10 cells transfected with IDH2 antisense cDNA exhibited induction of apoptosis and downregulation of angiogenesis markers.

  9. Data indicate that tumor tissues from idh2-/- ((knock-out) mice had significantly decreased HIF-1alpha (zeige HIF1A Antikörper) expression, blunted mRNA expression of HIF-1alpha (zeige HIF1A Antikörper), VEGF (zeige VEGFA Antikörper), and the glucose transport protein Glut-1 (zeige SLC1A3 Antikörper) was also observed.

  10. IDH2 mutants can cooperate with oncogenic Flt3 (zeige FLT3 Antikörper) or Nras (zeige NRAS Antikörper) alleles to drive leukemia in mice by impairing the differentiation of cells of the myeloid lineage

Cow (Bovine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. The enzyme is highly sensitive to Mg(2 (zeige MCOLN1 Antikörper)+) concentration in the physiological range, pointing to a potential regulatory role of [Mg(2 (zeige MCOLN1 Antikörper)+)] in mitochondrial energy metabolism.

Pig (Porcine) Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2) Interaktionspartner

  1. Tyr140 and Lys212 are required for the catalytic activity of porcine NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)

  2. analysis of the coenzyme binding site in the porcine mitochondrial NADP-dependent isocitrate dehydrogenase (zeige IDH3B Antikörper)

  3. These results suggest that IDPm plays an important protective role in cadmium-induced apoptosis by maintaining cellular redox status and by protection of Grx (zeige GRX1 Antikörper) activity.

IDH2 Antigen-Profil

Protein Überblick

Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex.

Genbezeichner und Symbole assoziert mit IDH2

  • isocitrate dehydrogenase subunit 2 (IDH2) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2) Antikörper
  • isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S) Antikörper
  • isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2) Antikörper
  • isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867) Antikörper
  • D2HGA2 Antikörper
  • E430004F23 Antikörper
  • F6P23.14 Antikörper
  • F6P23_14 Antikörper
  • ICD-M Antikörper
  • IDH Antikörper
  • Idh-2 Antikörper
  • IDH-II Antikörper
  • IDH2 Antikörper
  • IDHM Antikörper
  • IDP Antikörper
  • IDPm Antikörper
  • isocitrate dehydrogenase II Antikörper
  • isocitrate dehydrogenase subunit 2 Antikörper
  • mNADP-IDH Antikörper
  • NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2 Antikörper
  • wu:fb33c06 Antikörper
  • wu:fk31e05 Antikörper
  • wu:fq43b01 Antikörper
  • zgc:55485 Antikörper

Bezeichner auf Proteinebene für IDH2

NADP(+)-specific ICDH , isocitrate dehydrogenase [NADP], mitochondrial , oxalosuccinate decarboxylase , ICD-M , IDH , IDP , NADP+-specific isocitrate dehydrogenase , NADPH-specific isocitrate dehydrogenase , isocitrate dehydrogenase 2 (NADP+), mitochondrial , isocitrate dehydrogenase [NADP], mitochondrial-like

GENE ID SPEZIES
816218 Arabidopsis thaliana
3418 Homo sapiens
269951 Mus musculus
327669 Bos taurus
361596 Rattus norvegicus
380013 Xenopus laevis
386951 Danio rerio
397603 Sus scrofa
448026 Xenopus (Silurana) tropicalis
453645 Pan troglodytes
479043 Canis lupus familiaris
701480 Macaca mulatta
100441867 Pongo abelii
431056 Gallus gallus
100726681 Cavia porcellus
100340796 Oryctolagus cuniculus
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