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CD130/gp130 Antikörper
IL6ST
Reaktivität: Human
FACS
Wirt: Maus
Monoclonal
B-R3
unconjugated
Produktnummer ABIN1105851
Produktdetails anti-CD130/gp130 Antikörper
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Target
Alle CD130/gp130 (IL6ST) Antikörper anzeigen
CD130/gp130 (IL6ST)
(Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
Reaktivität
Alle Reaktivitäten für CD130/gp130 Antikörper
Human
Wirt
Alle Wirte für CD130/gp130 Antikörper
Maus
Klonalität
Alle Klonalitäten für CD130/gp130 Antikörper
Monoklonal
Konjugat
Alle Konjugate für CD130/gp130 Antikörper
Dieser CD130/gp130 Antikörper ist unkonjugiert
Applikation
Alle Applikationen für CD130/gp130 Antikörper
Flow Cytometry (FACS)
Spezifität
Recognises the Gp130, common subunit for IL-6, IL-11, OSM, LIF, CNTF, CT-1 receptors, a 130-140 kDa protein.
Kreuzreaktivität (Details)
Species reactivity (tested):Human.
Aufreinigung
Ion Exchange Chromatography
Immunogen
Natural soluble gp130.
Klon
B-R3
Isotyp
IgG2a
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Anwendungsinformationen
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Applikationshinweise
Optimal working dilution should be determined by the investigator.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Handhabung
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Format
Liquid
Buffer
PBS containing 0.09 % Sodium Azide as preservative and 1 % BSA as stabilizer
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C
Informationen zur Lagerung
Store the antibody undiluted at 2-8 °C.
Details zu CD130/gp130
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Target
CD130/gp130 (IL6ST)
(Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST))
Andere Bezeichnung
CD130 / IL6ST (IL6ST Produkte )
Synonyme
CD130 antikoerper, CDW130 antikoerper, GP130 antikoerper, IL-6RB antikoerper, 5133400A03Rik antikoerper, AA389424 antikoerper, BB405851 antikoerper, D13Ertd699e antikoerper, gp130 antikoerper, Ac1055 antikoerper, Gp130 antikoerper, Il-6rb antikoerper, IL-6 antikoerper, interleukin 6 signal transducer antikoerper, IL6ST antikoerper, Il6st antikoerper, il6st antikoerper
Hintergrund
CD130 is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gen-ID
3572
NCBI Accession
NP_002175
UniProt
P40189
Pathways
JAK-STAT Signalweg , Cellular Glucan Metabolic Process , Autophagie , Smooth Muscle Cell Migration , Cancer Immune Checkpoints
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