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HNRNPA2B1 belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). Zusätzlich bieten wir Ihnen HNRNPA2B1 Antikörper (133) und HNRNPA2B1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human HNRNPA2B1 ELISA Kit für Sandwich ELISA - ABIN416755
Dowling, Pollard, Larkin, Henry, Meleady, Gately, OByrne, Barr, Lynch, Ballot, Crown, Moriarty, OBrien, Morgan, Clynes: Abnormal levels of heterogeneous nuclear ribonucleoprotein A2B1 (hnRNPA2B1) in tumour tissue and blood samples from patients diagnosed with lung cancer. in Molecular bioSystems 2014
High HNRNPA2B1 expression is associated with cervical cancer.
m6A switches may account for the previously seen enhanced hnRNP A2/B1 binding adjacent to m6A; instead of direct binding to m6A, m6A may promote accessibility of hnRNP A2/B1 to certain binding sites, thereby explaining how m6A can facilitate the ability of hnRNP A2/B1 to enhance nuclear events such as pri-miRNA processing
revealed a novel heterozygous missense mutation of hnRNPA2B1 gene (c.929C>T, p. P310L) in the two patients which was then verified in all affected individuals
Cilostazol pretreatment can reduce the excessive expression of inflammatory cytokines and chemokines and hnRNP A2/B1 by the Behcet's disease-related stimulants.
UCP2 stimulates hnRNPA2/B1, GLUT1 and PKM2 expression and sensitizes pancreatic cancer cells to glycolysis inhibition.
We demonstrate that the wild-type sequence harbors an hnRNP A1 (zeige HNRNPA1 ELISA Kits) and hnRNP A2/B1-binding exonic splicing silencer (ESS) overlapping the 5'splice site (5'ss) that prevents pseudoexon inclusion.we demonstrate that splice switching oligonucleotide (SSO) mediated blocking of the pseudoexon 3'ss and 5'ss effectively restores normal GLA splicing
Data suggest that galectin-3 (zeige LGALS3 ELISA Kits) and heterogeneous ribonucleoprotein (zeige RBP31 ELISA Kits) particle component hnRNPA2B1 interact as members of the early splicing machinery.
effect of mutations on the aggregation propensity of hnRNPA2
ALS-associated hnRNPA2B1 D290V mutant patient fibroblasts and motor neurons differentiated from iPSCs (iPSC-MNs) demonstra (zeige IGFALS ELISA Kits)te abnormal splicing changes, likely d (zeige DAO ELISA Kits)ue to increased nuclear-insoluble hnRNPA2B1. Mutant iPSC-MNs display decreased survival in long-term culture and exhibit hnRNPA2B1 localization to cytoplasmic granules as well as exacerbated changes in gene expression and splicing upon cellular stress.
Motor-neuron disease (MND)-linked RNA-binding proteins (RBPs), TDP-43 (zeige TARDBP ELISA Kits), FUS (zeige FUS ELISA Kits), and hnRNPA2B1, bind to and induce structural alteration of UGGAAexp. These RBPs suppress UGGAAexp-mediated toxicity in Drosophila by functioning as RNA chaperones for proper UGGAAexp folding and regulation of pentapeptide repeat translation.
HnRNP A2/B1 loss results in alternative splicing (AS), including skipping of an exon in amyotrophic lateral sclerosis (ALS)-associated D-amino acid oxidase (DAO (zeige DAO ELISA Kits)) that reduces D-serine metabolism.
Findings suggest that hnRNP A2/B1 has an important role in regulation of the innate immune system, especially at the level of monocyte/macrophage activation.
hnRNPA2/B1 plays a functional role in SMC differentiation from stem cells in vitro and embryonic branchial arch artery development.
splicing repressors hnRNP A1 and A2, as well as the polypyrimidine-tract-binding protein PTB, contribute to control of pyruvate kinase isoform M1 and M2 expression
overproduction of TNF-alpha leads to aberrant expression of hnRNP-A2 in the rheumatoid joint and subsequently to autoimmune reactions, which may enhance the inflammatory and destructive process.
These results are consistent with a model where hnRNP E1 recruited to A2RE RNA granules by binding to hnRNP A2 inhibits translation of A2RE RNA during granule transport.
Active Fyn (zeige FYN ELISA Kits) phosphorylates hnRNP A2 and stimulates translation of an myelin basic protein (MBP (zeige MBP ELISA Kits)) A2RE (A2 response element) -containing reporter construct.
A common mechanism of mitochondrial respiratory stress-induced activation of nuclear target genes that involves hnRNP A2 as a transcription coactivator, is described.
This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms.
heterogeneous nuclear ribonucleoproteins A2/B1
, hnRNP A2 / hnRNP B1
, nuclear ribonucleoprotein particle A2 protein
, heterogeneous nuclear ribonucleoprotein A2/B1
, Heterogeneous nuclear ribonucleoprotein A2 homolog 1
, heterogenous nuclear ribonucleoprotein A2/B1
, hnRNP A2/B1
, heterogeneous nuclear ribonucleoprotein A2
, heterogeneous nuclear ribonucleoprotein B0a
, heterogeneous nuclear ribonucleoprotein B0b
, heterogeneous nuclear ribonucleoprotein B1