IRF7 Antikörper
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- Target Alle IRF7 Antikörper anzeigen
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser IRF7 Antikörper ist unkonjugiert
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Applikation
- Biochemical Assay (BCA)
- Aufreinigung
- Affinity purified
- Klon
- 12G9A36
- Isotyp
- IgG2b kappa
- Top Product
- Discover our top product IRF7 Primärantikörper
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anti-Interferon Regulatory Factor 7 (IRF7) (pSer471), (pSer472) antibody
IRF7 Reaktivität: Human, Maus, Ratte WB, ELISA, FACS, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 401-503) antibodyIRF7 Reaktivität: Human, Maus, Ratte, Schwein WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 131-289) antibodyIRF7 Reaktivität: Human ELISA, IHC, IF Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 1-150), (N-Term) antibodyIRF7 Reaktivität: Human WB, IHC (p), EIA Wirt: Maus Monoclonal 3D9 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) antibodyIRF7 Reaktivität: Human WB, IF (cc) Wirt: Kaninchen Monoclonal 2A1 unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 257-516) antibodyIRF7 Reaktivität: Human WB Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (C-Term) antibodyIRF7 Reaktivität: Human, Maus, Ratte WB, IHC (p), EIA Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (AA 35-84) antibodyIRF7 Reaktivität: Human, Maus, Ratte, Pferd WB Wirt: Kaninchen Polyclonal unconjugated
anti-Interferon Regulatory Factor 7 (IRF7) (N-Term) antibodyIRF7 Reaktivität: Human, Maus, Ratte, Schwein, Zebrafisch (Danio rerio), Pferd, Rind (Kuh), Kaninchen WB Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
- Optimal working dilution should be determined by the investigator.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Konzentration
- 0.5 mg/mL
- Buffer
- phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C
- Informationen zur Lagerung
- Upon receipt, store undiluted between 2°C and 8°C.
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- Target
- IRF7 (Interferon Regulatory Factor 7 (IRF7))
- Andere Bezeichnung
- IRF7 (IRF7 Produkte)
- Synonyme
- wu:fl24c03 antikoerper, zgc:66043 antikoerper, zgc:77947 antikoerper, IRF7 antikoerper, irf7 antikoerper, IRF-7H antikoerper, IRF7A antikoerper, IRF7B antikoerper, IRF7C antikoerper, IRF7H antikoerper, interferon regulatory factor 7 antikoerper, irf7 antikoerper, IRF7 antikoerper, Irf7 antikoerper
- Hintergrund
- IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection.
- Pathways
- TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, Autophagie
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