MAP2K3 Antikörper (C-Term)

Produktnummer ABIN966513

Produktdetails anti-MAP2K3 Antikörper

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Bindungsspezifität: AA 320-334, C-Term

Reaktivität: Human, Ratte

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser MAP2K3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human MAP2K3 (320-334 aa), identical to the related mouse and rat sequence.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: 0.2ml of distilled water will yield a concentration of 500µg/ml.

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-MAP2K3 Antikörper (ABIN966513)

Rampoldi, Zimbello, Bortoluzzi, Tiso, Valle, Lanfranchi, Danieli: "Chromosomal localization of four MAPK signaling cascade genes: MEK1, MEK3, MEK4 and MEKK5." in: Cytogenetics and cell genetics, Vol. 78, Issue 3-4, pp. 301-3, (1998) (PubMed).

Details zu MAP2K3

Target: MAP2K3 (Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))

Andere Bezeichnung: MAP2K3 (MAP2K3 Produkte)

Synonyme: MAPKK3 antikoerper, MEK3 antikoerper, MKK3 antikoerper, PRKMK3 antikoerper, SAPKK-2 antikoerper, SAPKK2 antikoerper, AW212142 antikoerper, Prkmk3 antikoerper, mMKK3b antikoerper, Mkk3 antikoerper, mitogen-activated protein kinase kinase 3 antikoerper, mitogen activated protein kinase kinase 3 antikoerper, MAP kinase activator XMEK3 antikoerper, MAP2K3 antikoerper, Map2k3 antikoerper, map2k3 antikoerper

Hintergrund: Dual specificity mitogen-activated protein kinase kinase 3 is an enzyme that in humans is encoded by the MAP2K3 gene. The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. Rampoldi et al. (1997) localized the MAP2K3 gene to 17q11.2.

Pathways: MAPK Signalweg, TLR Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Autophagie, Signaling Events mediated by VEGFR1 and VEGFR2