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GCET2 encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. Zusätzlich bieten wir Ihnen Germinal Center Expressed Transcript 2 Antikörper (40) und Germinal Center Expressed Transcript 2 Kits (3) und viele weitere Produktgruppen zu diesem Protein an.
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Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts.
Diagnostic Utility of the Germinal Center-associated Markers GCET1 (zeige SERPINA9 Proteine), HGAL, and LMO2 (zeige LMO2 Proteine) in Hematolymphoid Neoplasms.
These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes.
HGAL and LMO2 (zeige LMO2 Proteine) may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract.
the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B (zeige TDO2 Proteine)-cell lymphoproliferation (zeige FAS Proteine).
HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma.
Immunostaining for HGAL was more frequently positive than that for BCL6 (zeige BCL6 Proteine) and CD10 (zeige MME Proteine) in follicular lymphomas
Data suggest that both HGAL and LMO2 (zeige LMO2 Proteine) are directly regulated by the transcription repressor PRDM1 (zeige PRDM1 Proteine)--overexpression of PRDM1 (zeige PRDM1 Proteine) down-regulates HGAL and LMO2 (zeige LMO2 Proteine); PRDM1 (zeige PRDM1 Proteine) directly binds to promoters of both HGAL and LMO2 (zeige LMO2 Proteine) and represses genetic transcription.
show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement
HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites
molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
germinal center B-cell-expressed transcript 2 protein
, germinal center expressed transcript 2
, germinal center-associated signaling and motility protein
, germinal center-associated lymphoma protein
, human germinal center-associated lymphoma