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Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway.
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Human Polyclonal CABIN1 Primary Antibody für ICC, IF - ABIN4286951
Wen, Zhou, Liu, Wang, Zhang, Liang: Effect of the knockdown of Cabin1 on p53 in glomerular podocyte. in Journal of receptor and signal transduction research 2016
Results indicate an important role for LMP1 (zeige PDLIM7 Antikörper) and Cabin1 in regulating apoptosis in nasopharyngeal carcinoma cells in response to genotoxic stress.
Two new susceptibility loci for amyotrophic lateral sclerosis in the Han Chinese population in chromosome 1, CAMK1G (zeige CAMK1G Antikörper) and chromosome 22, SUSD2 and CABIN1.
NHRD domain of UBN1 (zeige UBN1 Antikörper) as being an essential region for HIRA (zeige HIRA Antikörper) interaction and chromatin organization by the HUCA complex
Data show that, like HIRA (zeige HIRA Antikörper), UBN1 (zeige UBN1 Antikörper), and ASF1a (zeige ASF1A Antikörper), CABIN1 is involved in heterochromatinization of the genome of senescent human cells.
CABIN1 may not confer increased susceptibility for schizophrenia in the Japanese population.
Crystal structure of the MADS-box/MEF2S domain of human MEF2B (zeige MEF2B Antikörper) bound to a motif of the transcriptional co-repressor Cabin1 and DNA at 2.2 A resolution
there is a 13-amino acid region within CN that is essential for the interaction with NFAT (zeige NFATC1 Antikörper) and with two other CN-binding proteins, AKAP79 (zeige AKAP5 Antikörper) and Cabin-1
Here, we report that Cabin1 has additional CN binding domain in its 701-900 amino acid residues.
Cabin1 inhibits p53 (zeige TP53 Antikörper) function on chromatin in the quiescent state; the presence of inactive p53 (zeige TP53 Antikörper) on some promoters might allow a prompt response upon DNA damage.
the association of CAIN (zeige NUP214 Antikörper) with intracellular domains involved in mGluR (zeige GRM8 Antikörper)/G protein coupling provides a mechanism by which Group I mGluR (zeige GRM8 Antikörper) endocytosis and signaling are regulated
calcineurin B1 plays a key role in seizure-induced dendrite growth suppression and may contribute to the neurobehavioral comorbidities of childhood epilepsy
Calpain-dependent cleavage activates calcineurin to mediate calcium-triggered cell death.
Calcineurin plays an important role in the T-cell receptor-mediated signal transduction pathway. The protein encoded by this gene binds specifically to the activated form of calcineurin and inhibits calcineurin-mediated signal transduction. The encoded protein is found in the nucleus and contains a leucine zipper domain as well as several PEST motifs, sequences which confer targeted degradation to those proteins which contain them. Alternative splicing results in multiple transcript variants encoding two different isoforms.
calcineurin binding protein 1
, calcineurin-binding protein cabin-1-like
, calcineurin binding protein cabin 1
, calcineurin inhibitor
, calcineurin-binding protein cabin-1
, protein phosphatase 3 inhibitor