anti-Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Antikörper

The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Zusätzlich bieten wir Ihnen DOK1 Kits (11) und DOK1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
DOK1 109978 Q9CRA0
DOK1 312477 Q4QQV2
DOK1 1796 Q99704
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Top anti-DOK1 Antikörper auf antikoerper-online.de

Showing 10 out of 222 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Pferd Kaninchen Unkonjugiert WB <b>WB Suggested Anti-DOK1 Antibody Titration: </b>0.2-1 ug/ml<br><b>Positive Control: </b>Transfected 293T 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Western blot analysis of anti-DOK1 Pab (ABIN392070) in HL-60 cell lysate. DOK1 (Arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Western blot analysis of DOK1 (arrow) using DOK1 Antibody (N-term) (ABIN392070). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected with the DOK1 gene (Lane 2). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Rind (Kuh) Kaninchen Unkonjugiert IC, IF, IHC, WB Immunofluorescent analysis of DOK1 staining in K562 cells. Formalin-fixed cells were permeabilized with 0.1% Triton X-100 in TBS for 5-10 minutes and blocked with 3% BSA-PBS for 30 minutes at room temperature. Cells were probed with the primary antibody i Immunohistochemical analysis of DOK1 staining in human breast cancer formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated wit 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IF, IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$368.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from Jurkat cells, using p62 Dok (Ab-362) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p62 Dok (Ab-362) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from K562 cells, treated with Starvation 24h, using p62 Dok (Ab-398) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using p62 Dok (Ab-398) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details

DOK1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Am meisten referenzierte anti-DOK1 Antikörper

  1. Human Monoclonal DOK1 Primary Antibody für IF, IP - ABIN968157 : Carpino, Wisniewski, Strife, Marshak, Kobayashi, Stillman, Clarkson: p62(dok): a constitutively tyrosine-phosphorylated, GAP-associated protein in chronic myelogenous leukemia progenitor cells. in Cell 1997 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal DOK1 Primary Antibody für IHC - ABIN966766 : Songyang, Yamanashi, Liu, Baltimore: Domain-dependent function of the rasGAP-binding protein p62Dok in cell signaling. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 Pubmed References

  3. Human DOK1 Primary Antibody für IHC - ABIN966764 : Némorin, Duplay: Evidence that Llck-mediated phosphorylation of p56dok and p62dok may play a role in CD2 signaling. in The Journal of biological chemistry 2000 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal DOK1 Primary Antibody für IHC - ABIN966767 : Wick, Dong, Hu, Langlais, Liu: Insulin receptor-mediated p62dok tyrosine phosphorylation at residues 362 and 398 plays distinct roles for binding GTPase-activating protein and Nck and is essential for inhibiting insulin-stimulated activation of Ras and Akt. in The Journal of biological chemistry 2001 (PubMed)
    Show all 4 Pubmed References

  5. Human DOK1 Primary Antibody für IHC - ABIN966765 : Simoncic, Bourdeau, Lee-Loy, Rohrschneider, Tremblay, Stanley, McGlade: T-cell protein tyrosine phosphatase (Tcptp) is a negative regulator of colony-stimulating factor 1 signaling and macrophage differentiation. in Molecular and cellular biology 2006 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal DOK1 Primary Antibody für WB - ABIN515056 : Barrett, Evans, Frolov, Britton, Pellet-Many, Yamaji, Mehta, Bandopadhyay, Li, Brandner, Zachary, Frankel: A crucial role for DOK1 in PDGF-BB-stimulated glioma cell invasion through p130Cas and Rap1 signalling. in Journal of cell science 2014 (PubMed)

Weitere Antikörper gegen DOK1 Interaktionspartner

Mouse (Murine) Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Interaktionspartner

  1. These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8 (zeige CD8A Antikörper)(+) T cells and promotes memory formation.

  2. Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8 (zeige CD8A Antikörper)(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.

  3. this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation

  4. Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A (zeige IL17A Antikörper) and IL-22 (zeige IL22 Antikörper) expression.

  5. Dok1 knockdown attenuated TLR2 (zeige TLR2 Antikörper)-induced NF-kappaB (zeige NFKB1 Antikörper) activation and IL-6 (zeige IL6 Antikörper) production in microglia.

  6. Triple Dok1 Doc2 (zeige DOC2A Antikörper) Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.

  7. Dok-1 overexpression promotes the generation of an innate-like CD8 (zeige CD8A Antikörper)(+) T-cell population that expresses Eomesodermin (zeige EOMES Antikörper).

  8. Studies using SHIP-1 (zeige INPP5D Antikörper) shRNA, knockout mice and decoy inhibitors further indicate that CD4 (zeige CD4 Antikörper)-mediated inhibition of TCR-mediated T cell activation is SHIP-1 (zeige INPP5D Antikörper) and Dok-1/2 dependent, and involves SHIP-1 (zeige INPP5D Antikörper) hydrolysis of Phosphatidylinositol 3,4,5-trisphosophate

  9. Dok-1 and Dok-2 deficiency induces osteopenia by activation of osteoclasts.

  10. these findings indicate that Dok-1, Dok-2, and Dok-3 (zeige DOK3 Antikörper) cooperatively suppress aggressive HS

Human Docking Protein 1, 62kDa (Downstream of tyrosine Kinase 1) (DOK1) Interaktionspartner

  1. Taken together, these results indicate that ATRA-enhanced expression of DOK1 activates PPARgamma (zeige PPARG Antikörper) leading to inhibition of cell proliferation and enhancement of cell apoptosis in MCF-7 cell.

  2. DOK1 was identified as a prognostic factor for non-metastatic CRC (zeige CALR Antikörper), and, via its drugability by PPARgamma (zeige PPARG Antikörper)-agonist, may constitute a potential target for future cancer treatments.

  3. DOK3 (zeige DOK3 Antikörper) expression was not altered much in HTLV-1-infected T cells.

  4. Results indicate that hypermethylation of tumor suppressor protein (zeige TP53 Antikörper) RASSF1A (zeige RASSF1 Antikörper) and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.

  5. Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (zeige GTF2H1 Antikörper) (downstream of tyrosine kinase 1) (Dok1) interaction.

  6. results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (zeige CRK Antikörper)-transformed cells via recruitment and/or activation of RasGAP (zeige RASA1 Antikörper)

  7. Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (zeige PTBP1 Antikörper) domain of phosphoprotien Dok1 either in the native or in the near native conditions.

  8. Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.

  9. point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (zeige PTBP1 Antikörper) domain

  10. A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.

DOK1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.

Genbezeichner und Symbole assoziert mit DOK1

  • ADP-ribosyltransferase 4 (Art4) Antikörper
  • docking protein 1 (Dok1) Antikörper
  • docking protein 1 (DOK1) Antikörper
  • 4432404K01Rik Antikörper
  • ARTC4 Antikörper
  • AW557123 Antikörper
  • DO Antikörper
  • Dok-1 Antikörper
  • DOK1 Antikörper
  • P62DOK Antikörper

Bezeichner auf Proteinebene für DOK1

ADP-ribosyltransferase C2 and C3 toxin-like 4 , NAD(P)(+)--arginine ADP-ribosyltransferase 4 , ecto-ADP-ribosyltransferase 4 , mono(ADP-ribosyl)transferase 4 , downstream of tyrosine kinase 1 , p62(dok) , downstream of tyrosine kinase-1 , Downstream of tyrosine kinase 1 , docking protein 1 , docking protein 1 (downstream of tyrosine kinase 1) , pp62

GENE ID SPEZIES
109978 Mus musculus
13448 Mus musculus
312477 Rattus norvegicus
1796 Homo sapiens
483100 Canis lupus familiaris
100233179 Sus scrofa
514962 Bos taurus
Ausgewählte Anbieter für anti-DOK1 (DOK1) Antikörper
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