MAP2K3 Produkte
(Mitogen-Activated Protein Kinase Kinase 3 (MAP2K3))
Kategorien
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008].
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Ausgewählte MAP2K3 Kategorien
MAP2K3 Antikörper
High quality antibodies with extensive validation data.
MAP2K3 ELISA Kits
Reliable ELISA kits for a wide range of species.
MAP2K3 Proteine
Proteins for various applications incl. WB, ELISA, IF etc.
Empfohlene MAP2K3 Antikörper
Produkt
Reaktivität
Applikation
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, IF
Validierungen
- (1)
- (7)
Kat. Nr.
ABIN6143484
Menge
100 μL
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Applikation
IHC, IF
Validierungen
- (6)
Kat. Nr.
ABIN7263723
Menge
200 μL
Datenblatt
Datenblatt
Reaktivität
Human
Applikation
WB, IHC, ELISA, ICC, FACS
Validierungen
- (9)
Kat. Nr.
ABIN5542528
Menge
0.1 mg
Datenblatt
Datenblatt
Empfohlene MAP2K3 ELISA Kits
Produkt
Reaktivität
Analytical Method
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Cell ELISA
Validierungen
Kat. Nr.
ABIN4881290
Menge
96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validierungen
Kat. Nr.
ABIN1380776
Menge
2 x 96 tests
Datenblatt
Datenblatt
Reaktivität
Human, Mouse, Rat
Analytical Method
Semi-Quantitative Sandwich ELISA
Validierungen
Kat. Nr.
ABIN2748359
Menge
96 tests
Datenblatt
Datenblatt
Empfohlene MAP2K3 Proteine
Produkt
Reaktivität
Source
Validierungen
Kat. Nr.
Menge
Datenblatt
Reaktivität
Human
Source
Insect cells (Sf21)
Validierungen
- (2)
Kat. Nr.
ABIN5570489
Menge
5 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Escherichia coli (E. coli)
Validierungen
- (1)
Kat. Nr.
ABIN7124000
Menge
50 μg
Datenblatt
Datenblatt
Reaktivität
Human
Source
Wheat germ
Validierungen
- (1)
Kat. Nr.
ABIN1310177
Menge
10 μg
Datenblatt
Datenblatt
Neueste Publikationen zu unseren MAP2K3 Produkten
: "Silencing Ras-Related C3 Botulinum Toxin Substrate 1 Inhibits Growth and Migration of Hypopharyngeal Squamous Cell Carcinoma via the P38 Mitogen-Activated Protein Kinase Signaling Pathway." in: Medical science monitor : international medical journal of experimental and clinical research, Vol. 24, pp. 768-781, (2018) (PubMed).: "MAPK kinase 10.2 promotes disease resistance and drought tolerance by activating different MAPKs in rice." in: The Plant journal : for cell and molecular biology, Vol. 92, Issue 4, pp. 557-570, (2018) (PubMed).
: "MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3." in: BMC cancer, Vol. 13, pp. 469, (2013) (PubMed).
: "MAP2K3 is associated with body mass index in American Indians and Caucasians and may mediate hypothalamic inflammation." in: Human molecular genetics, Vol. 22, Issue 21, pp. 4438-49, (2013) (PubMed).
: "MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival." in: Molecular cancer therapeutics, Vol. 6, Issue 4, pp. 1212-22, (2007) (PubMed).
: "Cytokine activation of p38 mitogen-activated protein kinase and apoptosis is opposed by alpha-4 targeting of protein phosphatase 2A for site-specific dephosphorylation of MEK3." in: Molecular and cellular biology, Vol. 27, Issue 12, pp. 4217-27, (2007) (PubMed).
: "The survival kinase Mirk/dyrk1B is activated through Rac1-MKK3 signaling." in: The Journal of biological chemistry, Vol. 280, Issue 51, pp. 42097-105, (2005) (PubMed).
: "Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase ..." in: Molecular biology of the cell, Vol. 14, Issue 2, pp. 529-44, (2003) (PubMed).
: "Comparative studies of a new subfamily of human Ste20-like kinases: homodimerization, subcellular localization, and selective activation of MKK3 and p38." in: Oncogene, Vol. 22, Issue 40, pp. 6129-41, (2003) (PubMed).
Synonyme und alternative Namen zu MAP2K3
mitogen-activated protein kinase kinase 3 (MAP2K3), mitogen-activated protein kinase kinase 3 (Map2k3), mitogen activated protein kinase kinase 3 (Map2k3), MAP kinase activator XMEK3 (map2k3), AW212142, MAPKK3, MEK3, MKK3, Mkk3, mMKK3b, PRKMK3, Prkmk3, SAPKK-2, SAPKK2Bezeichner auf Proteinebene für MAP2K3
- MAP kinase kinase 3
- MAPK/ERK kinase 3
- MAPKK 3
- MEK 3
- SAPK kinase 2
- dual specificity mitogen-activated protein kinase kinase 3
- stress-activated protein kinase kinase 2
- mitogen activated protein kinase kinase 3
- protein kinase, mitogen-activated, kinase 3
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