anti-Human IRF7 Antikörper für Flow Cytometry

Recommended IRF7 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interferon Regulatory Factor 7 (IRF7) Antikörper
  • wu:fl24c03
  • zgc:66043
  • zgc:77947
  • IRF7
  • irf7
  • IRF-7H
  • IRF7A
  • IRF7B
  • IRF7C
  • IRF7H
  • interferon regulatory factor 7
  • irf7
  • IRF7
  • Irf7
Reaktivität
Human
154
60
56
3
3
3
2
2
2
1
1
Wirt
Maus
109
45
Klonalität
Monoklonal
Konjugat
Dieser IRF7 Antikörper ist konjugiert mit PE
7
6
6
6
6
6
3
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Flow Cytometry (FACS)
109
55
27
26
26
9
6
5
4
2
2
1
1
1
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2662771
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
13.774395 ABIN2657088 FACS Alexa Fluor 488 Mouse IgG2b kappa Anmelden zum Anzeigen 12G9A36 6
13.774395 ABIN2657216 FACS Alexa Fluor 647 Mouse IgG2b kappa Anmelden zum Anzeigen 12G9A36 6
1 ABIN5946619 FACS ICC IF IHC IHC (p) IP WB Rabbit IgG Anmelden zum Anzeigen SC0617 0
1 ABIN2736992 FACS IP WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN3020651 FACS IP WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0
1 ABIN2662772 FACS PE Mouse IgG2b kappa Anmelden zum Anzeigen 12G9A36 6
1 ABIN2657089 FACS Alexa Fluor 488 Mouse IgG2b kappa Anmelden zum Anzeigen 12G9A36 6
1 ABIN2657217 FACS Alexa Fluor 647 Mouse IgG2b kappa Anmelden zum Anzeigen 12G9A36 6
1 ABIN2697791 FACS IP WB Rabbit IgG Anmelden zum Anzeigen Polyclonal 0

General

Antigen Interferon Regulatory Factor 7 (IRF7) Antikörper
Reaktivität Human
(154), (60), (56), (3), (3), (3), (2), (2), (2), (1), (1)
Wirt Maus
(109), (45)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IRF7 Antikörper ist konjugiert mit PE
(7), (6), (6), (6), (6), (6), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS)
(109), (55), (27), (26), (26), (9), (6), (5), (4), (2), (2), (1), (1), (1)
Pubmed 6 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IRF7 Antikörper

Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN2662771) Bilder
Reinigung The antibody was purified by affinity chromatography and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.
Klon 12G9A36
Isotyp IgG2b kappa
Plasmids, Primers & others

Target Details IRF7

Produktdetails anti-IRF7 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN2662771) Bilder zurück nach oben
Antigen
Andere Bezeichnung IRF7 (IRF7 Antibody Abstract)
Hintergrund IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection.
Pathways TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie

Anwendungsinformationen

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Handhabung Referenzen für anti-IRF7 Antikörper (ABIN2662771) Bilder zurück nach oben
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Referenzen für anti-IRF7 Antikörper (ABIN2662771) Bilder zurück nach oben
Buffer Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide and 0.2 % (w/v) BSA .
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Protect from prolonged exposure to light. Do not freeze.
Lagerung 4 °C
Informationen zur Lagerung The antibody solution should be stored undiluted between 2°C and 8°C.

Referenzen für anti-IRF7 Antikörper (ABIN2662771)

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Owens, Moore, Kaye: "IRF7 regulates TLR2-mediated activation of splenic CD11c(hi) dendritic cells." in: PLoS ONE, Vol. 7, Issue 7, pp. e41050, 2012

Liang, Deng, Sun, Townes, Zhu: "Negative regulation of IRF7 activation by activating transcription factor 4 suggests a cross-regulation between the IFN responses and the cellular integrated stress responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 2, pp. 1001-10, 2011

Buss, Opitz, Hocke, Lippmann, van Laak, Hippenstiel, Krüll, Suttorp, Eitel et al.: "Essential role of mitochondrial antiviral signaling, IFN regulatory factor (IRF)3, and IRF7 in Chlamydophila pneumoniae-mediated IFN-beta response and control of bacterial replication in human ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 184, Issue 6, pp. 3072-8, 2010

Yu, Hayward: "The ubiquitin E3 ligase RAUL negatively regulates type i interferon through ubiquitination of the transcription factors IRF7 and IRF3." in: Immunity, Vol. 33, Issue 6, pp. 863-77, 2010

Balachandran, Venkataraman, Fisher, Barber: "Fas-associated death domain-containing protein-mediated antiviral innate immune signaling involves the regulation of Irf7." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 4, pp. 2429-39, 2007

Joo, Shin, Gack, Wu, Levy, Jung: "Inhibition of interferon regulatory factor 7 (IRF7)-mediated interferon signal transduction by the Kaposi's sarcoma-associated herpesvirus viral IRF homolog vIRF3." in: Journal of virology, Vol. 81, Issue 15, pp. 8282-92, 2007

Bilder

Produktdetails anti-IRF7 Antikörper Target Details IRF7 Anwendungsinformationen Handhabung Referenzen für anti-IRF7 Antikörper (ABIN2662771) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Interferon Regulatory Factor 7 (IRF7) antibody (PE) (ABIN2662771) anti-Interferon Regulatory Factor 7 (IRF7) antibody (PE)