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CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Zusätzlich bieten wir Ihnen CFTR Kits (43) und CFTR Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.
Showing 10 out of 360 products:
Chicken Monoclonal CFTR Primary Antibody für BP, FACS - ABIN152670
Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995
Show all 9 Pubmed References
Human Monoclonal CFTR Primary Antibody für IF, IHC (p) - ABIN5575335
Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. in Science (New York, N.Y.) 1989
A high prevalence of the CFTR V232D mutation in patients with cystic fibrosis (zeige S100A8 Antikörper) and the mutation was found to be associated with the phenotype of pulmonary disease.
Archived data from 15 adult cystic fibrosis (zeige S100A8 Antikörper) patients with the CFTR c.1652GA (G551D) mutation.
The pancreatic insufficiency (PI) status was associated with clinical variables and single nucleotide polymorphisms (SNPs) related with inflammatory response considering cystic fibrosis transmembrane conductance regulator (CFTR) mutations.
The data suggest that miR (zeige MLXIP Antikörper)-200b may be a suitable target for modulating CFTR levels in vivo.
The mutations found in the promoter region of the CFTR gene in Chinese congenital bilateral absence of the vas (zeige AVP Antikörper) deferens patients were different from those in Caucasian populations.
Intragenic CFTR Duplication and 5T/12TG Variant in a Patient with Non-Classic Cystic Fibrosis (zeige S100A8 Antikörper).
This study discovers an essential role of CFTR in mediating the retinoic acid-dependent signaling for stem cell differentiation and embryonic development (zeige PLCG1 Antikörper).
CFTR stabilizes beta-catenin (zeige CTNNB1 Antikörper) and prevents its degradation, defect of which results in the activation of NF-kappaB (zeige NFKB1 Antikörper)-mediated inflammatory cascade
There is significant variability in both the frequency and type of mutations present in our study population and in what has been reported in other Latin American countries. It is necessary to perform studies that use complete sequencing technology for the CFTR gene to identify other mutations present in our population
F508 deletion in CFTR was significantly positively associated with chronic pancreatitis (CP) risk in the overall analysis. Indians with F508 deletion had much higher CP prevalence than non-Indians. Interestingly, F508 deletion was also associated with CP and idiopathic CP risk in subgroup analysis stratified by aeitiology, using the fixed effects model. [review, meta-analysis]
NDPK-A (zeige NME1 Antikörper) exists in a functional cellular complex with AMPK (zeige PRKAA2 Antikörper) and CFTR in airway epithelia, and NDPK-A (zeige NME1 Antikörper) catalytic function is required for the AMPK (zeige PRKAA2 Antikörper)-dependent regulation of CFTR
Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.
wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase (zeige DNAH8 Antikörper) cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.
The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC (zeige ABCB6 Antikörper)) transporters.
These data suggest that the Xenopus P2Y1 receptor (zeige P2RY1 Antikörper) can increase both cyclic AMP (zeige TMPRSS5 Antikörper)/protein kinase A and calcium/protein kinase C (zeige PKC Antikörper) levels and that the PKC (zeige PKC Antikörper) pathway is involved in CFTR activation via potentiation of the PKA pathway.
these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation
CFTR physically interacts with beta-catenin (zeige CTNNB1 Antikörper), defect of which leads to premature degradation of beta-catenin (zeige CTNNB1 Antikörper) and suppressed activation of beta-catenin (zeige CTNNB1 Antikörper) signaling.
CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.
Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.
a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis (zeige S100A8 Antikörper).
results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon (zeige GCG Antikörper) secretion in alpha cells
This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.
CFTR is a tumor suppressor gene in murine and human colorectal cancer
Insulin (zeige INS Antikörper) stimulation of Akt1 (zeige AKT1 Antikörper) and Akt2 (zeige AKT2 Antikörper) signaling in Cystic fibrosis (zeige S100A8 Antikörper) airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.
Biotinylation and streptavidin pull-down assays confirmed that CAL (zeige S100A11 Antikörper) dramatically reduces the expression level of total and cell surface Mrp2 (zeige ABCC2 Antikörper) in Huh-7 cells. Our findings suggest that CAL (zeige S100A11 Antikörper) interacts with Mrp2 (zeige ABCC2 Antikörper) and is a negative regulator of Mrp2 (zeige ABCC2 Antikörper) expression.
Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.
Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.
Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.
TGF-beta1 (zeige TGFB1 Antikörper), via TGF-beta1 (zeige TGFB1 Antikörper) receptor I and p38 MAPK (zeige MAPK14 Antikörper) signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.
The esophageal submucosal glands (SMG (zeige SNRPG Antikörper)) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.
data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis (zeige S100A8 Antikörper) are likely primary
The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.
CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation
These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis (zeige S100A8 Antikörper) pigs, reveal some spared function in the DeltaF508 vs. null piglets.
causal link between CFTR mutations and partial or total vas (zeige AVP Antikörper) deferens and/or epididymis atresia at birth
conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I (zeige DNASE1 Antikörper) hypersensitive sites showed high homology in cow and pig.
Results demonstrate functional coupling between Cftr and Slc26a6 (zeige SLC26A6 Antikörper)-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.
Molecular dynamics of the cryo-EM CFTR structure
Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.
Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis (zeige S100A8 Antikörper)-causing missense mutational sites are identical.
Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis (zeige S100A8 Antikörper) of the human pancreas.
This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.
cAMP-dependent chloride channel
, channel conductance-controlling ATPase
, cystic fibrosis transmembrane conductance regulator
, cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7)
, cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
, ATP-binding cassette sub-family C member 7
, ATP-binding cassette transporter sub-family C member 7
, ATP-binding cassette, subfamily c, member 7
, cystic fibrosis transmembrane conductance regulator homolog
, cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7
, CFTR chloride channel
, chloride channel
, CFTR cAMP-dependent chloride channel protein
, Channel conductance-controlling ATPase