IDH2 Produkte
(Isocitrate Dehydrogenase 2 (NADP+), Mitochondrial (IDH2))
Kategorien
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the mitochondria. It plays a role in intermediary metabolism and energy production. This protein may tightly associate or interact with the pyruvate dehydrogenase complex. [provided by RefSeq, Jul 2008].
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Ausgewählte IDH2 Kategorien
IDH2 Antikörper
High quality antibodies with extensive validation data.
IDH2 ELISA Kits
Reliable ELISA kits for a wide range of species.
IDH2 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene IDH2 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC (p), IHC (fro), ICC
Validierungen
- (7)
Kat. Nr.
ABIN7441520
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, ELISA, IHC, FACS, ICC, Neut
Validierungen
- (6)
Kat. Nr.
ABIN7193379
Menge
0.1 mg
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IP, IF, ChIP
Validierungen
- (1)
- (5)
Kat. Nr.
ABIN6142146
Menge
100 μL
Datenblatt
Datenblatt
Empfohlene IDH2 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Analytical Method
Quantitative Sandwich ELISA
Validierungen
- (1)
- (1)
Kat. Nr.
ABIN6957224
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human
Analytical Method
Validierungen
Kat. Nr.
ABIN1138941
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Mouse
Analytical Method
Validierungen
Kat. Nr.
ABIN1138942
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene IDH2 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307372
Menge
10 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1307371
Menge
25 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Insect Cells
Validierungen
- (1)
Kat. Nr.
ABIN3081813
Menge
1 mg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren IDH2 Produkten
: "IDH2 is a novel diagnostic and prognostic serum biomarker for non-small-cell lung cancer." in: Molecular oncology, Vol. 12, Issue 5, pp. 602-610, (2019) (PubMed).: "Isocitrate Dehydrogenase Mutations Confer Dasatinib Hypersensitivity and SRC Dependence in Intrahepatic Cholangiocarcinoma. ..." in: Cancer discovery, Vol. 6, Issue 7, pp. 727-39, (2016) (PubMed).
: "Identification of proteins responsible for adriamycin resistance in breast cancer cells using proteomics analysis." in: Scientific reports, Vol. 5, pp. 9301, (2016) (PubMed).
: "Single muscle fiber proteomics reveals unexpected mitochondrial specialization." in: EMBO reports, Vol. 16, Issue 3, pp. 387-95, (2015) (PubMed).
: "Reductive carboxylation and 2-hydroxyglutarate formation by wild-type IDH2 in breast carcinoma cells." in: The international journal of biochemistry & cell biology, Vol. 65, pp. 125-33, (2015) (PubMed).
: "Altered global methylation and hydroxymethylation status in vulvar lichen sclerosus: further support for epigenetic mechanisms." in: The British journal of dermatology, Vol. 170, Issue 3, pp. 687-93, (2014) (PubMed).
: "Mutant IDH inhibits HNF-4α to block hepatocyte differentiation and promote biliary cancer. ..." in: Nature, Vol. 513, Issue 7516, pp. 110-4, (2014) (PubMed).
: "D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neurodegeneration in mice. ..." in: Genes & development, Vol. 28, Issue 5, pp. 479-90, (2014) (PubMed).
: "Elevated CO(2) levels cause mitochondrial dysfunction and impair cell proliferation." in: The Journal of biological chemistry, Vol. 286, Issue 43, pp. 37067-76, (2011) (PubMed).
: "Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value." in: Blood, Vol. 116, Issue 12, pp. 2122-6, (2010) (PubMed).
Synonyme und alternative Namen zu IDH2
isocitrate dehydrogenase subunit 2 (IDH2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (IDH2), isocitrate dehydrogenase 2 (NADP+), mitochondrial (Idh2), isocitrate dehydrogenase (NADP(+)) 2, mitochondrial (Idh2), isocitrate dehydrogenase 2 (NADP+), mitochondrial S homeolog (idh2.S), isocitrate dehydrogenase 2 (NADP+), mitochondrial (idh2), isocitrate dehydrogenase [NADP], mitochondrial (LOC100441867), D2HGA2, E430004F23, F6P23.14, F6P23_14, ICD-M, IDH, Idh-2, IDH-II, idh2, IDH2, IDHM, IDP, IDPM, IDPm, isocitrate dehydrogenase II, isocitrate dehydrogenase subunit 2, mNADP-IDH, NAD+ DEPENDENT ISOCITRATE DEHYDROGENASE SUBUNIT 2, wu:fb33c06, wu:fk31e05, wu:fq43b01, zgc:55485Bezeichner auf Proteinebene für IDH2
- NADP(+)-specific ICDH
- isocitrate dehydrogenase [NADP], mitochondrial
- oxalosuccinate decarboxylase
- ICD-M
- IDH
- IDP
- NADP+-specific isocitrate dehydrogenase
- NADPH-specific isocitrate dehydrogenase
- isocitrate dehydrogenase 2 (NADP+), mitochondrial
- isocitrate dehydrogenase [NADP], mitochondrial-like
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