anti-Ratte (Rattus) TAB1 Antikörper für ELISA

Recommended TAB1 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) Antikörper
  • 3'-Tab1
  • MAP3K7IP1
  • 2310012M03Rik
  • Map3k7ip1
  • b2b449Clo
  • TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  • TGF-beta activated kinase 1/MAP3K7 binding protein 1
  • TAB1
  • Tab1
Epitop
AA 3-101
31
11
10
10
9
9
8
6
6
5
5
3
2
2
2
2
2
2
1
1
1
1
1
1
Reaktivität
Human, Ratte (Rattus)
184
83
63
8
6
5
4
3
3
2
1
1
1
1
Wirt
Maus
158
24
2
Klonalität
Monoklonal
Konjugat
Dieser TAB1 Antikörper ist unkonjugiert
9
9
8
6
6
6
3
2
2
2
2
2
2
2
2
2
2
Applikation
ELISA, Immunofluorescence (IF), Western Blotting (WB)
133
77
27
22
18
14
12
11
9
3
3
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN393549
$ 461.00
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN333172 ELISA WB Mouse IgG2a, kappa Anmelden zum Anzeigen 0
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1 ABIN6263110 ELISA IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2423759 IHC ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2938482 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN5703251 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2430413 IHC ELISA Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1088863 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN5923315 ELISA WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN1579785 ELISA WB Mouse Anmelden zum Anzeigen 0

General

Antigen TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) Antikörper
Epitop AA 3-101
(31), (11), (10), (10), (9), (9), (8), (6), (6), (5), (5), (3), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Ratte (Rattus)
(184), (83), (63), (8), (6), (5), (4), (3), (3), (2), (1), (1), (1), (1)
Wirt Maus
(158), (24), (2)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser TAB1 Antikörper ist unkonjugiert
(9), (9), (8), (6), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Applikation ELISA, Immunofluorescence (IF), Western Blotting (WB)
(133), (77), (27), (22), (18), (14), (12), (11), (9), (3), (3), (2), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-TAB1 Antikörper

Target Details TAB1 Anwendungsinformationen Handhabung Referenzen für anti-TAB1 Antikörper (ABIN393549) Bilder
Spezifität MAP3K7IP1 (NP_705717, 3 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Kreuzreaktivität (Details) Human: ~~ Positive
Reinigung This antibody is purified through a protein G column, eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
Immunogen

Antigen Type: Recombinant Protein

Target/Specificity: MAP3K7IP1 (NP_705717.1, 3 a.a. ~ 100 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Klon 2A12
Isotyp IgG1 kappa
Plasmids, Primers & others

Target Details TAB1

Produktdetails anti-TAB1 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-TAB1 Antikörper (ABIN393549) Bilder zurück nach oben
Antigen
Andere Bezeichnung MAP3K7IP1 (TAB1 Antibody Abstract)
Hintergrund

Other Names: TGF-beta-activated kinase 1 and MAP3K7-binding protein 1, Mitogen-activated protein kinase kinase kinase 7-interacting protein 1, TGF-beta-activated kinase 1-binding protein 1, TAK1-binding protein 1, TAB1, MAP3K7IP1

Gene Description: mitogen-activated protein kinase kinase kinase 7 interacting protein 1

Gene Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq

Molekulargewicht 54644 DA
Gen-ID 10454
NCBI Accession NP_705717, NP_006107
UniProt Q15750
Pathways TLR Signalweg, Fc-epsilon Rezeptor Signalübertragung, Activation of Innate immune Response, Toll-Like Receptors Cascades

Anwendungsinformationen

Produktdetails anti-TAB1 Antikörper Target Details TAB1 Handhabung Referenzen für anti-TAB1 Antikörper (ABIN393549) Bilder zurück nach oben
Applikations-hinweise Western blot = 1:500-1000
Kommentare

Background: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-TAB1 Antikörper Target Details TAB1 Anwendungsinformationen Referenzen für anti-TAB1 Antikörper (ABIN393549) Bilder zurück nach oben
Konzentration 0.41 mg/mL
Buffer Clear, colorless solution in phosphate buffered saline,  pH 7.2 .
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
Haltbarkeit 6 months

Referenzen für anti-TAB1 Antikörper (ABIN393549)

Produktdetails anti-TAB1 Antikörper Target Details TAB1 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

McGovern, Jones, Taylor, Marciante, Yan, Dubinsky, Ippoliti, Vasiliauskas, Berel, Derkowski, Dutridge, Fleshner, Shih, Melmed, Mengesha, King, Pressman, Haritunians, Guo, Targan, Rotter: "Fucosyltransferase 2 (FUT2) non-secretor status is associated with Crohn's disease." in: Human molecular genetics, Vol. 19, Issue 17, pp. 3468-76, 2010

Scholz, Sidler, Thali, Winssinger, Cheung, Neumann: "Autoactivation of transforming growth factor beta-activated kinase 1 is a sequential bimolecular process." in: The Journal of biological chemistry, Vol. 285, Issue 33, pp. 25753-66, 2010

Potter, Cordell, Barton, Daly, Hyrich, Mann, Morgan, Wilson, Isaacs: "Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NF{kappa}B signalling pathways." in: Annals of the rheumatic diseases, Vol. 69, Issue 7, pp. 1315-20, 2010

Crawford, Yang, Mattaini, Hunter: "The metastasis efficiency modifier ribosomal RNA processing 1 homolog B (RRP1B) is a chromatin-associated factor." in: The Journal of biological chemistry, Vol. 284, Issue 42, pp. 28660-73, 2009

Isono, Kim, Ando, Sakurai, Okada, Inoue: "Suppression of cell invasiveness by periostin via TAB1/TAK1." in: International journal of oncology, Vol. 35, Issue 2, pp. 425-32, 2009

Bilder

Produktdetails anti-TAB1 Antikörper Target Details TAB1 Anwendungsinformationen Handhabung Referenzen für anti-TAB1 Antikörper (ABIN393549) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) Immunofluorescence of monoclonal antibody to MAP3K7IP1 on HeLa cell (antibody concent...
Immunohistochemistry (IHC) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (Image 2)
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) Antibody Reactive Against Recombinant Protein.Western Blot detection against Immunoge...
Western Blotting (WB) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) MAP3K7IP1 monoclonal antibody (M03), clone 2A12 Western Blot analysis of MAP3K7IP1 ex...
Immunofluorescence (IF) image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) Immunofluorescence of monoclonal antibody to MAP3K7IP1 on HeLa cell. [antibody concen...
ELISA image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) Detection limit for recombinant GST tagged MAP3K7IP1 is approximately 0.3ng/ml as a c...
 image for anti-TGF-beta Activated Kinase 1/MAP3K7 Binding Protein 1 (TAB1) (AA 3-101) antibody (ABIN393549) Proximity Ligation Analysis of protein-protein interactions between HSPA1L and MAP3K7...