CD274 Molecule Proteine (CD274)

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Zusätzlich bieten wir Ihnen PD-L1 Antikörper (366) und PD-L1 Kits (53) und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
CD274 60533 Q9EP73
CD274 29126 Q9NZQ7
CD274 499342  
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Top PD-L1 Proteine auf antikoerper-online.de

Showing 10 out of 83 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 30 bis 35 Tage
$4,744.22
Details
Insektenzellen Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Anmelden zum Anzeigen 50 bis 55 Tage
$6,616.87
Details
HEK-293 Cells Human His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$485.00
Details
Insektenzellen Maus rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Anmelden zum Anzeigen 50 bis 55 Tage
$4,649.05
Details
HEK-293 Cells Maus His tag 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$615.00
Details
Human Cells Human Fc Tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
Human Cells Maus His tag 100 μg Anmelden zum Anzeigen 20 bis 21 Tage
$250.80
Details
HEK-293 Cells Human His tag Human PD-L1, His Tag (HPLC-verified) on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 98%. Immobilized Human PD-L1, His Tag (HPLC-verified)  with a linear range of 0.05-1 μg/mL. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$330.00
Details
Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$672.00
Details
Escherichia coli (E. coli) Maus His tag,T7 tag 100 μg Anmelden zum Anzeigen 15 bis 18 Tage
$720.00
Details

CD274 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine) , , , , ,
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Human , , , , , , , , , ,
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Rat (Rattus) ,
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Am meisten referenzierte PD-L1 Proteine

  1. Mouse (Murine) PD-L1 Protein expressed in Human Cells - ABIN2007141 : Trabattoni, Saresella, Biasin, Boasso, Piacentini, Ferrante, Dong, Maserati, Shearer, Chen, Clerici: B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. in Blood 2003 (PubMed)
    Show all 5 Pubmed References

Weitere Proteine zu CD274 Molecule (CD274) Interaktionspartnern

Mouse (Murine) CD274 Molecule (CD274) Interaktionspartner

  1. Genetic ablation of a single immune-regulatory molecule in this model [i.e., B7-homolog 1 (B7-H1, PD-L1)] not only significantly increased incidence of spontaneous CNS autoimmunity and aggravated disease course, especially in the later stages of disease, but also importantly resulted in encephalitogenic T-cell infiltration and lesion formation in normally unaffected brain regions.

  2. Studied the possible role of PD-L1 on malignant melanoma initiating cells (MMICs). Found blocking of PD-L1 in melanoma cell lines impaired tumorsphere formation and induced the apoptosis. Also, blocking PD-L1 inhibited tumor growth in vivo.

  3. B7-H1 induction in keratinocytes may play a crucial role in the protection from CD4 (zeige CD4 Proteine)+ T cell-mediated tissue inflammation by exogenous antigens delivered from the mucosal surface in oral cavity

  4. Interferon (zeige IFNA Proteine)-related secretome from direct interaction between immune cells and tumor cells is required for upregulation of PD-L1 in tumor cells.

  5. RAS signaling can upregulate tumor cell PD-L1 expression through a mechanism involving increases in PD-L1 mRNA stability via modulation of the AU-rich element-binding protein tristetraprolin (zeige ZFP36 Proteine).

  6. Data (including data from studies in transgenic/knockout mice) suggest that T-cell expression of Mirn155 is required to limit melanoma growth; miR (zeige MLXIP Proteine)-155, Pdcd1 (zeige PDCD1 Proteine), Pdcd1l1, and Ctla4 (zeige CTLA4 Proteine) appear to regulate overlapping pathways promoting antitumor immunity. [Mirn155 = microRNA 155; Pdcd1 (zeige PDCD1 Proteine) = programmed cell death 1 (zeige PDCD1 Proteine) protein; Pdcd1l1 = programmed cell death 1 ligand 1 protein; Ctla4 (zeige CTLA4 Proteine) = cytotoxic T-lymphocyte-associated protein 4 (zeige CTLA4 Proteine)]

  7. Expression of LAP/TGF-beta1 (zeige TGFB1 Proteine), CD80 (zeige CD80 Proteine), CD86 (zeige CD86 Proteine) and PD-L1 is significantly increased in tumor-infiltrating B cells (TIL (zeige TLR1 Proteine)-B) relative to splenic B cells. LAP/TGF-beta1 (zeige TGFB1 Proteine) expression on TIL (zeige TLR1 Proteine)-B progressively increased from 5.4+/-1.7% on day 8 to 43.1+/-6.1% by day 21 post tumor implantation.

  8. spleen-derived IFN-gamma (zeige IFNG Proteine) induces generation of PD-L1(+)-suppressive neutrophils.

  9. PD-L1 and PD-L2 (zeige PDCD1LG2 Proteine) in dermal fibroblasts is up-regulated by activated T cells in alopecia areata-affected skin.

  10. It was concluded that down-regulated expression of miR (zeige MLXIP Proteine)-143 and up-regulation of its direct target B7H1 may indicate a novel therapeutic method for radiation-induced thymic lymphoma by increased expression of miR (zeige MLXIP Proteine)-143 or inhibition of B7H1.

Human CD274 Molecule (CD274) Interaktionspartner

  1. In human gastrointestinal stromal tumors (GIST) cell lines, treatment with imatinib abrogated the IFNgamma-induced upregulation of PD-L1 via STAT1 (zeige STAT1 Proteine) inhibition. PD-1 (zeige PDCD1 Proteine)/PD-L1 blockade is a promising strategy to improve the effects of targeted therapy in GISTs

  2. PD-L1, IDO-1 (zeige IDO1 Proteine), and B7-H4 (zeige VTCN1 Proteine) are differentially expressed in human lung carcinomas and show limited co-expression. While PD-L1 and IDO-1 (zeige IDO1 Proteine) are associated with increased tumor-infiltrating lymphoycte and IFN-gamma (zeige IFNG Proteine) stimulation, B7-H4 (zeige VTCN1 Proteine) is not.

  3. Malignant peripheral nerve sheath tumors are characterized by low PD-L1 and absent PD-1 (zeige PDCD1 Proteine) expression with significant CD8 (zeige CD8A Proteine)+ tumor-infiltrating lymphocyte presence.

  4. A subset (4/210, 1.9%) of human SCLC patient cases exhibits massive expression of PD-L1 caused by focal amplification of CD274 Such tumors may be particularly susceptible to immune checkpoint blockade

  5. Low miR (zeige MLXIP Proteine)-138-5p and high PD-L1 levels correlated with shorter overall colorectal cancer patient survival

  6. osimertinib reduces PD-L1 mRNA expression and induces its protein degradation, suggesting that osimertinib may reactivate the immune activity of T cells in the tumor microenvironment in EGFR (zeige EGFR Proteine)-mutated NSCLC patients.

  7. Overexpression of PD-L1 and PD-L2 (zeige PDCD1LG2 Proteine) Is Associated with Poor Prognosis in Patients with Hepatocellular Carcinoma

  8. PD-L1 protein expression was a significant independent predictor of poor outcome in non-small cell lung cancer patients.

  9. High levels of CD274 are associated with Non-small Cell Lung Cancer.

  10. No correlation between PD-L1 expression and survival in non-small cell lung carcinomas.

Pig (Porcine) CD274 Molecule (CD274) Interaktionspartner

  1. These results suggest that the soluble recombinant proteins may be used to prepare monoclonal antibodies to block the PD-1 (zeige PDCD1 Proteine)/PD-L1 pathway.

  2. role of programmed death ligand-1 (PD-L1) during porcine circovirus type 2 (PCV2) infection and porcine circovirus associated diseases (PCVAD) development

  3. These data suggest that overexpression of PD-L1 and PD-L2 (zeige PDCD1LG2 Proteine) mRNA is one mechanism by which immunosupression of postweaning multisystemic wasting syndrome pigs occurs.

  4. Retinal PLD1 expression is enhanced in radial fibers of Muller cells with age. This finding suggests that PLD1 plays an important role in signal transduction of glial cells and neuronal cells in the retina.

  5. A porcine PD-L1 molecule was cloned using RACE (rapid amplification of cDNA ends) technology and sequenced (GenBank # AY837780); it showed high sequence homology with human PD-L1.

Cow (Bovine) CD274 Molecule (CD274) Interaktionspartner

  1. This study provides novel information for the understanding of signalling through PD-L1.

PD-L1 (CD274) Protein Überblick

Protein Überblick

Involved in the costimulatory signal essential for T- cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.

Genbezeichner und Symbole assoziert mit CD274 Molecule Proteine (CD274)

  • CD274 molecule (CD274)
  • CD274 antigen (Cd274)
  • CD274 molecule (Cd274)
  • programmed cell death 1 ligand 2 (PDCD1LG2)
  • A530045L16Rik Protein
  • B7-H Protein
  • B7H1 Protein
  • PD-L1 Protein
  • PDCD1L1 Protein
  • PDCD1LG1 Protein
  • PDL1 Protein
  • RGD1566211 Protein

Bezeichner auf Proteinebene für CD274 Molecule Proteine (CD274)

CD274 molecule , CD274 antigen , programmed cell death 1 ligand 1 , programmed cell death ligand 1 , B7 homolog 1 , PDCD1 ligand 1 , programmed death ligand 1

GENE ID SPEZIES
427224 Gallus gallus
464981 Pan troglodytes
716043 Macaca mulatta
100126721 Papio anubis
100357106 Oryctolagus cuniculus
60533 Mus musculus
29126 Homo sapiens
499342 Rattus norvegicus
100722088 Cavia porcellus
574058 Sus scrofa
484186 Canis lupus familiaris
533834 Bos taurus
427225 Gallus gallus
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