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anti-Mouse (Murine) PARK7 Antikörper:
anti-Human PARK7 Antikörper:
anti-Rat (Rattus) PARK7 Antikörper:
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Chicken Polyclonal PARK7 Primary Antibody für ICC, IF - ABIN152611
Jin, Li, Davis, Zhu, Wang, Pan, Zhang: Identification of novel proteins associated with both alpha-synuclein and DJ-1. in Molecular & cellular proteomics : MCP 2007
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Human Polyclonal PARK7 Primary Antibody für ELISA, WB - ABIN249806
Ooe, Taira, Iguchi-Ariga, Ariga: Induction of reactive oxygen species by bisphenol A and abrogation of bisphenol A-induced cell injury by DJ-1. in Toxicological sciences : an official journal of the Society of Toxicology 2005
Show all 7 Pubmed References
Human Polyclonal PARK7 Primary Antibody für ICC, IF - ABIN151929
Hong, Shi, Chung, Quinn, Peskind, Galasko, Jankovic, Zabetian, Leverenz, Baird, Montine, Hancock, Hwang, Pan, Bradner, Kang, Jensen, Zhang: DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. in Brain : a journal of neurology 2010
Show all 4 Pubmed References
Human Monoclonal PARK7 Primary Antibody für ICC, IHC (fro) - ABIN335354
Bonné, Gilbert, Hatzfeld, Chen, Green, van Roy: Defining desmosomal plakophilin-3 interactions. in The Journal of cell biology 2003
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Zebrafish (Danio rerio) Polyclonal PARK7 Primary Antibody für WB - ABIN1881625
Bai, Mullett, Garver, Hinkle, Burton: Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons. in Brain research 2006
Show all 2 Pubmed References
Human Polyclonal PARK7 Primary Antibody für ELISA, WB - ABIN564912
Morrison, Thompson, Williamson, Cheetham, Robinson: A simple cell based assay to measure Parkin activity. in Journal of neurochemistry 2011
Human Polyclonal PARK7 Primary Antibody für WB - ABIN524725
Donadio, Giusti, Cetani, Da Valle, Ciregia, Giannaccini, Pardi, Saponaro, Torregrossa, Basolo, Marcocci, Lucacchini: Evaluation of formalin-fixed paraffin-embedded tissues in the proteomic analysis of parathyroid glands. in Proteome science 2011
Cow (Bovine) Monoclonal PARK7 Primary Antibody für ICC, IF - ABIN4343700
Wang, Fang, Zhang, Li, Guan, Sun, Xie, Zhong: The positive correlation between DJ-1 and β-catenin expression shows prognostic value for patients with glioma. in Neuropathology : official journal of the Japanese Society of Neuropathology 2013
Melatonin, added together with MPTP (zeige PTPN2 Antikörper) or added once MPTP (zeige PTPN2 Antikörper) was removed, prevented and recovered, respectively, the parkinsonian phenotype once it was established, restoring gene expression and normal function of the parkin (zeige PARK2 Antikörper)/PINK1 (zeige PINK1 Antikörper)/DJ-1/MUL1 loop and also the normal motor activity of the embryos.
These studies show that zDJ-1 is very similar to human DJ-1 and is evolutionarily conserved and expressed in dopaminergic neurons.
chaperone-mediated autophagy protects mitochondrial function by degrading nonfunctional PARK7 and maintaining its homeostasis, and dysregulation of this pathway may contribute to the neuronal stress and death in Parkinson disease pathogenesis
Knockdown of DJ-1 attenuates Nurr1 (zeige NR4A2 Antikörper) activity.
These results demonstrate that DJ-1 KO mice display progressive signs of retinal/RPE (zeige RPE Antikörper) degeneration in association with higher levels of oxidative stress markers. Collectively this analysis indicates that DJ-1 plays an important role in protecting photoreceptors and RPE (zeige RPE Antikörper) from oxidative damage during aging
DJ-1 activates autophagy to alleviate cardiac hypertrophy.
These results indicate that up-regulation of GH in the lungs of DJ-1 KO mice may enhance the malignancy of B16F10 cells and nodule formation in pulmonary metastasis of melanoma.
DJ-1 is a powerful regulator of reactive oxygen species production as well as NHE1 (zeige SLC9A1 Antikörper) expression and activity in CD4 (zeige CD4 Antikörper)(+) T cells.
DJ-1 deficiency negatively regulates liver progenitor cells (LPC (zeige PCSK7 Antikörper)) proliferation by impairing the formation of LPC (zeige PCSK7 Antikörper)-associated fibrosis and inflammatory niches.
regulation of reactive oxygen species (ROS (zeige ROS1 Antikörper)) and of the antioxidant protein (zeige PRDX3 Antikörper) DJ-1 (PARK-7), which increases with cancer progression and acts to lessen oxidative damage to malignant cells, in relationship with systemic mastocytosis severity, was examined.
Our data strengthen previous findings regarding DJ-1 diverse pathways and indicate that DJ-1 is part of a concerted and complex cellular response to OS
Our data demonstrates that the activation of DJ-1 in response to myocardial I/R injury protects the heart by regulating the SUMOylation status of Drp1 (zeige CRMP1 Antikörper) and attenuating excessive mitochondrial fission.
DJ-1 and its prokaryotic homologs constitute a major nucleotide repair system named guanine glycation repair.
Taken together, our results provide a structural basis for the binding mechanism between DJ-1 and Bcl-XL (zeige BCL2L1 Antikörper), which will contribute to molecular understanding of the role of mitochondrial DJ-1 in Bcl-XL (zeige BCL2L1 Antikörper) regulation in response to oxidative stress.
Results suggest that overexpression of DJ-1 improves mitochondrial function, at least in part, through a mechanism involving Akt (zeige AKT1 Antikörper) phosphorylation on threonine 308.
Hsp31 is a homodimeric protein structurally similar to human DJ-1, a Parkinson's disease-linked protein, and both are members of the DJ-1/ThiJ/PfpI superfamily.
DJ-1 co-aggregating with alpha-synuclein may result from weak hydrophobic interaction and DJ-1 exhibited chaperon-like activity in the initial time of alpha-synuclein aggregation at high temperature.
The effects of variants in the Parkin (zeige PARK2 Antikörper), PINK1 (zeige PINK1 Antikörper), and DJ-1 genes along with evidence for their pathogenicity have been summarized. (Review)
genetic analyses of indel loci in ACE (zeige ACE Antikörper), DJ-1, and GIGYF2 (zeige GIGYF2 Antikörper) genes, was performed to explore the potential contribution of insertion (I)/deletion (D) polymorphisms (indels) to the risk of PD in a Chinese population.
Downregulation of DJ-1 using DJ-1-siRNA in H69AR cells sensitized cancer cells to chemotherapeutic drugs through increasing drug-induced cell apoptosis accompanied with G0-G1 phase arrest. These findings suggest DJ-1 may serve as a potential biomarker for chemoresistance and prognostic factor for patients with small-cell lung cancer (SCLC).
The PARK7 gene was demonstrated to be located on porcine chromosome 6
The product of this gene belongs to the peptidase C56 family of proteins. It acts as a positive regulator of androgen receptor-dependent transcription. It may also function as a redox-sensitive chaperone, as a sensor for oxidative stress, and it apparently protects neurons against oxidative stress and cell death. Defects in this gene are the cause of autosomal recessive early-onset Parkinson disease 7. Two transcript variants encoding the same protein have been identified for this gene.
, parkinson disease protein 7 homolog
, protein DJ-1
, Parkinson disease 7
, RNA-binding protein regulatory subunit
, Parkinson disease (autosomal recessive, early onset) 7
, oncogene DJ1
, contraception-associated protein 1
, fertility protein SP22