anti-Hund TLR3 Antikörper für Functional Studies

Recommended TLR3 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Toll-Like Receptor 3 (TLR3) Antikörper
  • CD283
  • IIAE2
  • AI957183
  • zgc:123006
  • toll like receptor 3
  • toll-like receptor 3
  • TLR3
  • Tlr3
  • tlr3
Reaktivität
Hund, Human, Maus
276
206
64
44
5
4
3
2
2
2
1
1
1
1
1
Wirt
Maus
198
119
39
3
3
Klonalität
Monoklonal
Konjugat
Dieser TLR3 Antikörper ist konjugiert mit FITC
34
29
24
16
10
8
7
6
4
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Applikation
Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
234
140
103
89
64
42
40
33
13
13
12
7
4
4
1
1
Hersteller
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Hersteller Produkt- Nr.
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Mehr erfahren

Produktnummer ABIN1106214
$ 489.50
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN1106212 Func IHC (fro) FACS IF IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen TLR3-7 5
1 ABIN1106213 Func IHC (fro) IF IHC (p) IP WB Biotin Mouse IgG1 Anmelden zum Anzeigen TLR3-7 4

General

Antigen Toll-Like Receptor 3 (TLR3) Antikörper
Reaktivität Hund, Human, Maus
(276), (206), (64), (44), (5), (4), (3), (2), (2), (2), (1), (1), (1), (1), (1)
Wirt Maus
(198), (119), (39), (3), (3)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TLR3 Antikörper ist konjugiert mit FITC
(34), (29), (24), (16), (10), (8), (7), (6), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(234), (140), (103), (89), (64), (42), (40), (33), (13), (13), (12), (7), (4), (4), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TLR3 Antikörper

Target Details TLR3 Anwendungsinformationen Handhabung Referenzen für anti-TLR3 Antikörper (ABIN1106214) Bilder
Spezifität The monoclonal antibody TLR3.7 recognizes the 116 kDa human Toll-like receptor 3 (TLR3, CD283).
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse, canine
Reinigung Protein G
Immunogen Human Flag-tagged TLR3 stably expressed by Ba/F3 cells
Klon TLR3-7
Isotyp IgG1
Plasmids, Primers & others

Target Details TLR3

Produktdetails anti-TLR3 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TLR3 Antikörper (ABIN1106214) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD283 / TLR3 (TLR3 Antibody Abstract)
Hintergrund Toll-like receptors (TLRs) are highly conserved from Drosophila to humans and share structural and functional similarities. TLRs constitute of a family of pattern recognition receptors (PRRs) that mediate cellular responses to a large variety of pathogens (viruses, bacteria, and parasites) by specific recognition of so-called 'pathogen-associated molecular patterns'. Activation of TLRs, a family of at least 11 different members that function either as homo- or heterodimers, leads to activation of NFκB-dependent and IFN-regulatory factor-dependent signaling pathways. TLRs have a central role in innate immunity and are also required for the development of an adaptive immune response. TLRs are expressed by various cells of the immune system, such as macrophages and dendritic cells. TLRs are class I receptors, with a single α-helix that spans the cell membrane. They recognize and respond to molecules derived from bacterial, viral and fungal pathogens, such as lipopolysaccharide (LPS) from the outer membrane of Gram negative bacteria, peptidoglycan fragments from bacterial cell walls and single-stranded and double-stranded RNA from viruses. Some forms of RNA and DNA from pathogens exhibit immutable features that distinguish them from nucleic acids of higher organisms. For example, dsRNA, is a common intermediate of viral replication and a potent indicator of infection. Toll-like receptor 3 (TLR3) recognizes viral double-stranded RNA and its synthetic analog polyriboinosinic:polyribocytidylic acid (poly(I:C)). TLR3 is normally located in acidic endosomes where its luminal ectodomain (ECD) encounters dsRNA and induces type I interferon (IFN), inflammatory cytokine/chemokine production and dendritic cell (DC) maturation via the adaptor protein TICAM-1 (also called TRIF). Based on the different subcellular localization of cytosolic RNA receptors and TLR3, these receptors seem to play distinct roles in anti-viral immune responses.Synonyms: Toll-like receptor 3
Gen-ID 7098
NCBI Accession NP_003256
UniProt O15455
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Handhabung Referenzen für anti-TLR3 Antikörper (ABIN1106214) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Anwendungsinformationen Referenzen für anti-TLR3 Antikörper (ABIN1106214) Bilder zurück nach oben
Konzentration 0.1 mg/mL
Buffer PBS, 0.02 % sodium azide, 1 % bovine serum albumin
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung 4 °C
Informationen zur Lagerung Store at 2 - 8 °C.

Referenzen für anti-TLR3 Antikörper (ABIN1106214)

Produktdetails anti-TLR3 Antikörper Target Details TLR3 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Burgener, Jungi: "Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry." in: Veterinary immunology and immunopathology, Vol. 124, Issue 1-2, pp. 184-91, 2008

Oshiumi, Matsumoto, Funami, Akazawa, Seya: "TICAM-1, an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction." in: Nature immunology, Vol. 4, Issue 2, pp. 161-7, 2003

Matsumoto, Funami, Tanabe, Oshiumi, Shingai, Seto, Yamamoto, Seya: "Subcellular localization of Toll-like receptor 3 in human dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 6, pp. 3154-62, 2003

Matsumoto, Kikkawa, Kohase, Miyake, Seya: "Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling." in: Biochemical and biophysical research communications, Vol. 293, Issue 5, pp. 1364-9, 2002