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Plk1 inhibition (RNAi, pharmacological compounds) promotes the development of adenomatous polyps in two independent Apc (Min/+) mouse models.
APC defines Treg differentiation and anti-inflammatory function through microtubule-mediated NFAT (zeige NFATC1 Proteine) localization.
In summary, we show that Pten loss per se in Lgr5 (zeige LGR5 Proteine)+ intestinal stem cells is not required either as a tumor suppressor or for maintaining intestinal homeostasis when Apc is functional, even when combined with obesity.
In this study, the effect of deficiency of OPN (zeige SPP1 Proteine) on intestinal tumor development in Apc-deficient Min mice was investigated.At 16 weeks of age, the number of small intestinal polyps in Min/OPN (zeige SPP1 Proteine)(+/-) and Min/OPN (zeige SPP1 Proteine)(-/-) mice was lower than that of Min/OPN (zeige SPP1 Proteine)(+/+) mice. Colorectal tumor incidences and multiplicities in Min/OPN (zeige SPP1 Proteine)(+/-) and Min/OPN (zeige SPP1 Proteine)(-/-) mice were significantly lower than those in Min/OPN (zeige SPP1 Proteine)(+/+) mice
The results indicate that C-terminal domain of APC has a role in the regulation of intestinal epithelium homeostasis.
Neonatal APC conditional knock-out (cKO) mice exhibit flexion-extension motor spasms and abnormal high-amplitude electroencephalographic discharges. Frequency of excitatory postsynaptic currents is increased in layer V pyramidal cells. At adult ages, APC cKOs display spontaneous electroclinical seizures. APC cKO is a new genetic model of infantile spasms.
we provide mechanistic insight into the role of APC mutations and Wnt (zeige WNT2 Proteine) signaling in hematopoietic stem cells (HSC (zeige FUT1 Proteine)) biology. As Wnt (zeige WNT2 Proteine) signals are explored in various in vivo and ex vivo expansion protocols for HSCs, our findings also have clinical ramifications.
The results reveal that APC-regulated beta-catenin (zeige CTNNB1 Proteine) activity in cortical progenitors sets the appropriate Wnt (zeige WNT2 Proteine) tone necessary for normal cerebral cortical development.
Dll4 (zeige DLL4 Proteine) seems to promote Apc (Min/+) tumorigenesis.
In cancer-prone, heterozygous APC mutant mice, homozygous deletion of the Rad52 (zeige RAD52 Proteine) gene suppressed tumor growth and prolonged lifespan.
Because of low sensitivity, APC gene promoter methylation in serum was not suitable for breast cancer (BC) screening. However, as specificity was very high, detection of serum APC gene promoter methylation could be used as tool to confirm BC.
Multivariate analyses revealed that the PIK3CA (zeige PIK3CA Proteine) mutation and clinical T stage were independent favorable prognostic factors (hazard ratio 0.34, 95% confidence interval: 0.12-0.96, p = 0.042). PIK3CA (zeige PIK3CA Proteine) mutations were significantly associated with APC alterations (p = 0.0007) and BRAF (zeige BRAF Proteine) mutations (p = 0.0090).
A novel APC frameshift mutation has been identified in a large Chinese family with familial adenomatous polyposis.
In the two wild type (WT) cases, two novel alterations were detected: a complex deletion of APC and a pathogenic mutation of LAMTOR2 (zeige LAMTOR2 Proteine). Focusing on WT DT subtype, deep sequencing of CTNNB1 (zeige CTNNB1 Proteine), APC and LAMTOR2 (zeige LAMTOR2 Proteine) was conducted on a retrospective series of 11 WT DT using a targeted approach
This study demonstrates a prognostic role for APC.
There is a certain correlation between the APC gene and ovarian tumors, and the APC gene mediates the apoptosis of tumor cells through the MDR-1/CLCX-1 signaling pathway.
We have investigated if the initial source of intratumoral heterogeneity is consequent to multiple independent lineages derived from different crypts harboring distinct truncal APC and driver KRAS mutations, thus challenging the prevailing monoclonal monocryptal model.
methylation-dependent silencing of the APC gene promoter 1A is a mechanism that contributes to the activation of Wnt (zeige WNT2 Proteine) signaling pathway in cervical cancer cells infected by high risk HPV16.
miR (zeige MLXIP Proteine)-3607 contributes to lung cancer cell proliferation by inhibiting APC.
USP7 (zeige USP7 Proteine) depletion in APC-mutated colorectal cancer inhibits Wnt (zeige WNT2 Proteine) activation by restoring beta-catenin (zeige CTNNB1 Proteine) ubiquitination, drives differentiation, and suppresses xenograft tumor growth.
the Amer2 (zeige AMER2 Proteine)-EB1 (zeige MAPRE1 Proteine)-APC complex regulates cell migration by altering microtubule stability.
Data show that importin-beta (zeige KPNB1 Proteine) binds to Apc and negatively regulates the MT-assembly and spindle-promoting activity of Apc in a Ran-regulatable manner.
APC and Axin (zeige AXIN1 Proteine) are involved in the Wnt (zeige WNT2 Proteine) pathway
depletion of APC from cystostatic factor (CSF (zeige CSF2 Proteine)) Xenopus extracts leads to a decrease in microtubule density and changes in tubulin (zeige TUBB Proteine) distribution in spindles and asters formed in such extracts
An interaction of tumor-associated N-terminal APC fragments (N-APC) with Mad2 (zeige MAD2L1 Proteine), an essential mitotic checkpoint (zeige BUB3 Proteine) protein, providing a direct molecular support for linking APC mutations to the generation of chromosome instability, is reported.
This gene encodes a tumor suppressor protein that acts as an antagonist of the Wnt signaling pathway. It is also involved in other processes including cell migration and adhesion, transcriptional activation, and apoptosis. Defects in this gene cause familial adenomatous polyposis (FAP), an autosomal dominant pre-malignant disease that usually progresses to malignancy. Disease-associated mutations tend to be clustered in a small region designated the mutation cluster region (MCR) and result in a truncated protein product.
adenomatosis polyposis coli
, adenomatous polyposis coli protein
, multiple intestinal neoplasia
, adenomatosis polyposis coli tumor suppressor
, deleted in polyposis 2.5
, protein phosphatase 1, regulatory subunit 46
, adenomatous polyposis coli homolog