anti-Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) Antikörper

BUB1 encodes a kinase involved in spindle checkpoint function. Zusätzlich bieten wir Ihnen BUB1 Proteine (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
BUB1 699 O43683
BUB1 296137  
BUB1 12235 O08901
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Top anti-BUB1 Antikörper auf antikoerper-online.de

Showing 10 out of 156 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Maus Unkonjugiert ELISA, FACS, WB Western blot analysis using BUB1 mAb against human BUB1 (AA: 1-130) recombinant protein. (Expected MW is 41.3 kDa) Western blot analysis using BUB1 mAb against HEK293 (1) and BUB1 (AA: 1-130)-hIgGFc transfected HEK293 (2) cell lysate. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$577.50
Details
Human Kaninchen Unkonjugiert WB Observed bind size: 122KD Anti-Bub1 Picoband antibody,  All lanes: Anti BUB1  at 0.5ug/ml WB: Recombinant Human BUB1 Protein 0.5ng Predicted bind size: 39KD Observed bind size: 39KD 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert EIA, IHC (p), WB 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$484.00
Details
Maus Maus Unkonjugiert ICC, FACS, IF, IHC (p), WB 50 μL Anmelden zum Anzeigen 7 bis 8 Tage
$447.65
Details
Human Kaninchen Unkonjugiert IHC, ELISA Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using BUB1 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Anmelden zum Anzeigen 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert FACS, WB BUB1A Antibody (N-term) (ABIN651630) western blot analysis in A549 cell line lysates (35 µg/lane). This demonstrates the BUB1A antibody detected the BUB1A protein (arrow). BUB1A Antibody (N-term) (ABIN651630) flow cytometric analysis of A549 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma BUB1A Antibody (F1058) (ABIN392626) western blot analysis in T47D cell line lysates (35 µg/lane).This demonstrates the BUB1A antibody detected the BUB1A protein (arrow). 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Kaninchen Unkonjugiert ELISA, IHC, IHC (p) 100 μL Anmelden zum Anzeigen 11 bis 14 Tage
$493.17
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of BUB1 expression in mouse brain Western blot analysis of BUB1 expression in COLO205 cells,The lane on the left is treated with the antigen-specific peptide. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert ELISA, IHC ABIN6266751 at 1/100 staining human testis tissue sections by IHC-P. The tissue was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. The tissue was then blocked and incubated with the antibody for 1.5 hours at 22°C. An HRP conjugated goat anti-rabbit antibody was used as the secondary. 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$390.77
Details

Am meisten referenzierte anti-BUB1 Antikörper

  1. Human Polyclonal BUB1 Primary Antibody für ICC, ELISA - ABIN1001946 : Williams, Roberts, Gjoerup: Bub1: escapades in a cellular world. in Cell cycle (Georgetown, Tex.) 2007 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal BUB1 Primary Antibody für ICC, ELISA - ABIN1001947 : Meraldi, Sorger: A dual role for Bub1 in the spindle checkpoint and chromosome congression. in The EMBO journal 2005 (PubMed)
    Show all 4 Pubmed References

  3. Mouse (Murine) Monoclonal BUB1 Primary Antibody für ICC, FACS - ABIN108553 : Liu, Hittle, Jablonski, Campbell, Yoda, Yen: Human CENP-I specifies localization of CENP-F, MAD1 and MAD2 to kinetochores and is essential for mitosis. in Nature cell biology 2003 (PubMed)
    Show all 4 Pubmed References

  4. Mouse (Murine) Monoclonal BUB1 Primary Antibody für ICC, FACS - ABIN108554 : Qi, Tang, Yu: Phosphorylation- and polo-box-dependent binding of Plk1 to Bub1 is required for the kinetochore localization of Plk1. in Molecular biology of the cell 2006 (PubMed)
    Show all 4 Pubmed References

  5. Human Polyclonal BUB1 Primary Antibody für IHC (p), ELISA - ABIN544220 : Shichiri, Yoshinaga, Hisatomi, Sugihara, Hirata: Genetic and epigenetic inactivation of mitotic checkpoint genes hBUB1 and hBUBR1 and their relationship to survival. in Cancer research 2002 (PubMed)
    Show all 3 Pubmed References

  6. Human Polyclonal BUB1 Primary Antibody für IF, WB - ABIN541609 : Pangilinan, Li, Weaver, Lewis, Dang, Spencer: Mammalian BUB1 protein kinases: map positions and in vivo expression. in Genomics 1998 (PubMed)
    Show all 3 Pubmed References

  7. Human Monoclonal BUB1 Primary Antibody für ICC, IF - ABIN2668285 : Liu, Rattner, Jablonski, Yen: Mapping the assembly pathways that specify formation of the trilaminar kinetochore plates in human cells. in The Journal of cell biology 2006 (PubMed)

Weitere Antikörper gegen BUB1 Interaktionspartner

Human Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) Interaktionspartner

  1. The roles for the BUB3-BUB1 complex in S phase.

  2. Conserved domain 1 (CD1) in human Bub1 binds directly to Mad1 and a phosphorylation site exists in CD1 that stimulates Mad1 binding and SAC signalling.

  3. Finally, the authors show that the kinetochore localization of BUB1 and BUBR1 decreases with the age of the oocyte donors. This could contribute to oocyte aneuploidy.

  4. Small sequence differences in Bub1 and BubR1 direct Bub3 to different phosphorylated targets in the spindle assembly checkpoint signaling cascade.

  5. MiR-490-5p could regulate TGFbeta/Smad signaling pathways by inhibiting BUB1.

  6. Therefore, Mps1 promotes checkpoint activation through sequentially phosphorylating Knl1, Bub1, and Mad1. This sequential multi-target phosphorylation cascade makes the checkpoint highly responsive to Mps1 and to kinetochore-microtubule attachment.

  7. Chromosomal rearrangement resulting in BUB1 haploinsufficiency identified in a patient with polycystic liver disease. BUB1 may imply germline causes of genetic instability in PLD.

  8. Results report that BubR1 and RepoMan bind directly to PP2A-B56 using an LSPIxE short linear motif (SLiM), where phosphorylation of the Ser residue enhances binding. RepoMan and BubR1 bind B56 using both hydrophobic and electrostatic interactions.

  9. Inhibition of Bub1 kinase impaired chromosome arm resolution but exerted only minor effects on mitotic progression or spindle assembly checkpoint function.

  10. Study shows that BUB1beta and PDZ binding kinase are up-regulated in breast cancer tumors and their expression is associated with improved overall survival (OS) in basal-like tumors but worse OS in luminal and untreated patients.

  11. Bub1 may be associated with cancer stem cell potential.

  12. Both Bub1 and BubR1 bind stably to Bub3 that is required for kinetochore localization of the proteins

  13. Bub1-Plk1-mediated phosphorylation of Cdc20 constitutes an anaphase-promoting complex or cyclosome-inhibitory mechanism that is parallel, but not redundant, to mitotic checkpoint complex formation.

  14. Data show that mitotic checkpoint kinase Bub1 is an active kinase regulated by intra-molecular phosphorylation at the P+1 loop.

  15. human BUB1 does not associate stably with the MAD2 activator MAD1 (also known as MAD1L1) and, although required for accelerating the loading of MAD1 onto kinetochores, BUB1 is dispensable for the maintenance of steady-state levels of MAD1 there

  16. MAD2L1 and BUB1 may play important roles in breast cancer progression, and measuring the expression of these genes may assist the prediction of breast cancer prognosis.

  17. Data provide novel insight into the regulation and kinetochore residency of Bub1 and indicate that its localization is dynamic and tightly controlled through feedback autophosphorylation.

  18. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities.

  19. BUB1B expression was highly correlated to CDC20 and CCNB1 expression in multiple myeloma cells, leading to increased cell proliferation.Bub1 expression promotes cell proliferation and leads to poor survival in multiple myeloma patients

  20. BubR1 is a component of the Mitotic checkpoint complex and was reported to be overexpressed in Breast cancer. BubR1 overexpression was correlated with poor survival in early stage Breast cancer patients.

Mouse (Murine) Budding Uninhibited By Benzimidazoles 1 Homolog (Yeast) (BUB1) Interaktionspartner

  1. Bub1 coordinates checkpoint signalling by distinct domains for RZZ and BubR1 recruitment and localizes antagonistic checkpoint activities.

  2. It was shown that that Bub1 kinase activity integrates attachment error correction and mitotic checkpoint signaling by controlling the localization and activity of Aurora B kinase through phosphorylation of histone H2A at threonine 121.

  3. Results establish that Bub1 has oncogenic properties and suggest that Aurora B is a critical target through which overexpressed Bub1 drives aneuploidization and tumorigenesis.

  4. It seems that Sgo1 sets up the centromeric protection mechanism in G2, but that its Bub1-dependent localisation to centromeres during mitosis is not required to maintain cohesion.

  5. mutations of Bub1 and BubR1 found in Brca2- mutant mice indeed are responsible for the chromosome instability in Brca2-mutated tumors

  6. Our data suggest that Bub1 is a critical spindle checkpoint protein that regulates accurate chromosome alignment and homolog disjunction in mammalian oocyte meiosis.

  7. Bub1 is important for mediating cell death when chromosomes missegregate.

  8. Bub1 is essential for proper chromosome segregation, a defect that can lead to severe phenotypes, including perinatal lethality and a predisposition to cancer.

  9. Data show that the anaphase-promoting complex is activated in an exponential fashion after germinal vesicle breakdown in oocytes and that this process is advanced by 5 hr in oocytes lacking Bub1.

  10. Bub1 dysfunction is linked to inherited aneuploidy in female germ cells and may contribute to the maternal age-related increase in aneuploidy and pregnancy loss.

  11. Bub1 insufficiency can drive tumor formation through tumor suppressor gene loss of heterozygosity, but only in restricted genetic and cellular contexts

BUB1 Antigen-Profil

Protein Überblick

This gene encodes a kinase involved in spindle checkpoint function. The kinase functions in part by phosphorylating a member of the miotic checkpoint complex and activating the spindle checkpoint. Mutations in this gene have been associated with aneuploidy and several forms of cancer.

Genbezeichner und Symbole assoziert mit BUB1

  • BUB1 mitotic checkpoint serine/threonine kinase (BUB1) Antikörper
  • BUB1 mitotic checkpoint serine/threonine kinase (bub1) Antikörper
  • BUB1 mitotic checkpoint serine/threonine kinase (Bub1) Antikörper
  • BUB1, mitotic checkpoint serine/threonine kinase (Bub1) Antikörper
  • AL022991 Antikörper
  • Bub1a Antikörper
  • BUB1L Antikörper
  • C80208 Antikörper
  • D2Xrf87 Antikörper
  • hBUB1 Antikörper
  • xbub1 Antikörper

Bezeichner auf Proteinebene für BUB1

BUB1 budding uninhibited by benzimidazoles 1 homolog , mitotic checkpoint serine/threonine-protein kinase BUB1 , budding uninhibited by benzimidazoles 1 , budding uninhibited by benzimidazoles 1 homolog , mitotic spindle checkpoint kinase , putative serine/threonine-protein kinase , mBUB1

GENE ID SPEZIES
100064049 Equus caballus
459484 Pan troglodytes
780291 Xenopus (Silurana) tropicalis
699 Homo sapiens
296137 Rattus norvegicus
12235 Mus musculus
100682599 Canis lupus familiaris
514777 Bos taurus
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