anti-Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Antikörper

CFTR encodes a member of the ATP-binding cassette (ABC) transporter superfamily. Zusätzlich bieten wir Ihnen CFTR Kits (43) und CFTR Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
CFTR 1080 P13569
CFTR 12638 P26361
CFTR 24255 P34158
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Top anti-CFTR Antikörper auf antikoerper-online.de

Showing 10 out of 358 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Huhn Maus Unkonjugiert BP, FACS, ICC, IF, IHC, IHC (p), IP, Neut, WB Immunocytochemistry/Immunofluorescence: CFTR Antibody (CF3) [ABIN152670] - CFTR staining (green), F-Actin staining with Phalloidin (red) and nuclei with DAPI (blue) is shown. Cells were grown on chamber slides and fixed with formaldehyde prior to staining. Cells were probed without (control) or with or an antibody recognizing CFTR at a dilution of 1:100-1:200 over night at 4C, washed with PBS and incubated with a DyLight-488 conjugated. Immunohistochemistry-Paraffin: CFTR Antibody (CF3) [ABIN152670] - Cancer biopsies of deparaffinized Human colon carcinoma tissue. 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$516.98
Details
Human Kaninchen Unkonjugiert IHC, WB Immunohistochemical analysis of CFTR staining in human brain formalin fixed paraffin embedded tissue section. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH 6.0). The section was then incubated with the antibody at room temperature and detected using an HRP conjugad compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX. w Western blot analysis of CFTR expression in SHSY5Y (A), NIH3T3 (B) whole cell lysates. 200 μL Anmelden zum Anzeigen 13 bis 14 Tage
$487.50
Details
Human Kaninchen Unkonjugiert IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, using CFTR (Ab-737) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using CFTR (Ab-737) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Rind (Kuh) Ziege Unkonjugiert IHC, IHC (p) Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Prostate: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB Western Blot (WB) analysis of specific cells using CFTR Polyclonal Antibody. 100 μL Anmelden zum Anzeigen 16 Days
$181.73
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB ABIN6269852 at 1/100 staining rat kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6269852 at 1/100 staining human kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, WB ABIN6271251 at 1/200 staining Mouse kidney tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. ABIN6271251 at 1/200 staining Rat spleen tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IHC, IHC (p) Immunohistochemistry-Paraffin: CFTR Antibody [NBP1-89315] - Staining of human pancreas shows strong membranous positivity in intercalated ducts. Western Blot: CFTR Antibody [NBP1-89315] - Lane 1: Marker [KDa] 250, 130, 100, 70, 55, 35, 25, 15, 10 Lane 2: Human cell line MOLT-4 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$494.38
Details
Human Maus Unkonjugiert IF, IHC, IHC (p), IP Human Lung: Formalin-Fixed, Paraffin-Embedded (FFPE) Anti-CFTR antibody IHC staining of human lung. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 250 μL Anmelden zum Anzeigen 11 bis 14 Tage
$727.83
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of CFTR using HUVEC whole cell lysates 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details

Am meisten referenzierte anti-CFTR Antikörper

  1. Chicken Monoclonal CFTR Primary Antibody für BP, FACS - ABIN152670 : Walker, Watson, Holmes, Edelman, Banting et al.: Production and characterisation of monoclonal and polyclonal antibodies to different regions of the cystic fibrosis transmembrane conductance regulator (CFTR): detection of immunologically related ... in Journal of cell science 1995 (PubMed)
    Show all 9 Pubmed References

  2. Human Monoclonal CFTR Primary Antibody für IF, IHC (p) - ABIN5575335 : Riordan, Rommens, Kerem, Alon, Rozmahel, Grzelczak, Zielenski, Lok, Plavsic, Chou: Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. in Science (New York, N.Y.) 1989 (PubMed)

Weitere Antikörper gegen CFTR Interaktionspartner

Human Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Most bicarbonate efflux in Calu-3 cells is mediated by CFTR.

  2. by associating cell-type-specific expression programs with key disease genes (like CFTR), a new cellular narrative for airways disease is established

  3. NDPK-A (not -B) interacts with CFTR through reciprocal AMPK binding/control, whereas NDPK-B (not -A) binds directly to CFTR. [review]

  4. STX8 silencing restores the function ofDeltaF508-CFTR.

  5. Compound heterozygous variants in CFTR were identified in two pedigrees with congenital bilateral absence of vas deferens.

  6. The structure of CFTR provides a better understanding of why the G178R, R352Q, L927P, and G970R/D mutations would impede conformational changes of CFTR and lead to cystic fibrosis.

  7. observed that inhibition of both CFTR and NBC decreased HCO3(-) influx, resulting in lower PKA activity

  8. CFTR enhances ANO6 activity and supports apoptosis.

  9. CFTR silencing promoted the expression of NF-kappaB-p65 and NF-kappaB-p50, and the results of CFTR overexpression were reversed.

  10. The majority of CFTR variants detected have been associated with a less severe cystic fibrosis phenotype. A wide spectrum of CFTR variants was identified, confirming the highest CFTR allelic heterogeneity previously reported in Mediterranean country. Additionally, better knowledge about the CFTR sequence variation spectrum may contribute to more efficient genetic testing in the Portuguese population

  11. Defective CFTR and NOX/GR activity imbalance both contribute to NADPH and GSH level decrease and ROS overproduction in CF cells.

  12. FAU knockdown increased the plasma membrane targeting and function of F508del-CFTR, but not of wild-type CFTR. Investigation into the mechanism of action revealed a preferential physical interaction of FAU with mutant CFTR, leading to its degradation.

  13. KIFC1 interacts with F508del-CFTR.

  14. Results suggest that dynamic cystic fibrosis transmembrane conductance regulator (CFTR) conformational changes of the outermost part of the Cl- permeation pathway take place as the channel opens and closes

  15. In this report we target premature termination codons (PTCs) in messages encoding both a fluorescent reporter protein and the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) protein transiently transfected into human epithelial cells. We demonstrate that while on-target editing is efficient, off-target editing is extensive, both within the targeted message and across the entire transcriptome of the transfected

  16. Studies indicate that the most common mutation in cystic fibrosis (CF), the deletion of a phenylalanine at position 508, involves dramatic alterations of the cystic fibrosis transmembrane conductance regulator (CFTR) traffic, processing and folding.

  17. CFTR silencing results in lipid homeostasis disruption and mitochondrial dysfunction in intestinal epithelial cells.

  18. Roles of CFTR in fundamental cellular processes including transformation, survival, proliferation, migration, invasion and epithelial-mesenchymal transition in cancer cells, highlighting the signaling pathways involved. Finally, the association of CFTR expression levels with patient prognosis, and the potential of CFTR as a cancer prognosis indicator in human malignancies will be discussed. [review]

  19. CFTR exhibited an inhibitory role in the malignancy of lung adenocarcinoma A549 cells

  20. in Caco-2 CFTR-shRNA cells, the EGFR ligand EREG is overexpressed due to an active IL-1beta autocrine loop that indirectly activates EGFR, constituting new signaling effectors for the CFTR signaling pathway, downstream of CFTR, Cl(-) , and IL-1beta.

Xenopus laevis Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Study conclude that when both CFTR and NPT2a are expressed in X. laevis oocytes, CFTR confers to NPT2a a cAMPi-dependent trafficking to the membrane.

  2. NDPK-A exists in a functional cellular complex with AMPK and CFTR in airway epithelia, and NDPK-A catalytic function is required for the AMPK-dependent regulation of CFTR

  3. This study discovers an essential role of CFTR in mediating the retinoic acid-dependent signaling for stem cell differentiation and embryonic development.

  4. wild-type CFTR channel gating cycle is essentially irreversible and tightly coupled to the ATPase cycle, and that this coupling is completely destroyed by the NBD2 Walker B mutation D1370N but only partially disrupted by the NBD1 Walker A mutation K464A.

  5. The cystic fibrosis transmembrane conductance regulator (CFTR) is a protein that belongs to the superfamily of ATP binding cassette (ABC) transporters.

  6. These data suggest that the Xenopus P2Y1 receptor can increase both cyclic AMP/protein kinase A and calcium/protein kinase C levels and that the PKC pathway is involved in CFTR activation via potentiation of the PKA pathway.

Mouse (Murine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. by associating cell-type-specific expression programs with key disease genes (like CFTR), a new cellular narrative for airways disease is established

  2. Results show that CFTR channels are present in alpha cells and act as important negative regulators of cAMP-enhanced glucagon secretion through effects on alpha cell membrane potential. These data support that loss-of-function mutations in CFTR contributes to dysregulated glucagon secretion in Cystic Fibrosis-related diabetes.

  3. these results demonstrate that CFTR prevents inflammation and atherogenesis via inhibition of NFkappaB and MAPKs activation

  4. CFTR physically interacts with beta-catenin, defect of which leads to premature degradation of beta-catenin and suppressed activation of beta-catenin signaling.

  5. CFTR attaches tumor suppressor PTEN to the membrane and promotes anti Pseudomonas aeruginosa immunity.

  6. Our studies reveal a novel function for CFTR in antiviral immunity and demonstrate that the DeltaF508 mutation in cftr is coupled to an impaired adaptive immune response. This important insight could open up new approaches for patient care and treatment.

  7. a new and more convenient approach, based on in vivo imaging analysis, has been set up to evaluate the inflammatory response in the lung of CFTR-deficient (CF) mice, a murine model of cystic fibrosis.

  8. results reveal that by potentiating adenosine triphosphate-sensitive K+ (KATP) channel, cystic fibrosis transmembrane conductance regulator CFTR acts as a glucose-sensing negative regulator of glucagon secretion in alpha cells

  9. This study demonstrates that CFTR plays an important role in tenogenic differentiation and tendon regeneration by inhibiting the beta-catinin/pERK1/2 signaling pathway.

  10. CFTR is a tumor suppressor gene in murine and human colorectal cancer

  11. Insulin stimulation of Akt1 and Akt2 signaling in Cystic fibrosis airway cells was diminished compared with that observed in airway cells expressing wild-type CFTR.

  12. Biotinylation and streptavidin pull-down assays confirmed that CAL dramatically reduces the expression level of total and cell surface Mrp2 in Huh-7 cells. Our findings suggest that CAL interacts with Mrp2 and is a negative regulator of Mrp2 expression.

  13. Myelinosomes secreted from testis somatic TM4 Sertoli cells provide the release of aggregate-prone mutant, but not normal Huntingtin (Htt) exon1. Myelinosomes also support the release of other aggregate-prone mutant protein responsible for cystic fibrosis (CF), F508delCFTR.

  14. ATP8B1 is important for proper CFTR expression and function.

  15. Loss of cystic fibrosis transmembrane regulator impairs intestinal oxalate secretion

  16. CFTR plays a role in suppressing MAPK/NF-kappaB to relieve inflammation, reduce proliferation and promote differentiation of keratinocytes, and thus promotes cutaneous wound healing.

  17. physiological fetal hypercalcemia, acting on the CaSR, promotes human fetal lung development via cAMP-dependent opening of CFTR.

  18. CFTR expressed by alveolar or peritoneal macrophages regulates acute proinflammatory responses.

  19. CFTR silencing in pancreatic beta-cells significantly reduced insulin output in response to glucose, and made the cells more sensitive to oxidative stress.

  20. Cftr KO crypt epithelium maintains an alkaline pHi as a consequence of losing both Cl(-) and HCO3 (-) efflux, which impairs pHi regulation by Ae2.

Pig (Porcine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results suggest that acetylcholine does not regulate the activity of the CFTR in tracheal epithelia of pigs which opposes observation from studies using mice airway epithelium.

  2. Expression of CFTR-F508del interferes with smooth muscle cell calcium handling and decreases aortic responsiveness.

  3. Pseudomonas aeruginosa and other bacteria into the lumen of intact isolated swine tracheas triggers CFTR-dependent airway surface liquid secretion by the submucosal glands.

  4. TGF-beta1, via TGF-beta1 receptor I and p38 MAPK signaling, reduces CFTR expression to impair CFTR-mediated anion secretion, which would likely compound the effects associated with mild CFTR mutations and ultimately would compromise male fertility.

  5. The esophageal submucosal glands (SMG) secrete HCO(3)(-) and mucus into the esophageal lumen, where they contribute to acid clearance and epithelial protection. We investigated the presence of CFTR, its involvement in the secretion process, and the effect of cAMP on HCO3 secretion in this tissue. This is the first report on the presence of CFTR channels in the esophagus.

  6. data suggest that loss of CFTR directly alters Schwann cell function and that some nervous system defects in people with cystic fibrosis are likely primary

  7. The data suggest, that during bacterial infections and resulting release of proinflammatory cytokines, the glands are stimulated to secrete fluid, and this response is mediated by cAMP-activated CFTR.

  8. CFTR is required for maximal liquid absorption by lung alveoli under cAMP stimulation

  9. These findings reveal differences between nasal and tracheal glands, show defective fluid secretion in nasal glands of cystic fibrosis pigs, reveal some spared function in the DeltaF508 vs. null piglets.

  10. causal link between CFTR mutations and partial or total vas deferens and/or epididymis atresia at birth

  11. These data provide a molecular basis for interpreting enamel disease associated with disruptions to CFTR and AE2 expression.

  12. These results suggest that limited DeltaF508-mutant CFTR activity in is insufficient to prevent lung or gastrointestinal disease in CF pigs.

  13. CFTR mediates cAMP-stimulated Cl- secretion in a well-differentiated thyroid culture model. Knockout of CFTR promotes increased Na+ absorption by a mechanism other than increased epithelial sodium channel expression.

  14. These results indicate that CFTR provides the predominant transcellular pathway for Cl and HCO in porcine airway epithelia, and reduced anion permeability may initiate CF airway disease.

  15. Data show that PDE3A inhibition augments CFTR-dependent submucosal gland secretion and actin skeleton disruption decreases secretion.

  16. Expression of pCFTR was found to largely resemble that of hCFTR except for the kidney, brain, and cutaneous glands, which lack expression in pigs.

  17. The role of CFTR in submucosal gland fluid secretion was tested in pig airways. The reduced rate of gland fluid secretion after CFTR inhibition shown here provides strong evidence for the involvement of CFTR in glandular epithelial fluid transport.

  18. significant differences in CFTR channel mRNA and protein levels were present in atrial and ventricular cells, but not in regional ventricular cells across the ventricular wall from subepicardium to subendocardium

  19. analysis of species-dependent differences of CFTR-DeltaF508 in human, pig and mouse

  20. The mild cellular processing defect of pig DeltaF508-CFTR suggests that its gene-targeted pig model may not develop the lung and pancreatic phenotypes seen in CF patients.

Cow (Bovine) Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. conserved CFTR sequences between species are examined for potential regulatory elements. Regions of introns 2, 3, 10, 17a, 18, and 21 and 3' flanking sequence corresponding to human CFTR DNase I hypersensitive sites showed high homology in cow and pig.

Guinea Pig Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. Results demonstrate functional coupling between Cftr and Slc26a6-like Cl(-)/HCO(3)(-) exchange activity in apical membrane of guinea pig pancreatic interlobular duct.

Zebrafish Cystic Fibrosis Transmembrane Conductance Regulator (ATP-Binding Cassette Sub-Family C, Member 7) (CFTR) Interaktionspartner

  1. study revealed an important role of cystic fibrosis transmembrane conductance regulator (CFTR) acting as an ion channel in regulating primordial germ cell migration during early embryogenesis

  2. Molecular dynamics of the cryo-EM CFTR structure

  3. Study presents the structure of zebrafish CFTR in the phosphorylated, ATP-bound conformation, determined by cryoelectron microscopy to 3.4 A resolution. Comparison of the two conformations shows major structural rearrangements leading to channel opening.

  4. Study determined the structure of the zebrafish CFTR by electron cryo-microscopy to 3.7 A resolution; shares 55% sequence identity with human CFTR, and 42 of the 46 cystic-fibrosis-causing missense mutational sites are identical.

  5. Cftr mutant zebrafish develops pancreatic destruction similar to cystic fibrosis of the human pancreas.

CFTR Antigen-Profil

Protein Überblick

This gene encodes a member of the ATP-binding cassette (ABC) transporter superfamily. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily that is involved in multi-drug resistance. The encoded protein functions as a chloride channel and controls the regulation of other transport pathways. Mutations in this gene are associated with the autosomal recessive disorders cystic fibrosis and congenital bilateral aplasia of the vas deferens. Alternatively spliced transcript variants have been described, many of which result from mutations in this gene.

Genbezeichner und Symbole assoziert mit CFTR

  • cystic fibrosis transmembrane conductance regulator (CFTR) Antikörper
  • cystic fibrosis transmembrane conductance regulator (cftr-A) Antikörper
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (CFTR) Antikörper
  • cystic fibrosis transmembrane conductance regulator (Cftr) Antikörper
  • cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (cftr) Antikörper
  • abc35 Antikörper
  • abcc7 Antikörper
  • AW495489 Antikörper
  • CF Antikörper
  • CFTR Antikörper
  • cftr/mrp Antikörper
  • dJ760C5.1 Antikörper
  • mrp7 Antikörper
  • RGD1561193 Antikörper
  • si:dkey-270i2.2 Antikörper
  • tnr-cftr Antikörper
  • xcftr Antikörper

Bezeichner auf Proteinebene für CFTR

cAMP-dependent chloride channel , channel conductance-controlling ATPase , cystic fibrosis transmembrane conductance regulator , cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) , cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7) , ATP-binding cassette sub-family C member 7 , ATP-binding cassette transporter sub-family C member 7 , ATP-binding cassette, subfamily c, member 7 , cystic fibrosis transmembrane conductance regulator homolog , cystic fibrosis transmembrane conductance regulator homolog; ATP-binding cassette, subfamily c, member 7 , CFTR chloride channel , chloride channel , CFTR cAMP-dependent chloride channel protein , Channel conductance-controlling ATPase , abcc7

GENE ID SPEZIES
1080 Homo sapiens
373725 Xenopus laevis
780954 Monodelphis domestica
100137161 Nomascus leucogenys
12638 Mus musculus
24255 Rattus norvegicus
100049619 Gallus gallus
492302 Canis lupus familiaris
100071259 Equus caballus
403154 Sus scrofa
281067 Bos taurus
443347 Ovis aries
100009471 Oryctolagus cuniculus
463674 Pan troglodytes
100137035 Pongo abelii
100719898 Cavia porcellus
100381094 Xenopus laevis
100126675 Papio anubis
559080 Danio rerio
Ausgewählte Anbieter für anti-CFTR (CFTR) Antikörper
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